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Index > Protein center > FGF9(Gene name) > Human
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  • FGF9 (Gene name),
  • Glia-activating factor (Protein name ),  FGF9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FGF9;
    Protein name:
    Glia-activating factor(GAF);
    Alternative:
    Fibroblast growth factor 9(FGF-9);Heparin-binding growth factor 9(HBGF-9);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
    Function:
    Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    208
    Sequence:
    50:
    MAPLGEVGNY | FGVQDAVPFG | NVPVLPVDSP | VLLSDHLGQS | EAGGLPRGPA | 
    100:
    VTDLDHLKGI | LRRRQLYCRT | GFHLEIFPNG | TIQGTRKDHS | RFGILEFISI | 
    150:
    AVGLVSIRGV | DSGLYLGMNE | KGELYGSEKL | TQECVFREQF | EENWYNTYSS | 
    200:
    NLYKHVDTGR | RYYVALNKDG | TPREGTRTKR | HQKFTHFLPR | PVDPDKVPEL | 
    208:
    YKDILSQS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    MIM:
    KEGG:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human GAF
    Cat.:
    E0036h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GAF
    Cat.:
    E0036r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GAF
    Cat.:
    E0036m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GAF
    Cat.:
    E0036p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GAF
    Cat.:
    U0036m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GAF
    Cat.:
    U0036r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GAF
    Cat.:
    U0036h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GAF
    Cat.:
    U0036p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GAF
    Cat.:
    P0036Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GAF
    Polyclonal Antibody for Human GAF
    Cat.:
    P0036Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GAF
    Cat.:
    P0036Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GAF
    Monoclonal Antibody for Human GAF
    Monoclonal Antibody for Human GAF
    Monoclonal Antibody for Human GAF
    Protein for Human GAF
    Protein for Human GAF
    Protein for Human GAF
    Protein for Human GAF

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    References
    1. 1.
      "Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property."
      Miyamoto M. , Naruo K. , Seko C. , Matsumoto S. , Kondo T. , Kurokawa T.
      Mol. Cell. Biol.13:4251-4259(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Foreskin.
    2. 2.
      NIEHS SNPs program
      Submitted (2004-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-94
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    4. 4.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Novel secretory heparin-binding factors from human glioma cells (glia-activating factors) involved in glial cell growth. Purification and biological properties."
      Naruo K. , Seko C. , Kuroshima K. , Matsutani E. , Sasada R. , Kondo T. , Kurokawa T.
      J. Biol. Chem.268:2857-2864(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-26 AND 34-54
      tissue: Glial tumor.
    8. 8.
      "Receptor specificity of the fibroblast growth factor family."
      Ornitz D.M. , Xu J. , Colvin J.S. , McEwen D.G. , MacArthur C.A. , Coulier F. , Gao G. , Goldfarb M.
      J. Biol. Chem.271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR2 AND FGFR3;FUNCTION IN CELL PROLIFERATION
    9. 9.
      "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family."
      Zhang X. , Ibrahimi O.A. , Olsen S.K. , Umemori H. , Mohammadi M. , Ornitz D.M.
      J. Biol. Chem.281:15694-15700(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4;FUNCTION IN STIMULATION OF CELL PROLIFERATION
    10. 10.
      "Fibroblast growth factor signalling: from development to cancer."
      Turner N. , Grose R.
      Nat. Rev. Cancer10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces."
      Hecht H.J. , Adar R. , Hofmann B. , Bogin O. , Weich H. , Yayon A.
      Acta Crystallogr. D57:378-384(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS);SUBUNIT;HEPARIN-BINDING
    12. 12.
      "Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition."
      Plotnikov A.N. , Eliseenkova A.V. , Ibrahimi O.A. , Shriver Z. , Sasisekharan R. , Lemmon M.A. , Mohammadi M.
      J. Biol. Chem.276:4322-4329(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 35-208;SUBUNIT
    13. 13.
      "Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene."
      Wu X.L. , Gu M.M. , Huang L. , Liu X.S. , Zhang H.X. , Ding X.Y. , Xu J.Q. , Cui B. , Wang L. , Lu S.Y. , Chen X.Y. , Zhang H.G. , Huang W. , Yuan W.T. , Yang J.M. , Gu Q. , Fei J. , Chen Z. , more...
      Am. J. Hum. Genet.85:53-63(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SYNS3 ASN-99;CHARACTERIZATION OF VARIANT SYNS3 ASN-99
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