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Index > Protein center > Fgf2(Gene name) > Mouse
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  • Fgf2 (Gene name),
  • Heparin-binding growth factor 2 (Protein name ),  FGF2_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Fgf2(Fgf-2);
    Protein name:
    Heparin-binding growth factor 2(HBGF-2);
    Alternative:
    Heparin-binding growth factor 2(HBGF-2);Basic fibroblast growth factor(bFGF);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2.
    Function:
    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
    Subcellular Location:
    Secreted Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane.
    Protein Attributes:
    Sequence length:
    154
    Sequence:
    50:
    MAASGITSLP | ALPEDGGAAF | PPGHFKDPKR | LYCKNGGFFL | RIHPDGRVDG | 
    100:
    VREKSDPHVK | LQLQAEERGV | VSIKGVCANR | YLAMKEDGRL | LASKCVTEEC | 
    150:
    FFFERLESNN | YNTYRSRKYS | SWYVALKRTG | QYKLGSKTGP | GQKAILFLPM | 
    154:
    SAKS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse HBGF-2
    Cat.:
    E0551b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse HBGF-2
    Cat.:
    E0551h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-2
    Cat.:
    E0551r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-2
    Cat.:
    E0551m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-2
    Cat.:
    E0551c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse HBGF-2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse HBGF-2
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse HBGF-2
    Cat.:
    U0551c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HBGF-2
    Cat.:
    U0551r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse HBGF-2
    Cat.:
    U0551b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HBGF-2
    Cat.:
    U0551h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse HBGF-2
    Cat.:
    U0551m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse HBGF-2
    Cat.:
    P0551Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-2
    Cat.:
    P0551Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-2
    Polyclonal Antibody for Mouse HBGF-2
    Cat.:
    P0551Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse HBGF-2
    Polyclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Monoclonal Antibody for Mouse HBGF-2
    Protein for Mouse HBGF-2
    Protein for Mouse HBGF-2
    Protein for Mouse HBGF-2
    Protein for Mouse HBGF-2
    Protein for Mouse HBGF-2
    Protein for Mouse HBGF-2

    R&D Technical Data
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    s

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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤9.8%

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    Recovery
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    Recovery was determined by spiking various levels of FGF2 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    92-100

    Plasma

    98

    96-107

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of FGF2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-102%

    94-101%

    92-104%

    90-103%

    EDTA plasma(n=5)

    94-103%

    92-102%

    94-102%

    91-107%

    heparin plasma(n=5)

    92-104%

     

    90-107%

    93-104%

    95-102%

     

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    References
    1. 1.
      "Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis."
      Hebert J.M. , Basilico C. , Goldfarb M. , Haub O. , Martin G.R.
      Dev. Biol.138:454-463(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Ma R.Z. , Teuscher C.
      Submitted (1998-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: A/J.
      strain: C57BL/6J.
      strain: NOD/LtJ.
      tissue: Spleen.
    3. 3.
      "Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis."
      Kurtz A. , Wang H.-L. , Darwiche N. , Harris V. , Wellstein A.
      Oncogene14:2671-2681(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF2
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