Fgfr1 ELISA Kit for Mouse(Mus musculus) | EIAab.comFgfr1 ELISA Kit for Mouse(Mus musculus)

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Fgfr1 (Gene name),

Fibroblast growth factor receptor 1 (Protein name ), FGFR1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fgfr1(Flg);

Protein name:

Fibroblast growth factor receptor 1(FGFR-1;bFGF-R-1);

Alternative:

MFR;Basic fibroblast growth factor receptor 1;Proto-oncogene c-Fgr;

CD:

CD331;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF5, FGF6, FGF8, FGF10, FGF19, FGF21, FGF22 and FGF23 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19, FGF21 and FGF23. Interacts (phosphorylated on Tyr-766) with PLCG1 (via SH2 domains). Interacts with FRS2A. Interacts (via C-terminus) with NEDD4 (via WW3 domain). Interacts with KL (By similarity). Interacts with SHB (via SH2 domain) and GRB10. Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2 (By similarity). Interacts with SOX2 and SOX3.

Function:

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2A, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2A triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Subcellular Location:

Isoform 5 Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

822

Sequence:

50:

100:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

822:

LPEEPCLPRH | PTQLANSGLK | RR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P16092

KEGG:

mmu:14182

Pfam:

PF07679

UniGene:

Mm.265716

SMR:

P16092

Uniprot:

P16092

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ELISA Kit for Mouse FGFR-1

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E0074m

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96T

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ELISA Kit for Mouse FGFR-1

Cat.:

E0074h

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96T

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ELISA Kit for Mouse FGFR-1

Cat.:

E0074r

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96T

ELISA Kit for Mouse FGFR-1

Cat.:

E0074c

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96T

CLIA Kit for Mouse FGFR-1

Cat.:

U0074h

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96T

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CLIA Kit for Mouse FGFR-1

Cat.:

U0074r

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96T

CLIA Kit for Mouse FGFR-1

Cat.:

U0074c

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96T

CLIA Kit for Mouse FGFR-1

Cat.:

U0074m

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96T

Polyclonal Antibody for Mouse FGFR-1

Cat.:

P0074Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse FGFR-1

Cat.:

P0074Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse FGFR-1

Cat.:

P0074Rb-m

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Monoclonal Antibody for Mouse FGFR-1

Protein for Mouse FGFR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain."
Reid H.H. , Wilks A.F. , Bernard O.
Proc. Natl. Acad. Sci. U.S.A.87:1596-1600(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"The murine flg gene encodes a receptor for fibroblast growth factor."
Safran A. , Avivi A. , Orr-Urtereger A. , Neufeld G. , Lonai P. , Givol D. , Yarden Y.
Oncogene5:635-643(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6)
strain: BALB/c.
tissue: Brain.
3.

"Expression cDNA cloning of fibroblast growth factor (FGF) receptor in mouse breast cancer cells: a variant form in FGF-responsive transformed cells."
Kouhara H. , Kasayama S. , Saito H. , Matsumoto K. , Sato B.
Biochem. Biophys. Res. Commun.176:31-37(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING
4.

"A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF."
Mansukhani A. , Moscatelli D. , Talarico D. , Levytska V. , Basilico C.
Proc. Natl. Acad. Sci. U.S.A.87:4378-4382(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.

"Cloning and expression of fibroblast growth factor receptor-1 isoforms in the mouse heart: evidence for isoform switching during heart development."
Jin Y. , Pasumarthi K.B. , Bock M.E. , Lytras A. , Kardami E. , Cattini P.A.
J. Mol. Cell. Cardiol.26:1449-1459(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
strain: Swiss Webster.
tissue: Embryonic heart.
6.

