Gene name:
Flt3 (Flk-2;Flt-3) ;
Protein name:
Receptor-type tyrosine-protein kinase FLT3 ;
Alternative:
Fetal liver kinase 2 (FLK-2) ;FL cytokine receptor ;Tyrosine-protein kinase receptor flk-2 ;Fms-like tyrosine kinase 3 (FLT-3) ;
CD:
CD135 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer in the absence of bound FLT3LG. Homodimer in the presence of bound FLT3LG. One homodimer interacts with one FLT3LG molecule. Interacts with FIZ1 following ligand activation. Interacts with FES, FER and GRB2. Interacts with PTPRJ/DEP-1 and PTPN11/SHP2.
Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Endoplasmic reticulum lumen
Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
Protein Attributes:
50:
MRALAQRSDR | RLLLLVVLSV | MILETVTNQD | LPVIKCVLIS | HENNGSSAGK |
100:
PSSYRMVRGS | PEDLQCTPRR | QSEGTVYEAA | TVEVAESGSI | TLQVQLATPG |
150:
DLSCLWVFKH | SSLGCQPHFD | LQNRGIVSMA | ILNVTETQAG | EYLLHIQSER |
200:
ANYTVLFTVN | VRDTQLYVLR | RPYFRKMENQ | DALLCISEGV | PEPTVEWVLC |
250:
SSHRESCKEE | GPAVVRKEEK | VLHELFGTDI | RCCARNALGR | ECTKLFTIDL |
300:
NQAPQSTLPQ | LFLKVGEPLW | IRCKAIHVNH | GFGLTWELED | KALEEGSYFE |
350:
MSTYSTNRTM | IRILLAFVSS | VGRNDTGYYT | CSSSKHPSQS | ALVTILEKGF |
400:
INATSSQEEY | EIDPYEKFCF | SVRFKAYPRI | RCTWIFSQAS | FPCEQRGLED |
450:
GYSISKFCDH | KNKPGEYIFY | AENDDAQFTK | MFTLNIRKKP | QVLANASASQ |
500:
ASCSSDGYPL | PSWTWKKCSD | KSPNCTEEIP | EGVWNKKANR | KVFGQWVSSS |
550:
TLNMSEAGKG | LLVKCCAYNS | MGTSCETIFL | NSPGPFPFIQ | DNISFYATIG |
600:
LCLPFIVVLI | VLICHKYKKQ | FRYESQLQMI | QVTGPLDNEY | FYVDFRDYEY |
650:
DLKWEFPREN | LEFGKVLGSG | AFGRVMNATA | YGISKTGVSI | QVAVKMLKEK |
700:
ADSCEKEALM | SELKMMTHLG | HHDNIVNLLG | ACTLSGPVYL | IFEYCCYGDL |
750:
LNYLRSKREK | FHRTWTEIFK | EHNFSSYPTF | QAHSNSSMPG | SREVQLHPPL |
800:
DQLSGFNGNS | IHSEDEIEYE | NQKRLAEEEE | EDLNVLTFED | LLCFAYQVAK |
850:
GMEFLEFKSC | VHRDLAARNV | LVTHGKVVKI | CDFGLARDIL | SDSSYVVRGN |
900:
ARLPVKWMAP | ESLFEGIYTI | KSDVWSYGIL | LWEIFSLGVN | PYPGIPVDAN |
950:
FYKLIQSGFK | MEQPFYATEG | IYFVMQSCWA | FDSRKRPSFP | NLTSFLGCQL |
992:
AEAEEACIRT | SIHLPKQAAP | QQRGGLRAQS | PQRQVKIHRE | RS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Receptor-type tyrosine-protein kinase FLT3
ELISA Kit for Mouse Receptor-type tyrosine-protein kinase FLT3
CLIA Kit for Mouse Receptor-type tyrosine-protein kinase FLT3
CLIA Kit for Mouse Receptor-type tyrosine-protein kinase FLT3
Polyclonal Antibody for Mouse Receptor-type tyrosine-protein kinase FLT3
Polyclonal Antibody for Mouse Receptor-type tyrosine-protein kinase FLT3
Monoclonal Antibody for Mouse Receptor-type tyrosine-protein kinase FLT3
Monoclonal Antibody for Mouse Receptor-type tyrosine-protein kinase FLT3
Protein for Mouse Receptor-type tyrosine-protein kinase FLT3
Protein for Mouse Receptor-type tyrosine-protein kinase FLT3
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF DENDRITIC CELL DEVELOPMENT
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FIZ1;MUTAGENESIS OF LYS-645
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
"Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells."
Eidenschenk C.
,
Crozat K.
,
Krebs P.
,
Arens R.
,
Popkin D.
,
Arnold C.N.
,
Blasius A.L.
,
Benedict C.A.
,
Moresco E.M.
,
Xia Y.
,
Beutler B.
Proc. Natl. Acad. Sci. U.S.A.107:9759-9764(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF DENDRITIC CELL DEVELOPMENT
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;DOMAIN;ENZYME REGULATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RNF115 AND RNF126