Forkhead box protein O3 (Protein name
), FOXO3_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
FOXO3(FKHRL1;FOXO3A);
Protein name:
Forkhead box protein O3;
Alternative:
Forkhead in rhabdomyosarcoma-like 1;AF6q21 protein;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1.
Function:
Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-383 (ISOFORM 1);INVOLVEMENT IN SECONDARY ACUTE LEUKEMIAS
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Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-32; SER-253 AND SER-315;MUTAGENESIS OF THR-32; SER-253 AND SER-315
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Cited for: FUNCTION;PHOSPHORYLATION AT SER-209;INTERACTION WITH STK4/MST1 AND YWHAB;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-209
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Cited for: PHOSPHORYLATION AT THR-179; SER-399; SER-413; SER-555; SER-588 AND SER-626;MUTAGENESIS OF THR-179; SER-399; SER-413; SER-555; SER-588 AND SER-626;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280 AND SER-284;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;PHOSPHORYLATION AT SER-215; SER-253; SER-551 AND SER-555
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Cited for: METHYLATION AT LYS-46; LYS-149; LYS-230; LYS-262; LYS-271; LYS-290 AND LYS-419;MUTAGENESIS OF LYS-269; LYS-270 AND LYS-271
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Cited for: ACETYLATION;DEACETYLATION BY SIRT2;INTERACTION WITH SKP2;UBIQUITINATION BY SKP2;MUTAGENESIS OF LYS-242; LYS-259; LYS-290 AND LYS-569
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Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 158-253 IN COMPLEX WITH DNA;MUTAGENESIS OF LYS-242 AND LYS-245;NUCLEAR LOCALIZATION SIGNAL
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