Protein name:
Fibronectin (FN) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, FBLN7, AMBP, LGALS3BP, COL13A1 and COMP (By similarity). Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth. Interacts with FST3.
Function:
Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MLRGPGPGRL | LLLAVLCLGT | SVRCTETGKS | KRQAQQIVQP | PSPVAVSQSK |
100:
PGCFDNGKHY | QINQQWERTY | LGNALVCTCY | GGSRGFNCES | KPEPEETCFD |
150:
KYTGNTYKVG | DTYERPKDSM | IWDCTCIGAG | RGRISCTIAN | RCHEGGQSYK |
200:
IGDKWRRPHE | TGGYMLECLC | LGNGKGEWTC | KPIAEKCFDH | AAGTSYVVGE |
250:
TWEKPYQGWM | MVDCTCLGEG | NGRITCTSRN | RCNDQDTRTS | YRIGDTWSKK |
300:
DNRGNLLQCV | CTGNGRGEWK | CERHVLQSAS | AGSGSFTDVR | TAIYQPQTHP |
350:
QPAPYGHCVT | DSGVVYSVGM | QWLKSQGDKQ | MLCTCLGNGV | SCQETAVTQT |
400:
YGGNSNGEPC | VLPFHYNGRT | FYSCTTEGRQ | DGHLWCSTTS | NYEQDQKYSF |
450:
CTDHAVLVQT | RGGNSNGALC | HFPFLYSNRN | YSDCTSEGRR | DNMKWCGTTQ |
500:
NYDADQKFGF | CPMAAHEEIC | TTNEGVMYRI | GDQWDKQHDL | GHMMRCTCVG |
550:
NGRGQWACIP | YSQLRDQCIV | DDITYNVNDT | FHKRHEEGHM | LNCTCFGQGR |
600:
GRWKCDPIDR | CQDSETRTFY | QIGDSWEKFV | HGVRYQCYCY | GRGIGEWHCQ |
650:
PLQTYPGTTG | PVQVIITETP | SQPNSHPIQW | NAPEPSHITK | YILRWRPKTS |
700:
TGRWKEATIP | GHLNSYTIKG | LTPGVIYEGQ | LISIQQYGHQ | EVTRFDFTTS |
750:
ASTPVTSNTV | TGETAPFSPV | VATSESVTEI | TASSFVVSWV | SASDTVSGFR |
800:
VEYELSEEGD | EPQYLDLPST | ATSVNIPDLL | PGRKYIVNVY | QISEEGKQSL |
850:
ILSTSQTTAP | DAPPDPTVDQ | VDDTSIVVRW | SRPQAPITGY | RIVYSPSVEG |
900:
SSTELNLPET | ANSVTLSDLQ | PGVQYNITIY | AVEENQESTP | VFIQQETTGV |
950:
PRSDDVPAPK | DLQFVEVTDV | KVTIMWTPPN | SAVTGYRVDV | LPVNLPGEHG |
1000:
QRLPVNRNTF | AEVTGLSPGV | TYLFKVFAVH | QGRESKPLTA | QQTTKLDAPT |
1050:
NLQFVNETDR | TVLVTWTPPR | ARIAGYRLTV | GLTRGGQPKQ | YNVGPMASKY |
1100:
PLRNLQPGSE | YTVTLMAVKG | NQQSPKATGV | FTTLQPLRSI | PPYNTEVTET |
1150:
TIVITWTPAP | RIGFKLGVRP | SQGGEAPREV | TSDSGSIVVS | GLTPGVEYTY |
1200:
TIQVLRDGQE | RDAPIVNRVV | TPLSPPTNLH | LEANPDTGVL | TVSWERSTTP |
1250:
DITGYRITTT | PTNGQQGTAL | EEVVHADQSS | CTFENRNPGL | EYNVSVYTVK |
1300:
DDKESAPISD | TVIPEVPQLT | DLSFVDITDS | SIGLRWTPLN | SSTIIGYRIT |
1350:
VVAAGEGIPI | FEDFVDSSVG | YYTVTGLEPG | IDYDISVITL | INGGESAPTT |
1400:
LTQQTAVPPP | TDLRFTNIGP | DTMRVTWAPP | PSIELTNLLV | RYSPVKNEED |
