Gene name:
WTAP (KIAA0105) ;
Protein name:
Pre-mRNA-splicing regulator WTAP ;
Alternative:
WT1-associated protein ;Female-lethal(2)D homolog (hFL(2)D) ;Wilms tumor 1-associating protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with WT1.
Function:
Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation.
Subcellular Location:
Nucleus
nucleolus
Protein Attributes:
50:
MTNEEPLPKK | VRLSETDFKV | MARDELILRW | KQYEAYVQAL | EGKYTDLNSN |
100:
DVTGLRESEE | KLKQQQQESA | RRENILVMRL | ATKEQEMQEC | TTQIQYLKQV |
150:
QQPSVAQLRS | TMVDPAINLF | FLKMKGELEQ | TKDKLEQAQN | ELSAWKFTPD |
200:
SQTGKKLMAK | CRMLIQENQE | LGRQLSQGRI | AQLEAELALQ | KKYSEELKSS |
250:
QDELNDFIIQ | LDEEVEGMQS | TILVLQQQLK | ETRQQLAQYQ | QQQSQASAPS |
300:
TSRTTASEPV | EQSEATSKDC | SRLTNGPSNG | SSSRQRTSGS | GFHREGNTTE |
350:
DDFPSSPGNG | NKSSNSSEER | TGRGGSGYVN | QLSAGYESVD | SPTGSENSLT |
396:
HQSNDTDSSH | DPQEEKAVSG | KGNRTVGSRH | VQNGLDSSVN | VQGSVL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Pre-mRNA-splicing regulator WTAP
ELISA Kit for Human Pre-mRNA-splicing regulator WTAP
CLIA Kit for Human Pre-mRNA-splicing regulator WTAP
CLIA Kit for Human Pre-mRNA-splicing regulator WTAP
Polyclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
Polyclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
Monoclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
Monoclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
Protein for Human Pre-mRNA-splicing regulator WTAP
Protein for Human Pre-mRNA-splicing regulator WTAP
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Placenta .
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Lung .
tissue :
Placenta .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1-9; 44-56; 72-79; 99-123; 163-173; 180-192; 234-253 AND 380-396;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Ovarian carcinoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 4-391 (ISOFORM 1);INTERACTION WITH WT1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue :
Fetal kidney .
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BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-396 (ISOFORM 1)
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Amygdala .
10.
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Proc. Natl. Acad. Sci. U.S.A.103:17278-17283(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
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Circ. Res.99:1338-1346(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH WT1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
15.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
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Santamaria A.
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Kumar C.
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,
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,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306 AND SER-388;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
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Polevoda B.
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Gazquez C.
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De Juan-Pardo E.
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Demeyer K.
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Hole K.
,
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,
Timmerman E.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE WMM COMPLEX