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Index > Protein center > WTAP(Gene name) > Human
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  • WTAP (Gene name),
  • Pre-mRNA-splicing regulator WTAP (Protein name ),  FL2D_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    WTAP(KIAA0105);
    Protein name:
    Pre-mRNA-splicing regulator WTAP;
    Alternative:
    WT1-associated protein;Female-lethal(2)D homolog(hFL(2)D);Wilms tumor 1-associating protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with WT1.
    Function:
    Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation.
    Subcellular Location:
    Nucleus nucleolus
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MTNEEPLPKK | VRLSETDFKV | MARDELILRW | KQYEAYVQAL | EGKYTDLNSN | 
    100:
    DVTGLRESEE | KLKQQQQESA | RRENILVMRL | ATKEQEMQEC | TTQIQYLKQV | 
    150:
    QQPSVAQLRS | TMVDPAINLF | FLKMKGELEQ | TKDKLEQAQN | ELSAWKFTPD | 
    200:
    SQTGKKLMAK | CRMLIQENQE | LGRQLSQGRI | AQLEAELALQ | KKYSEELKSS | 
    250:
    QDELNDFIIQ | LDEEVEGMQS | TILVLQQQLK | ETRQQLAQYQ | QQQSQASAPS | 
    300:
    TSRTTASEPV | EQSEATSKDC | SRLTNGPSNG | SSSRQRTSGS | GFHREGNTTE | 
    350:
    DDFPSSPGNG | NKSSNSSEER | TGRGGSGYVN | QLSAGYESVD | SPTGSENSLT | 
    396:
    HQSNDTDSSH | DPQEEKAVSG | KGNRTVGSRH | VQNGLDSSVN | VQGSVL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Pre-mRNA-splicing regulator WTAP
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    E1509h
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    ELISA Kit for Human Pre-mRNA-splicing regulator WTAP
    Cat.:
    E1509m
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    Packing:
    96T
    CLIA Kit for Human Pre-mRNA-splicing regulator WTAP
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    U1509h
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    Packing:
    96T
    CLIA Kit for Human Pre-mRNA-splicing regulator WTAP
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    U1509m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
    Cat.:
    P1509Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
    Cat.:
    P1509Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
    Monoclonal Antibody for Human Pre-mRNA-splicing regulator WTAP
    Protein for Human Pre-mRNA-splicing regulator WTAP
    Protein for Human Pre-mRNA-splicing regulator WTAP

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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing."
      Ortega A. , Niksic M. , Bachi A. , Wilm M. , Sanchez L. , Hastie N. , Valcarcel J.
      J. Biol. Chem.278:3040-3047(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T. , Miyajima N. , Tanaka A. , Sazuka T. , Seki N. , Sato S. , Tabata S. , Ishikawa K. , Kawarabayasi Y. , Kotani H. , Nomura N.
      DNA Res.2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Bone marrow.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Lung.
      tissue: Placenta.
    7. 7.
      Bienvenut W.V. , Lempens A. , Norman J.C.
      Submitted (2009-10) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-9; 44-56; 72-79; 99-123; 163-173; 180-192; 234-253 AND 380-396;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Ovarian carcinoma.
    8. 8.
      "Identification of WTAP, a novel Wilms' tumour 1-associating protein."
      Little N.A. , Hastie N.D. , Davies R.C.
      Hum. Mol. Genet.9:2231-2239(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-391 (ISOFORM 1);INTERACTION WITH WT1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Fetal kidney.
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-396 (ISOFORM 1)
      tissue: Amygdala.
    10. 10.
      "Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA."
      Horiuchi K. , Umetani M. , Minami T. , Okayama H. , Takada S. , Yamamoto M. , Aburatani H. , Reid P.C. , Housman D.E. , Hamakubo T. , Kodama T.
      Proc. Natl. Acad. Sci. U.S.A.103:17278-17283(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells."
      Small T.W. , Bolender Z. , Bueno C. , O'Neil C. , Nong Z. , Rushlow W. , Rajakumar N. , Kandel C. , Strong J. , Madrenas J. , Pickering J.G.
      Circ. Res.99:1338-1346(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH WT1
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306 AND SER-388;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase."
      Ping X.L. , Sun B.F. , Wang L. , Xiao W. , Yang X. , Wang W.J. , Adhikari S. , Shi Y. , Lv Y. , Chen Y.S. , Zhao X. , Li A. , Yang Y. , Dahal U. , Lou X.M. , Liu X. , Huang J. , Yuan W.P. , more...
      Cell Res.24:177-189(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE WMM COMPLEX
    20. 20.
      "A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation."
      Liu J. , Yue Y. , Han D. , Wang X. , Fu Y. , Zhang L. , Jia G. , Yu M. , Lu Z. , Deng X. , Dai Q. , Chen W. , He C.
      Nat. Chem. Biol.10:93-95(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE WMM COMPLEX
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