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Index > Protein center > FGB(Gene name) > Human
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  • FGB (Gene name),
  • Fibrinogen beta chain (Protein name ),  FIBB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    FGB;
    Protein name:
    Fibrinogen beta chain;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    Function:
    Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    491
    Sequence:
    50:
    MKRMVSWSFH | KLKTMKHLLL | LLLCVFLVKS | QGVNDNEEGF | FSARGHRPLD | 
    100:
    KKREEAPSLR | PAPPPISGGG | YRARPAKAAA | TQKKVERKAP | DAGGCLHADP | 
    150:
    DLGVLCPTGC | QLQEALLQQE | RPIRNSVDEL | NNNVEAVSQT | SSSSFQYMYL | 
    200:
    LKDLWQKRQK | QVKDNENVVN | EYSSELEKHQ | LYIDETVNSN | IPTNLRVLRS | 
    250:
    ILENLRSKIQ | KLESDVSAQM | EYCRTPCTVS | CNIPVVSGKE | CEEIIRKGGE | 
    300:
    TSEMYLIQPD | SSVKPYRVYC | DMNTENGGWT | VIQNRQDGSV | DFGRKWDPYK | 
    350:
    QGFGNVATNT | DGKNYCGLPG | EYWLGNDKIS | QLTRMGPTEL | LIEMEDWKGD | 
    400:
    KVKAHYGGFT | VQNEANKYQI | SVNKYRGTAG | NALMDGASQL | MGENRTMTIH | 
    450:
    NGMFFSTYDR | DNDGWLTSDP | RKQCSKEDGG | GWWYNRCHAA | NPNGRYYWGG | 
    491:
    QYTWDMAKHG | TDDGVVWMNW | KGSWYSMRKM | SMKIRPFFPQ | Q
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    SMR:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Fibrinogen beta chain
    MSDS:
    Please sign in first.
    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Fibrinogen beta chain
    Cat.:
    E1307b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Fibrinogen beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Fibrinogen beta chain
    Cat.:
    U1307m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen beta chain
    Cat.:
    U1307c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen beta chain
    Cat.:
    U1307b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen beta chain
    Cat.:
    U1307r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Fibrinogen beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Fibrinogen beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Fibrinogen beta chain
    Cat.:
    U1307h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Fibrinogen beta chain
    Polyclonal Antibody for Human Fibrinogen beta chain
    Cat.:
    P1307Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fibrinogen beta chain
    Polyclonal Antibody for Human Fibrinogen beta chain
    Polyclonal Antibody for Human Fibrinogen beta chain
    Polyclonal Antibody for Human Fibrinogen beta chain
    Cat.:
    P1307Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fibrinogen beta chain
    Cat.:
    P1307Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Monoclonal Antibody for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain
    Protein for Human Fibrinogen beta chain

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen."
      Chung D.W. , Que B.G. , Rixon M.W. , Mace M. Jr. , Davie E.W.
      Biochemistry22:3244-3250(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "Nucleotide sequences of the three genes coding for human fibrinogen."
      Chung D.W. , Harris J.E. , Davie E.W.
      Adv. Exp. Med. Biol.281:39-48(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Nucleotide sequences of the three genes coding for human fibrinogen."
      Chung D.W. , Harris J.E. , Davie E.W.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-100; HIS-170; LEU-265 AND LYS-478
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Mammary gland.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60
    9. 9.
      "Characterization of the 5'-flanking region for the human fibrinogen beta gene."
      Huber P. , Dalmon J. , Courtois G. , Laurent M. , Assouline Z. , Marguerie G.
      Nucleic Acids Res.15:1615-1625(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38
    10. 10.
      "Amino acid sequence of the beta chain of human fibrinogen."
      Watt K.W.K. , Takagi T. , Doolittle R.F.
      Biochemistry18:68-76(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-491;PYROGLUTAMATE FORMATION AT GLN-31
    11. 11.
      "Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants."