"Fibroblast growth factor (FGF) receptor 1-IIIb is a naturally occurring functional receptor for FGFs that is preferentially expressed in the skin and the brain."
Beer H.-D. , Vindevoghel L. , Gait M.J. , Revest J.-M. , Duan D.R. , Mason I. , Dickson C. , Werner S.
J. Biol. Chem.275:16091-16097(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);SUBCELLULAR LOCATION;FUNCTION AS FGF7 RECEPTOR AND IN ACTIVATION OF SIGNALING PATHWAYS;INTERACTION WITH FGF1; FGF2; FGF7 AND FGF10;GLYCOSYLATION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING
strain: BALB/c.
7.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Placenta.
8.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain: FVB/N.
tissue: Mammary tumor.
10.

"Murine fibroblast growth factor receptor 1 gene generates multiple messenger RNAs containing two open reading frames via alternative splicing."
Harada T. , Saito H. , Kouhara H. , Kurebayashi S. , Kasayama S. , Terakawa N. , Kishimoto T. , Sato B.
Biochem. Biophys. Res. Commun.205:1057-1063(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-15;ALTERNATIVE SPLICING
11.

"Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells."
Ornitz D.M. , Yayon A. , Flanagan J.G. , Svahn C.M. , Levi E. , Leder P.
Mol. Cell. Biol.12:240-247(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FGF1; FGF2; FGF4; FGF5; FGF6;FUNCTION IN CELL PROLIFERATION
12.

"fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation."
Yamaguchi T.P. , Harpal K. , Henkemeyer M. , Rossant J.
Genes Dev.8:3032-3044(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION DURING EMBRYONIC DEVELOPMENT
13.

"Murine FGFR-1 is required for early postimplantation growth and axial organization."
Deng C.X. , Wynshaw-Boris A. , Shen M.M. , Daugherty C. , Ornitz D.M. , Leder P.
Genes Dev.8:3045-3057(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION DURING EMBRYONIC DEVELOPMENT
14.

"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M. , Xu J. , Colvin J.S. , McEwen D.G. , MacArthur C.A. , Coulier F. , Gao G. , Goldfarb M.
J. Biol. Chem.271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;LIGAND SPECIFICITY
15.

"Fibroblast growth factor (FGF)-2 directly stimulates mature osteoclast function through activation of FGF receptor 1 and p42/p44 MAP kinase."
Chikazu D. , Hakeda Y. , Ogata N. , Nemoto K. , Itabashi A. , Takato T. , Kumegawa M. , Nakamura K. , Kawaguchi H.
J. Biol. Chem.275:31444-31450(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
16.

"The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells."
Cross M.J. , Lu L. , Magnusson P. , Nyqvist D. , Holmqvist K. , Welsh M. , Claesson-Welsh L.
Mol. Biol. Cell13:2881-2893(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
17.

"Ligand dependent and independent internalization and nuclear translocation of fibroblast growth factor (FGF) receptor 1."
Reilly J.F. , Mizukoshi E. , Maher P.A.
DNA Cell Biol.23:538-548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
18.

"Klotho converts canonical FGF receptor into a specific receptor for FGF23."
Urakawa I. , Yamazaki Y. , Shimada T. , Iijima K. , Hasegawa H. , Okawa K. , Fujita T. , Fukumoto S. , Yamashita T.
Nature444:770-774(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KL AND FGF23
19.

"SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis."
Rizzoti K. , Lovell-Badge R.
Development134:3437-3448(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOX2 AND SOX3
20.

"BetaKlotho is required for metabolic activity of fibroblast growth factor 21."
Ogawa Y. , Kurosu H. , Yamamoto M. , Nandi A. , Rosenblatt K.P. , Goetz R. , Eliseenkova A.V. , Mohammadi M. , Kuro-o M.
Proc. Natl. Acad. Sci. U.S.A.104:7432-7437(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLB
21.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-317
22.

"NMR structure of the first Ig module of mouse FGFR1."
Kiselyov V.V. , Bock E. , Berezin V. , Poulsen F.M.
Protein Sci.15:1512-1515(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 25-119

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