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Index > Protein center > FGF3(Gene name) > Human
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  • FGF3 (Gene name),
  • Fibroblast growth factor 3 (Protein name ),  FGF3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FGF3(INT2);
    Protein name:
    Fibroblast growth factor 3(FGF-3);
    Alternative:
    Proto-oncogene Int-2;Heparin-binding growth factor 3(HBGF-3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    Function:
    Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    239
    Sequence:
    50:
    MGLIWLLLLS | LLEPGWPAAG | PGARLRRDAG | GRGGVYEHLG | GAPRRRKLYC | 
    100:
    ATKYHLQLHP | SGRVNGSLEN | SAYSILEITA | VEVGIVAIRG | LFSGRYLAMN | 
    150:
    KRGRLYASEH | YSAECEFVER | IHELGYNTYA | SRLYRTVSST | PGARRQPSAE | 
    200:
    RLWYVSVNGK | GRPRRGFKTR | RTQKSSLFLP | RVLDHRDHEM | VRQLQSGLPR | 
    239:
    PPGKGVQPRR | RRQKQSPDNL | EPSHVQASRL | GSQLEASAH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human FGF-3
    Cat.:
    E15114h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human FGF-3
    MSDS:
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    ELISA Kit for Human FGF-3
    MSDS:
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    CLIA Kit for Human FGF-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human FGF-3
    MSDS:
    Please sign in first.
    CLIA Kit for Human FGF-3
    Cat.:
    U15114h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human FGF-3
    Polyclonal Antibody for Human FGF-3
    Polyclonal Antibody for Human FGF-3
    Monoclonal Antibody for Human FGF-3
    Monoclonal Antibody for Human FGF-3
    Monoclonal Antibody for Human FGF-3
    Protein for Human FGF-3
    Protein for Human FGF-3
    Protein for Human FGF-3

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    Precision
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    Linearity
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    References
    1. 1.
      "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells."
      Brooks S. , Smith R. , Casey G. , Dickson C. , Peters G.
      Oncogene4:429-436(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Receptor specificity of the fibroblast growth factor family."
      Ornitz D.M. , Xu J. , Colvin J.S. , McEwen D.G. , MacArthur C.A. , Coulier F. , Gao G. , Goldfarb M.
      J. Biol. Chem.271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1 AND FGFR2;FUNCTION IN CELL PROLIFERATION
    4. 4.
      "Fibroblast growth factor signalling: from development to cancer."
      Turner N. , Grose R.
      Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    5. 5.
      "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia."
      Tekin M. , Hismi B.O. , Fitoz S. , Oezdag H. , Cengiz F.B. , Sirmaci A. , Aslan I. , Inceoglu B. , Yueksel-Konuk E.B. , Yilmaz S.T. , Yasun O. , Akar N.
      Am. J. Hum. Genet.80:338-344(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAMM PRO-156
    6. 6.
      "Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia."
      Tekin M. , Ozturkmen Akay H. , Fitoz S. , Birnbaum S. , Cengiz F.B. , Sennaroglu L. , Incesulu A. , Yuksel Konuk E.B. , Hasanefendioglu Bayrak A. , Senturk S. , Cebeci I. , Utine G.E. , Tuncbilek E. , Nance W.E. , Duman D.
      Clin. Genet.73:554-565(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LAMM PRO-6
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