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Index > Protein center > FGF23(Gene name) > Human
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  • FGF23 (Gene name),
  • Fibroblast growth factor 23 (Protein name ),  FGF23_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    FGF23(UNQ3027/PRO9828;HYPF);
    Protein name:
    Fibroblast growth factor 23(FGF-23);
    Alternative:
    Tumor-derived hypophosphatemia-inducing factor;Phosphatonin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors.
    Function:
    Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
    Subcellular Location:
    Secreted Secretion is dependent on O-glycosylation.
    Protein Attributes:
    Sequence length:
    251
    Sequence:
    50:
    MLGARLRLWV | CALCSVCSMS | VLRAYPNASP | LLGSSWGGLI | HLYTATARNS | 
    100:
    YHLQIHKNGH | VDGAPHQTIY | SALMIRSEDA | GFVVITGVMS | RRYLCMDFRG | 
    150:
    NIFGSHYFDP | ENCRFQHQTL | ENGYDVYHSP | QYHFLVSLGR | AKRAFLPGMN | 
    200:
    PPPYSQFLSR | RNEIPLIHFN | TPIPRRHTRS | AEDDSERDPL | NVLKPRARMT | 
    250:
    PAPASCSQEL | PSAEDNSPMA | SDPLGVVRGG | RVNTHAGGTG | PEGCRPFAKF | 
    251:
    I
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    MIM:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human FGF-23
    Cat.:
    E0746m
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    Packing:
    96T
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    ELISA Kit for Human FGF-23
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    E0746h
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    Packing:
    96T
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    ELISA Kit for Human FGF-23
    Cat.:
    E0746r
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    Packing:
    96T
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    CLIA Kit for Human FGF-23
    Cat.:
    U0746h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human FGF-23
    Cat.:
    U0746m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human FGF-23
    Cat.:
    U0746r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human FGF-23
    Cat.:
    P0746Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FGF-23
    Cat.:
    P0746Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FGF-23
    Cat.:
    P0746Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human FGF-23
    Monoclonal Antibody for Human FGF-23
    Monoclonal Antibody for Human FGF-23
    Protein for Human FGF-23
    Protein for Human FGF-23
    Protein for Human FGF-23

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    References
    1. 1.
      "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain."
      Yamashita T. , Yoshioka M. , Itoh N.
      Biochem. Biophys. Res. Commun.277:494-498(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23."
      White K.E. , Evans W.E. , O'Riordan J.L.H. , Speer M.C. , Econs M.J. , Lorenz-Depiereux B. , Grabowski M. , Meitinger T. , Strom T.M.
      Nat. Genet.26:345-348(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;VARIANTS ADHR GLN-176; GLN-179 AND TRP-179;VARIANT MET-239
    3. 3.
      "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia."
      Shimada T. , Mizutani S. , Muto T. , Yoneya T. , Hino R. , Takeda S. , Takeuchi Y. , Fujita T. , Fukumoto S. , Yamashita T.
      Proc. Natl. Acad. Sci. U.S.A.98:6500-6505(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      NIEHS SNPs program
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-195 AND MET-239
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
    8. 8.
      "FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate."
      Bowe A.E. , Finnegan R. , Jan de Beur S.M. , Cho J. , Levine M.A. , Kumar R. , Schiavi S.C.
      Biochem. Biophys. Res. Commun.284:977-981(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CHARACTERIZATION OF VARIANT ADHR GLN-179
    9. 9.
      "The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting."
      White K.E. , Jonsson K.B. , Carn G. , Hampson G. , Spector T.D. , Mannstadt M. , Lorenz-Depiereux B. , Miyauchi A. , Yang I.M. , Ljunggren O. , Meitinger T. , Strom T.M. , Jueppner H. , Econs M.J.
      J. Clin. Endocrinol. Metab.86:497-500(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    10. 10.
      "Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo."
