Protein name:
Fibroblast growth factor 23 (FGF-23) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors.
Function:
Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL.
Subcellular Location:
Secreted
Secretion is dependent on O-glycosylation.
Protein Attributes:
50:
MLGACLRLLV | GALCTVCSLG | TARAYSDTSP | LLGSNWGSLT | HLYTATARNS |
100:
YHLQIHRDGH | VDGTPHQTIY | SALMITSEDA | GSVVIIGAMT | RRFLCMDLRG |
150:
NIFGSYHFSP | ENCRFRQWTL | ENGYDVYLSP | KHHYLVSLGR | SKRIFQPGTN |
200:
PPPFSQFLAR | RNEVPLLHFY | TARPRRHTRS | AEDPPERDPL | NVLKPRPRAT |
250:
PIPVSCSREL | PSAEEGGPAA | SDPLGVLRRG | RGDARRGAGG | TDRCRPFPRF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Polyclonal Antibody for Rat FGF-23
Polyclonal Antibody for Rat FGF-23
Polyclonal Antibody for Rat FGF-23
Monoclonal Antibody for Rat FGF-23
Monoclonal Antibody for Rat FGF-23
Monoclonal Antibody for Rat FGF-23
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Rattus norvegicus fgf23."
Itoh N.
Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY