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Index > Protein center > FCN2(Gene name) > Human
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  • FCN2 (Gene name),
  • Ficolin-2 (Protein name ),  FCN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FCN2(FCNL);
    Protein name:
    Ficolin-2;
    Alternative:
    Hucolin;Ficolin-beta;Ficolin-B;EBP-37;Serum lectin p35;L-ficolin;37 kDa elastin-binding protein;Collagen/fibrinogen domain-containing protein 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2.
    Function:
    May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    313
    Sequence:
    50:
    MELDRAVGVL | GAATLLLSFL | GMAWALQAAD | TCPEVKMVGL | EGSDKLTILR | 
    100:
    GCPGLPGAPG | PKGEAGTNGK | RGERGPPGPP | GKAGPPGPNG | APGEPQPCLT | 
    150:
    GPRTCKDLLD | RGHFLSGWHT | IYLPDCRPLT | VLCDMDTDGG | GWTVFQRRVD | 
    200:
    GSVDFYRDWA | TYKQGFGSRL | GEFWLGNDNI | HALTAQGTSE | LRVDLVDFED | 
    250:
    NYQFAKYRSF | KVADEAEKYN | LVLGAFVEGS | AGDSLTFHNN | QSFSTKDQDN | 
    300:
    DLNTGNCAVM | FQGAWWYKNC | HVSNLNGRYL | RGTHGSFANG | INWKSGKGYN | 
    313:
    YSYKVSEMKV | RPA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    SMR:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ficolin-2
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    E1907m
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    ELISA Kit for Human Ficolin-2
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    E1907p
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    96T
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    ELISA Kit for Human Ficolin-2
    Cat.:
    E1907h
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    96T
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    ELISA Kit for Human Ficolin-2
    Cat.:
    E1907r
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    Packing:
    96T
    ELISA Kit for Human Ficolin-2
    Cat.:
    E1907b
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    Packing:
    96T
    CLIA Kit for Human Ficolin-2
    Cat.:
    U1907r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ficolin-2
    Cat.:
    U1907m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Ficolin-2
    Cat.:
    U1907p
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    Packing:
    96T
    CLIA Kit for Human Ficolin-2
    Cat.:
    U1907b
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    Packing:
    96T
    CLIA Kit for Human Ficolin-2
    Cat.:
    U1907h
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    Polyclonal Antibody for Human Ficolin-2
    Cat.:
    P1907Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ficolin-2
    Cat.:
    P1907Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ficolin-2
    Polyclonal Antibody for Human Ficolin-2
    Polyclonal Antibody for Human Ficolin-2
    Cat.:
    P1907Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ficolin-2
    Monoclonal Antibody for Human Ficolin-2
    Monoclonal Antibody for Human Ficolin-2
    Monoclonal Antibody for Human Ficolin-2
    Monoclonal Antibody for Human Ficolin-2
    Protein for Human Ficolin-2
    Protein for Human Ficolin-2
    Protein for Human Ficolin-2
    Protein for Human Ficolin-2
    Protein for Human Ficolin-2

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    References
    1. 1.
      "Cloning and characterization of the human lectin P35 gene and its related gene."
      Endo Y. , Sato Y. , Matsushita M. , Fujita T.
      Genomics36:515-521(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin."
      Matsushita M. , Endo Y. , Taira S. , Sato Y. , Fujita T. , Ichikawa N. , Nakata M. , Mizuochi T.
      J. Biol. Chem.271:2448-2454(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      "Genetic variation in immune response genes."
      Tan J. , Ong R. , Hibberd M.L. , Seielstad M.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TYR-113
      tissue: Liver.
    5. 5.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins."
      Edgar P.F.
      FEBS Lett.375:159-161(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-50 (ISOFORM 1)
      tissue: Plasma.
    9. 9.
      "EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, transforming growth factor-beta 1-binding proteins."
      Harumiya S. , Omori A. , Sugiura T. , Fukumoto Y. , Tachikawa H. , Fujimoto D.
      J. Biochem.117:1029-1035(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 65-99; 191-198 AND 218-228 (ISOFORM 1);SUBUNIT;HYDROXYLATION AT PRO-77; PRO-80 AND PRO-86
      tissue: Plasma.
    10. 10.
      "Complement-activating complex of ficolin and mannose-binding lectin-associated serine protease."
      Matsushita M. , Endo Y. , Fujita T.
      J. Immunol.164:2281-2284(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MASP1 AND MASP2
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-80
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