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Index > Protein center > FGF4(Gene name) > Human
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  • FGF4 (Gene name),
  • Fibroblast growth factor 4 (Protein name ),  FGF4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FGF4(HST;HSTF1;KS3);
    Protein name:
    Fibroblast growth factor 4(FGF-4);
    Alternative:
    Heparin-binding growth factor 4(HBGF-4);Heparin secretory-transforming protein 1(HST;HST-1;HSTF-1);Transforming protein KS3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    Function:
    Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    206
    Sequence:
    50:
    MSGPGTAAVA | LLPAVLLALL | APWAGRGGAA | APTAPNGTLE | AELERRWESL | 
    100:
    VALSLARLPV | AAQPKEAAVQ | SGAGDYLLGI | KRLRRLYCNV | GIGFHLQALP | 
    150:
    DGRIGGAHAD | TRDSLLELSP | VERGVVSIFG | VASRFFVAMS | SKGKLYGSPF | 
    200:
    FTDECTFKEI | LLPNNYNAYE | SYKYPGMFIA | LSKNGKTKKG | NRVSPTMKVT | 
    206:
    HFLPRL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    UniGene:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human FGF-4
    Cat.:
    E0034h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human FGF-4
    Cat.:
    E0034m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human FGF-4
    Cat.:
    E0034c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human FGF-4
    Cat.:
    E0034b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FGF-4
    Cat.:
    U0034b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FGF-4
    Cat.:
    U0034m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human FGF-4
    Cat.:
    U0034c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human FGF-4
    Cat.:
    U0034h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human FGF-4
    Polyclonal Antibody for Human FGF-4
    Cat.:
    P0034Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human FGF-4
    Polyclonal Antibody for Human FGF-4
    Cat.:
    P0034Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human FGF-4
    Monoclonal Antibody for Human FGF-4
    Monoclonal Antibody for Human FGF-4
    Monoclonal Antibody for Human FGF-4
    Protein for Human FGF-4
    Protein for Human FGF-4
    Protein for Human FGF-4
    Protein for Human FGF-4

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    References
    1. 1.
      "Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal."
      Mayshar Y. , Rom E. , Chumakov I. , Kronman A. , Yayon A. , Benvenisty N.
      Stem Cells26:767-774(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
    2. 2.
      "Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein."
      Yoshida T. , Miyagawa K. , Odagiri H. , Sakamoto H. , Little P.F.R. , Terada M. , Sugimura T.
      Proc. Natl. Acad. Sci. U.S.A.84:7305-7309(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity."
      Taira M. , Yoshida T. , Miyagawa K. , Sakamoto H. , Terada M. , Sugimura T.
      Proc. Natl. Acad. Sci. U.S.A.84:2980-2984(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family."
      Delli-Bovi P. , Curatola A.M. , Kern F.G. , Greco A. , Ittmann M. , Basilico C.
      Cell50:729-737(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Receptor specificity of the fibroblast growth factor family."
      Ornitz D.M. , Xu J. , Colvin J.S. , McEwen D.G. , MacArthur C.A. , Coulier F. , Gao G. , Goldfarb M.
      J. Biol. Chem.271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4;FUNCTION IN CELL PROLIFERATION
    6. 6.
      "Fibroblast growth factor signalling: from development to cancer."
      Turner N. , Grose R.
      Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    7. 7.
      "Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis."
      Bellosta P. , Iwahori A. , Plotnikov A.N. , Eliseenkova A.V. , Basilico C. , Mohammadi M.
      Mol. Cell. Biol.21:5946-5957(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206
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