FGB ELISA Kit for Human(Homo sapiens) | EIAab.comFGB ELISA Kit for Human(Homo sapiens)

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FGB (Gene name),

Fibrinogen beta chain (Protein name ), FIBB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FGB;

Protein name:

Fibrinogen beta chain;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

Function:

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

491

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

491:

QYTWDMAKHG | TDDGVVWMNW | KGSWYSMRKM | SMKIRPFFPQ | Q

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P02675

UniGene:

Hs.300774

Pfam:

PF08702

SMR:

P02675

MIM:

134830

KEGG:

hsa:2244

STRING:

9606.ENSP00000306099

Uniprot:

P02675

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ELISA Kit for Human Fibrinogen beta chain

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E1307h

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96T

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ELISA Kit for Human Fibrinogen beta chain

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E1307r

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96T

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ELISA Kit for Human Fibrinogen beta chain

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E1307m

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96T

ELISA Kit for Human Fibrinogen beta chain

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ELISA Kit for Human Fibrinogen beta chain

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E1307d

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ELISA Kit for Human Fibrinogen beta chain

Cat.:

E1307c

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96T

ELISA Kit for Human Fibrinogen beta chain

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E1307b

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96T

ELISA Kit for Human Fibrinogen beta chain

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CLIA Kit for Human Fibrinogen beta chain

Cat.:

U1307m

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96T

CLIA Kit for Human Fibrinogen beta chain

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U1307c

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96T

CLIA Kit for Human Fibrinogen beta chain

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U1307b

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96T

CLIA Kit for Human Fibrinogen beta chain

Cat.:

U1307r

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96T

CLIA Kit for Human Fibrinogen beta chain

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CLIA Kit for Human Fibrinogen beta chain

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CLIA Kit for Human Fibrinogen beta chain

MSDS:

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CLIA Kit for Human Fibrinogen beta chain

Cat.:

U1307h

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96T

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Polyclonal Antibody for Human Fibrinogen beta chain

Cat.:

P1307Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Fibrinogen beta chain

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P1307Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Fibrinogen beta chain

Cat.:

P1307Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Fibrinogen beta chain

Monoclonal Antibody for Human Fibrinogen beta chain

Protein for Human Fibrinogen beta chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen."
Chung D.W. , Que B.G. , Rixon M.W. , Mace M. Jr. , Davie E.W.
Biochemistry22:3244-3250(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
2.

"Nucleotide sequences of the three genes coding for human fibrinogen."
Chung D.W. , Harris J.E. , Davie E.W.
Adv. Exp. Med. Biol.281:39-48(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Nucleotide sequences of the three genes coding for human fibrinogen."
Chung D.W. , Harris J.E. , Davie E.W.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

SeattleSNPs variation discovery resource
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-100; HIS-170; LEU-265 AND LYS-478
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Mammary gland.
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Liver.
8.

"Cloning of fibrinogen genes and their cDNA."
Chung D.W. , Rixon M.W. , Que B.G. , Davie E.W.
Ann. N. Y. Acad. Sci.408:449-456(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60
9.

"Characterization of the 5'-flanking region for the human fibrinogen beta gene."
Huber P. , Dalmon J. , Courtois G. , Laurent M. , Assouline Z. , Marguerie G.
Nucleic Acids Res.15:1615-1625(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38
10.

"Amino acid sequence of the beta chain of human fibrinogen."
Watt K.W.K. , Takagi T. , Doolittle R.F.
Biochemistry18:68-76(1979) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-491;PYROGLUTAMATE FORMATION AT GLN-31
11.

"Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants."
Henschen A. , Lottspeich F. , Southan C. , Topfer-Petersen E.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-491;GLYCOSYLATION AT ASN-394
12.

"Disulfide bridges in NH2-terminal part of human fibrinogen."
Blombaeck B. , Hessel B. , Hogg D.
Thromb. Res.8:639-658(1976) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-148;DISULFIDE BONDS
13.

