FKBP8 ELISA Kit for Human(Homo sapiens) | EIAab.comFKBP8 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FKBP8(Gene name) > Human

FKBP8 (Gene name),

Peptidyl-prolyl cis-trans isomerase FKBP8 (Protein name ), FKBP8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FKBP8(FKBP38);

Protein name:

Peptidyl-prolyl cis-trans isomerase FKBP8(PPIase FKBP8);

Alternative:

FK506-binding protein 8(FKBP-8);38 kDa FK506-binding protein(38 kDa FKBP;FKBP-38;hFKBP38);Rotamase;FKBPR38;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.

Function:

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Subcellular Location:

Mitochondrion membrane Single-pass membrane protein Cytoplasmic side

Protein Attributes:

Sequence length:

412

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

412:

GVALSVVIAA | RN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q14318

STRING:

9606.ENSP00000222308

Pfam:

PF00254

UniGene:

Hs.173464

SMR:

Q14318

KEGG:

hsa:23770

MIM:

604840

Uniprot:

Q14318

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ELISA Kit for Human PPIase FKBP8

Cat.:

E11198h

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96T

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ELISA Kit for Human PPIase FKBP8

Cat.:

E11198m

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Packing:

96T

ELISA Kit for Human PPIase FKBP8

Cat.:

E11198r

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Packing:

96T

CLIA Kit for Human PPIase FKBP8

Cat.:

U11198h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human PPIase FKBP8

Cat.:

U11198m

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MSDS:

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Packing:

96T

CLIA Kit for Human PPIase FKBP8

Cat.:

U11198r

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96T

Polyclonal Antibody for Human PPIase FKBP8

Cat.:

P11198Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PPIase FKBP8

Monoclonal Antibody for Human PPIase FKBP8

Protein for Human PPIase FKBP8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis."
Shirane M. , Nakayama K.I.
Nat. Cell Biol.5:28-37(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH BCL2 AND BCL2L1/BCLXL;SUBCELLULAR LOCATION
2.

"FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."
Bulgakov O.V. , Eggenschwiler J.T. , Hong D.-H. , Anderson K.V. , Li T.
Development131:2149-2159(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells."
Chen Y. , Sternberg P. , Cai J.
Invest. Ophthalmol. Vis. Sci.49:1721-1727(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);SUBCELLULAR LOCATION;INTERACTION WITH BCL2L1;TISSUE SPECIFICITY
tissue: Retinal pigment epithelium.
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Colon endothelium.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs."
Lam E. , Martin M. , Wiederrecht G.
Gene160:297-302(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-412 (ISOFORM 1)
8.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-412 (ISOFORM 2)
tissue: Liver.
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-412 (ISOFORM 1)
tissue: Pancreas.
10.

"Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2."
Kang C.B. , Feng L. , Chia J. , Yoon H.S.
Biochem. Biophys. Res. Commun.337:30-38(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin."
Edlich F. , Weiwad M. , Erdmann F. , Fanghaenel J. , Jarczowski F. , Rahfeld J.-U. , Fischer G.
EMBO J.24:2688-2699(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;COFACTOR
12.

"A reassessment of the inhibitory capacity of human FKBP38 on calcineurin."
Weiwad M. , Edlich F. , Erdmann F. , Jarczowski F. , Kilka S. , Dorn M. , Pechstein A. , Fischer G.
FEBS Lett.579:1591-1596(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ABSENCE OF DIRECT INTERACTION WITH CALCINEURIN
13.

"The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."
Kang C.B. , Tai J. , Chia J. , Yoon H.S.
FEBS Lett.579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2
14.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."
Portier B.P. , Taglialatela G.
J. Biol. Chem.281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL2
16.

"Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells."
Wang J. , Tong W. , Zhang X. , Chen L. , Yi Z. , Pan T. , Hu Y. , Xiang L. , Yuan Z.
FEBS Lett.580:4392-4400(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV NS5A
17.

"Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."
Shirane M. , Ogawa M. , Motoyama J. , Nakayama K.I.
Genes Cells13:635-651(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZFYVE27
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Solution structure of the FK506-binding domain of human FKBP38."
Maestre-Martinez M. , Edlich F. , Jarczowski F. , Weiwad M. , Fischer G. , Luecke C.
J. Biomol. NMR34:197-202(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 92-210
20.

"Solution structure of RSGI RUH-047, an FKBP domain from human cDNA."
RIKEN structural genomics initiative (RSGI)
Submitted (2006-06) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 91-205
21.

"Structure of the human FK-506 binding protein 8."
Structural genomics consortium (SGC)
Submitted (2006-10) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 90-205
22.

"A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding."
Maestre-Martinez M. , Haupt K. , Edlich F. , Neumann P. , Parthier C. , Stubbs M.T. , Fischer G. , Lucke C.
J. Mol. Recognit.24:23-34(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF 92-210;METAL-BINDING SITES;MUTAGENESIS OF ASP-149 AND ASP-151

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