      Henschen A. , Lottspeich F. , Southan C. , Topfer-Petersen E.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-491;GLYCOSYLATION AT ASN-394
    12. 12.
      "Disulfide bridges in NH2-terminal part of human fibrinogen."
      Blombaeck B. , Hessel B. , Hogg D.
      Thromb. Res.8:639-658(1976) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-148;DISULFIDE BONDS
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-44
    14. 14.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-53
      tissue: Platelet.
    15. 15.
      Lubec G. , Chen W.-Q. , Sun Y.
      Submitted (2008-12) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 54-72; 164-178 AND 225-239;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Fetal brain cortex.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;DISULFIDE BONDS
    17. 17.
      "Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments."
      Gaardlund B. , Hessel B. , Marguerie G. , Murano G. , Blombaeck B.
      Eur. J. Biochem.77:595-610(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;ELECTRON MICROSCOPY;POLYMERIZATION;LIGANDS
    20. 20.
      "The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis."
      Tran H. , Tanaka A. , Litvinovich S.V. , Medved L.V. , Haudenschild C.C. , Argraves W.S.
      J. Biol. Chem.270:19458-19464(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN1
    21. 21.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
      tissue: Plasma.
    22. 22.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
      tissue: Platelet.
    23. 23.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-394
      tissue: Liver.
    24. 24.
      "A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule."
      Kirschbaum N.E. , Budzynski A.Z.
      J. Biol. Chem.265:13669-13676(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY HEMENTIN AND PLASMIN
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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      "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin."
      Spraggon G. , Everse S.J. , Doolittle R.F.
      Nature389:455-462(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 164-491
    27. 27.
      "Crystal structure of fragment double-D from human fibrin with two different bound ligands."
      Everse S.J. , Spraggon G. , Veerapandian L. , Riley M. , Doolittle R.F.
      Biochemistry37:8637-8642(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 164-491
    28. 28.
      "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."
      Everse S.J. , Spraggon G. , Veerapandian L. , Doolittle R.F.
      Biochemistry38:2941-2946(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 164-491
    29. 29.
      "A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II."
      Schmelzer C.H. , Ebert R.F. , Bell W.R.
      Thromb. Res.52:173-177(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BALTIMORE-2 LYS-478
    30. 30.
      "A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine."
      Yoshida N. , Wada H. , Morita K. , Hirata H. , Matsuda M. , Yamazumi K. , Asakura S. , Shirakawa S.
      Blood77:1958-1963(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ISE ARG-45
    31. 31.
      "Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr."
      Koopman J. , Haverkate F. , Lord S.T. , Grimbergen J. , Mannucci P.M.
      J. Clin. Invest.90:238-244(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NAPLES THR-98
    32. 32.
      "Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes."
      Koopman J. , Haverkate F. , Grimbergen J. , Engesser L. , Novakova I. , Kerst A.F.J.A. , Lord S.T.
      Proc. Natl. Acad. Sci. U.S.A.89:3478-3482(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IJMUIDEN CYS-44 AND NIJMEGEN CYS-74
    33. 33.
      "Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene."
      Liu C.Y. , Koehn J.A. , Morgan F.J.
      J. Biol. Chem.260:4390-4396(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEW YORK-1 39-GLY--LEU-102 DEL
    34. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-2; LEU-265 AND LYS-478
    35. 35.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    36. 36.
      "Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion."
      Duga S. , Asselta R. , Santagostino E. , Zeinali S. , Simonic T. , Malcovati M. , Mannucci P.M. , Tenchini M.L.
      Blood95:1336-1341(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CONGENITAL AFIBRINOGENEMIA ARG-383 AND ASP-430
    37. 37.
      "The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers."
      Lounes K.C. , Lefkowitz J.B. , Henschen-Edman A.H. , Coates A.I. , Hantgan R.R. , Lord S.T.
      Blood98:661-666(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CONGENITAL AFIBRINOGENEMIA CYS-196
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