FOS ELISA Kit for Human(Homo sapiens) | EIAab.comFOS ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FOS(Gene name) > Human

FOS (Gene name),

Proto-oncogene c-Fos (Protein name ), FOS_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FOS(G0S7);

Protein name:

Proto-oncogene c-Fos;

Alternative:

G0/G1 switch regulatory protein 7;Cellular oncogene fos;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

Function:

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

380

Sequence:

50:

100:

150:

200:

250:

300:

350:

380:

FPSCAAAHRK | GSSSNEPSSD | SLSSPTLLAL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P01100

UniGene:

Hs.25647

Pfam:

PF00170

STRING:

9606.ENSP00000306245

MIM:

164810

KEGG:

hsa:2353

SMR:

P01100

UniGene:

Hs.728789

Uniprot:

P01100

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ELISA Kit for Human Proto-oncogene c-Fos

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E1291h

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96T

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ELISA Kit for Human Proto-oncogene c-Fos

Cat.:

E1291m

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96T

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ELISA Kit for Human Proto-oncogene c-Fos

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E1291b

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96T

ELISA Kit for Human Proto-oncogene c-Fos

Cat.:

E1291r

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ELISA Kit for Human Proto-oncogene c-Fos

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E1291p

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96T

ELISA Kit for Human Proto-oncogene c-Fos

Cat.:

E1291c

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96T

CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291b

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96T

CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291c

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96T

CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291r

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96T

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CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291p

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MSDS:

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Packing:

96T

CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Proto-oncogene c-Fos

Cat.:

U1291h

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96T

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Polyclonal Antibody for Human Proto-oncogene c-Fos

Cat.:

P1291Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Proto-oncogene c-Fos

Cat.:

P1291Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Proto-oncogene c-Fos

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P1291Rb-r

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Monoclonal Antibody for Human Proto-oncogene c-Fos

Protein for Human Proto-oncogene c-Fos

Cat.:

R1291h

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Packing:

1mg

Purity:

>90%

Protein for Human Proto-oncogene c-Fos

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein."
van Straaten F. , Mueller R. , Curran T. , Van Beveren C. , Verma I.M.
Proc. Natl. Acad. Sci. U.S.A.80:3183-3187(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Colon.
4.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Pancreas.
7.

"Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells."
Roux P. , Verrier B. , Klein B. , Niccolino M. , Marty L. , Alexandre C. , Piechaczyk M.
Oncogene6:2155-2160(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-6 (ISOFORM 1/2)
8.

"Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
Hai T. , Liu F. , Coukos W.J. , Green M.R.
Genes Dev.3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 133-200 (ISOFORM 1);DNA-BINDING;SUBUNIT
9.

Hai T. , Liu F. , Coukos W.J. , Green M.R.
Genes Dev.4:682-682(1990)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"The basic region of Fos mediates specific DNA binding."
Nakabeppu Y. , Nathans D.
EMBO J.8:3833-3841(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
11.

"The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells."
Okazaki K. , Sagata N.
EMBO J.14:5048-5059(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF SER-362 AND SER-374
12.

"Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription."
Zhang Y. , Feng X.H. , Derynck R.
Nature394:909-913(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS A COMPONENT OF THE SMAD3/SMAD4/JUN/FOS COMPLEX;FUNCTION;INTERACTION WITH SMAD3
13.

"Molecular interpretation of ERK signal duration by immediate early gene products."
Murphy L.O. , Smith S. , Chen R.H. , Fingar D.C. , Blenis J.
Nat. Cell Biol.4:556-564(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-325; THR-331 AND SER-374
14.

"Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation."
Bossis G. , Malnou C.E. , Farras R. , Andermarcher E. , Hipskind R. , Rodriguez M. , Schmidt D. , Muller S. , Jariel-Encontre I. , Piechaczyk M.
Mol. Cell. Biol.25:6964-6979(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-265;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF LYS-128; LYS-192; LYS-265; THR-325; THR-331; SER-362 AND SER-374
15.

"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
Vasilescu J. , Zweitzig D.R. , Denis N.J. , Smith J.C. , Ethier M. , Haines D.S. , Figeys D.
J. Proteome Res.6:298-305(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-113
tissue: Lung adenocarcinoma.
16.

"Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."
Jakobs A. , Himstedt F. , Funk M. , Korn B. , Gaestel M. , Niedenthal R.
Nucleic Acids Res.35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
17.

"N-Terminal c-Fos tyrosine phosphorylation regulates c-Fos/ER association and c-Fos-dependent phospholipid synthesis activation."
Portal M.M. , Ferrero G.O. , Caputto B.L.
Oncogene26:3551-3558(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;PHOSPHORYLATION AT TYR-10 AND TYR-30;MUTAGENESIS OF TYR-10; TYR-30; TYR-106 AND TYR-337
18.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
19.

"The kinase c-Src and the phosphatase TC45 coordinately regulate c-Fos tyrosine phosphorylation and c-Fos phospholipid synthesis activation capacity."
Ferrero G.O. , Velazquez F.N. , Caputto B.L.
Oncogene31:3381-3391(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT TYR-10 AND TYR-30;MUTAGENESIS OF TYR-10 AND TYR-30
20.

"Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA."
Glover J.N. , Harrison S.C.
Nature373:257-261(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 139-198 OF COMPLEX WITH JUN

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