1450:
VAELSISPSD | NAVVLTNLLP | GTEYLVSVSS | VYEQHESIPL | RGRQKTGLDS |
1500:
PTGFDSSDVT | ANSFTVHWVA | PRAPITGYII | RHHAEHSAGR | PRQDRVPPSR |
1550:
NSITLTNLNP | GTEYIVTIIA | VNGREESPPL | IGQQSTVSDV | PRDLEVIAST |
1600:
PTSLLISWEP | PAVSVRYYRI | TYGETGGNSP | VQEFTVPGSK | STATINNIKP |
1650:
GADYTITLYA | VTGRGDSPAS | SKPVSINYQT | EIDKPSQMQV | TDVQDNSISV |
1700:
RWLPSTSPVT | GYRVTTAPKN | GLGPTKSQTV | SPDQTEMTIE | GLQPTVEYVV |
1750:
SVYAQNRNGE | SQPLVQTAVT | NIDRPKGLAF | TDVDVDSIKI | AWESPQGQVS |
1800:
RYRVTYSSPE | DGIHELFPAP | DGDEDTAELH | GLRPGSEYTV | SVVALHGGME |
1850:
SQPLIGVQST | AIPAPTNLKF | TQVSPTTLTA | QWTAPSVKLT | GYRVRVTPKE |
1900:
KTGPMKEINL | SPDSTSVIVS | GLMVATKYEV | SVYALKDTLT | SRPAQGVVTT |
1950:
LENVSPPRRA | RVTDATETTI | TISWRTKTET | ITGFQVDAIP | ANGQTPVQRT |
2000:
ISPDVRSYTI | TGLQPGTDYK | IHLYTLNDNA | RSSPVVIDAS | TAIDAPSNLR |
2050:
FLTTTPNSLL | VSWQAPRARI | TGYIIKYEKP | GSPPREVVPR | PRPGVTEATI |
2100:
TGLEPGTEYT | IYVIALKNNQ | KSEPLIGRKK | TDELPQLVTL | PHPNLHGPEI |
2150:
LDVPSTVQKT | PFVTNPGYDT | ENGIQLPGTS | HQQPSVGQQM | IFEEHGFRRT |
2200:
TPPTAATPVR | LRPRPYLPNV | DEEVQIGHVP | RGDVDYHLYP | HVPGLNPNAS |
2250:
TGQEALSQTT | ISWTPFQESS | EYIISCQPVG | TDEEPLQFQV | PGTSTSATLT |
2300:
GLTRGVTYNI | IVEALHNQRR | HKVREEVVTV | GNTVNEGLNQ | PTDDSCFDPY |
2350:
TVSHYAVGEE | WERLSDSGFK | LTCQCLGFGS | GHFRCDSSKW | CHDNGVNYKI |
2400:
GEKWDRQGEN | GQRMSCTCLG | NGKGEFKCDP | HEATCYDDGK | TYHVGEQWQK |
2450:
EYLGAICSCT | CFGGQRGWRC | DNCRRPGAAE | PSPDGTTGHT | YNQYTQRYHQ |
2477:
RTNTNVNCPI | ECFMPLDVQA | DRDDSRE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Dog
Bovine
Chicken
Rabbit
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Polyclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
Monoclonal Antibody for Rat FN
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Fischer .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-139 AND 2382-2477
strain :
Fischer .
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1586-2477
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1722-1810;ALTERNATIVE SPLICING
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2052-2237;ALTERNATIVE SPLICING
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1183-1192; 1385-1399 AND 2287-2300;INTERACTION WITH AMBP