"Studies on fibrinopeptides from primates."
Blombaeck B. , Blombaeck M. , Grondahl N.J. , Guthrie C. , Hinton M.
Acta Chem. Scand.19:1788-1789(1965)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-44
14.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-53
tissue: Platelet.
15.

Lubec G. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 54-72; 164-178 AND 225-239;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Fetal brain cortex.
16.

"Covalent structure of fibrinogen."
Henschen A. , Lottspeich F. , Kehl M. , Southan C.
Ann. N. Y. Acad. Sci.408:28-43(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;DISULFIDE BONDS
17.

"Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments."
Gaardlund B. , Hessel B. , Marguerie G. , Murano G. , Blombaeck B.
Eur. J. Biochem.77:595-610(1977) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
18.

"The structures of fibrinogen and fibrin."
Doolittle R.F. , Takagi T. , Watt K.W.K. , Bouma H. III , Cottrell B.A. , Cassman K.G. , Goldbaum D.M. , Doolittle L.R. , Friezner S.J.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
19.

"Fibrinogen and fibrin."
Doolittle R.F.
Annu. Rev. Biochem.53:195-229(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;ELECTRON MICROSCOPY;POLYMERIZATION;LIGANDS
20.

"The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis."
Tran H. , Tanaka A. , Litvinovich S.V. , Medved L.V. , Haudenschild C.C. , Argraves W.S.
J. Biol. Chem.270:19458-19464(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN1
21.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
tissue: Plasma.
22.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
tissue: Platelet.
23.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
tissue: Liver.
24.

"A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule."
Kirschbaum N.E. , Budzynski A.Z.
J. Biol. Chem.265:13669-13676(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY HEMENTIN AND PLASMIN
25.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.

"Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin."
Spraggon G. , Everse S.J. , Doolittle R.F.
Nature389:455-462(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 164-491
27.

"Crystal structure of fragment double-D from human fibrin with two different bound ligands."
Everse S.J. , Spraggon G. , Veerapandian L. , Riley M. , Doolittle R.F.
Biochemistry37:8637-8642(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 164-491
28.

"Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."
Everse S.J. , Spraggon G. , Veerapandian L. , Doolittle R.F.
Biochemistry38:2941-2946(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 164-491
29.

"A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II."
Schmelzer C.H. , Ebert R.F. , Bell W.R.
Thromb. Res.52:173-177(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BALTIMORE-2 LYS-478
30.

"A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine."
Yoshida N. , Wada H. , Morita K. , Hirata H. , Matsuda M. , Yamazumi K. , Asakura S. , Shirakawa S.
Blood77:1958-1963(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ISE ARG-45
31.

"Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr."
Koopman J. , Haverkate F. , Lord S.T. , Grimbergen J. , Mannucci P.M.
J. Clin. Invest.90:238-244(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NAPLES THR-98
32.

"Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes."
Koopman J. , Haverkate F. , Grimbergen J. , Engesser L. , Novakova I. , Kerst A.F.J.A. , Lord S.T.
Proc. Natl. Acad. Sci. U.S.A.89:3478-3482(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IJMUIDEN CYS-44 AND NIJMEGEN CYS-74
33.

"Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene."
Liu C.Y. , Koehn J.A. , Morgan F.J.
J. Biol. Chem.260:4390-4396(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEW YORK-1 39-GLY--LEU-102 DEL
34.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-2; LEU-265 AND LYS-478
35.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
36.

"Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion."
Duga S. , Asselta R. , Santagostino E. , Zeinali S. , Simonic T. , Malcovati M. , Mannucci P.M. , Tenchini M.L.
Blood95:1336-1341(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CONGENITAL AFIBRINOGENEMIA ARG-383 AND ASP-430
37.

"The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers."
Lounes K.C. , Lefkowitz J.B. , Henschen-Edman A.H. , Coates A.I. , Hantgan R.R. , Lord S.T.
Blood98:661-666(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CONGENITAL AFIBRINOGENEMIA CYS-196

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