Protein name:
Fibroblast growth factor 3 (FGF-3) ;
Alternative:
Proto-oncogene Int-2 ;Heparin-binding growth factor 3 (HBGF-3) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Function:
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGLIWLLLLS | LLEPGWPAAG | PGARLRRDAG | GRGGVYEHLG | GAPRRRKLYC |
100:
ATKYHLQLHP | SGRVNGSLEN | SAYSILEITA | VEVGIVAIRG | LFSGRYLAMN |
150:
KRGRLYASEH | YSAECEFVER | IHELGYNTYA | SRLYRTVSST | PGARRQPSAE |
200:
RLWYVSVNGK | GRPRRGFKTR | RTQKSSLFLP | RVLDHRDHEM | VRQLQSGLPR |
239:
PPGKGVQPRR | RRQKQSPDNL | EPSHVQASRL | GSQLEASAH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Human FGF-3
ELISA Kit for Human FGF-3
ELISA Kit for Human FGF-3
Polyclonal Antibody for Human FGF-3
Polyclonal Antibody for Human FGF-3
Polyclonal Antibody for Human FGF-3
Monoclonal Antibody for Human FGF-3
Monoclonal Antibody for Human FGF-3
Monoclonal Antibody for Human FGF-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FGFR1 AND FGFR2;FUNCTION IN CELL PROLIFERATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
5.
"Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia."
Tekin M.
,
Hismi B.O.
,
Fitoz S.
,
Oezdag H.
,
Cengiz F.B.
,
Sirmaci A.
,
Aslan I.
,
Inceoglu B.
,
Yueksel-Konuk E.B.
,
Yilmaz S.T.
,
Yasun O.
,
Akar N.
Am. J. Hum. Genet.80:338-344(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LAMM PRO-156
6.
"Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia."
Tekin M.
,
Ozturkmen Akay H.
,
Fitoz S.
,
Birnbaum S.
,
Cengiz F.B.
,
Sennaroglu L.
,
Incesulu A.
,
Yuksel Konuk E.B.
,
Hasanefendioglu Bayrak A.
,
Senturk S.
,
Cebeci I.
,
Utine G.E.
,
Tuncbilek E.
,
Nance W.E.
,
Duman D.
Clin. Genet.73:554-565(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LAMM PRO-6