Protein name:
Proto-oncogene c-Fos ;
Alternative:
Cellular oncogene fos ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer; with JUN (By similarity). Interacts with MAFB. Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB (By similarity). Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.
Function:
Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MMFSGFNADY | EASSSRCSSA | SPAGDSLSYY | HSPADSFSSM | GSPVNTQDFC |
100:
ADLSVSSANF | IPTVTAISTS | PDLQWLVQPT | LVSSVAPSQT | RAPHPYGLPT |
150:
QSAGAYARAG | MVKTVSGGRA | QSIGRRGKVE | QLSPEEEEKR | RIRRERNKMA |
200:
AAKCRNRRRE | LTDTLQAETD | QLEDEKSALQ | TEIANLLKEK | EKLEFILAAH |
250:
RPACKIPDDL | GFPEEMSVAS | LDLTGGLPEA | STPESEEAFT | LPLLNDPEPK |
300:
PSLEPVKSIS | NVELKAEPFD | DFLFPASSRP | SGSETSRSVP | DVDLSGSFYA |
350:
ADWEPLHSNS | LGMGPMVTEL | EPLCTPVVTC | TPGCTTYTSS | FVFTYPEADS |
380:
FPSCAAAHRK | GSSSNEPSSD | SLSSPTLLAL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Pig
Chicken
ELISA Kit for Mouse Proto-oncogene c-Fos
ELISA Kit for Mouse Proto-oncogene c-Fos
ELISA Kit for Mouse Proto-oncogene c-Fos
ELISA Kit for Mouse Proto-oncogene c-Fos
ELISA Kit for Mouse Proto-oncogene c-Fos
ELISA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
CLIA Kit for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Polyclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Monoclonal Antibody for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
Protein for Mouse Proto-oncogene c-Fos
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary gland .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DSIPI
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-325; THR-331; SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF THR-325; THR-331; PHE-343; TYR-345; SER-362 AND SER-374
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-232; THR-325; THR-331; SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF THR-232; THR-325; THR-331 AND SER-374
7.
"Essential role of RSK2 in c-Fos-dependent osteosarcoma development."
David J.-P.
,
Mehic D.
,
Bakiri L.
,
Schilling A.F.
,
Mandic V.
,
Priemel M.
,
Idarraga M.H.
,
Reschke M.O.
,
Hoffmann O.
,
Amling M.
,
Wagner E.F.
J. Clin. Invest.115:664-672(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-362;FUNCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CDS1 AND PI4K2A;TYROSINE PHOSPHORYLATION BY SRC;MUTAGENESIS OF LYS-139; ARG-144 AND ARG-146