      Shimada T. , Muto T. , Urakawa I. , Yoneya T. , Yamazaki Y. , Okawa K. , Takeuchi Y. , Fujita T. , Fukumoto S. , Yamashita T.
      Endocrinology143:3179-3182(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    11. 11.
      "FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting."
      Riminucci M. , Collins M.T. , Fedarko N.S. , Cherman N. , Corsi A. , White K.E. , Waguespack S. , Gupta A. , Hannon T. , Econs M.J. , Bianco P. , Gehron Robey P.
      J. Clin. Invest.112:683-692(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "FGF23 is processed by proprotein convertases but not by PHEX."
      Benet-Pages A. , Lorenz-Depiereux B. , Zischka H. , White K.E. , Econs M.J. , Strom T.M.
      Bone35:455-462(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY PROPROTEIN CONVERTASES
    13. 13.
      "FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis."
      Shimada T. , Hasegawa H. , Yamazaki Y. , Muto T. , Hino R. , Takeuchi Y. , Fujita T. , Nakahara K. , Fukumoto S. , Yamashita T.
      J. Bone Miner. Res.19:429-435(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X. , Ibrahimi O.A. , Olsen S.K. , Umemori H. , Mohammadi M. , Ornitz D.M.
      J. Biol. Chem.281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4;FUNCTION IN STIMULATION OF CELL PROLIFERATION
    15. 15.
      "Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation."
      Kato K. , Jeanneau C. , Tarp M.A. , Benet-Pages A. , Lorenz-Depiereux B. , Bennett E.P. , Mandel U. , Strom T.M. , Clausen H.
      J. Biol. Chem.281:18370-18377(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION AT THR-178;CHARACTERIZATION OF VARIANTS ADHR GLN-176 AND GLN-179;IDENTIFICATION BY MASS SPECTROMETRY
    16. 16.
      "Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro."
      Wang H. , Yoshiko Y. , Yamamoto R. , Minamizaki T. , Kozai K. , Tanne K. , Aubin J.E. , Maeda N.
      J. Bone Miner. Res.23:939-948(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Fibroblast growth factor signalling: from development to cancer."
      Turner N. , Grose R.
      Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    18. 18.
      "Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members."
      Goetz R. , Beenken A. , Ibrahimi O.A. , Kalinina J. , Olsen S.K. , Eliseenkova A.V. , Xu C. , Neubert T.A. , Zhang F. , Linhardt R.J. , Yu X. , White K.E. , Inagaki T. , Kliewer S.A. , Yamamoto M. , Kurosu H. , Ogawa Y. , Kuro-o M. , more...
      Mol. Cell. Biol.27:3417-3428(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 25-179
    19. 19.
      "A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification."
      Chefetz I. , Heller R. , Galli-Tsinopoulou A. , Richard G. , Wollnik B. , Indelman M. , Koerber F. , Topaz O. , Bergman R. , Sprecher E. , Schoenau E.
      Hum. Genet.118:261-266(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC THR-96
    20. 20.
      "An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia."
      Benet-Pages A. , Orlik P. , Strom T.M. , Lorenz-Depiereux B.
      Hum. Mol. Genet.14:385-390(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC GLY-71
    21. 21.
      "A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis."
      Araya K. , Fukumoto S. , Backenroth R. , Takeuchi Y. , Nakayama K. , Ito N. , Yoshii N. , Yamazaki Y. , Yamashita T. , Silver J. , Igarashi T. , Fujita T.
      J. Clin. Endocrinol. Metab.90:5523-5527(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC PHE-129;CHARACTERIZATION OF VARIANT HFTC PHE-129
    22. 22.
      "A new missense mutation in FGF23 gene in a male with hyperostosis-hyperphosphatemia syndrome (HHS)."
      Abbasi F. , Ghafouri-Fard S. , Javaheri M. , Dideban A. , Ebrahimi A. , Ebrahim-Habibi A.
      Gene542:269-271(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HFTC LEU-157
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