Fos ELISA Kit for Rat(Rattus norvegicus) | EIAab.comFos ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Fos(Gene name) > Rat

Fos (Gene name),

Proto-oncogene c-Fos (Protein name ), FOS_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fos;

Protein name:

Proto-oncogene c-Fos;

Alternative:

Cellular oncogene fos;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer; with JUN (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA (By similarity). Interacts with MAFB.

Function:

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

380

Sequence:

50:

100:

150:

200:

250:

300:

350:

380:

FPSCAAAHRK | GSSSNEPSSD | SLSSPTLLAL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00170

KEGG:

rno:314322

UniGene:

Rn.103750

String:

P12841

SMR:

P12841

Uniprot:

P12841

FOR

ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291h

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96T

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ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291m

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96T

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ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291b

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Packing:

96T

ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291r

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96T

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ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291p

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96T

ELISA Kit for Rat Proto-oncogene c-Fos

Cat.:

E1291c

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Packing:

96T

CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291b

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MSDS:

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96T

CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291c

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96T

CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291r

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96T

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CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291p

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MSDS:

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Packing:

96T

CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat Proto-oncogene c-Fos

Cat.:

U1291h

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Rat Proto-oncogene c-Fos

Cat.:

P1291Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Proto-oncogene c-Fos

Cat.:

P1291Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Proto-oncogene c-Fos

Cat.:

P1291Rb-r

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40ug/0.2ml

Monoclonal Antibody for Rat Proto-oncogene c-Fos

Protein for Rat Proto-oncogene c-Fos

Cat.:

R1291h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Rat Proto-oncogene c-Fos

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation and characterization of the c-fos(rat) cDNA and analysis of post-translational modification in vitro."
Curran T. , Gordon M.B. , Rubino K.L. , Sambucetti L.C.
Oncogene2:79-84(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"cFOS expression in rat."
Weiler E.
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Sprague-Dawley.
tissue: Liver.
3.

"Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly."
Abate C. , Luk D. , Gentz R. , Rauscher F.J. III , Curran T.
Proc. Natl. Acad. Sci. U.S.A.87:1032-1036(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING
4.

"Rat maf-related factors: the specificities of DNA binding and heterodimer formation."
Matsushima-Hibiya Y. , Nishi S. , Sakai M.
Biochem. Biophys. Res. Commun.245:412-418(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAFB
5.

"Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity."
Bannister A.J. , Brown H.J. , Sutherland J.A. , Kouzarides T.
Nucleic Acids Res.22:5173-5176(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-232;FUNCTION;MUTAGENESIS OF THR-232
6.

"Sustained activation of extracellular signal-regulated kinase by nerve growth factor regulates c-fos protein stabilization and transactivation in PC12 cells."
Pellegrino M.J. , Stork P.J.
J. Neurochem.99:1480-1493(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-325; THR-331; SER-362 AND SER-374;FUNCTION;MUTAGENESIS OF THR-325; THR-331; 343-PHE--TYR-345; SER-362 AND SER-374

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