FOXO3 ELISA Kit for Human(Homo sapiens) | EIAab.comFOXO3 ELISA Kit for Human(Homo sapiens)

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FOXO3 (Gene name),

Forkhead box protein O3 (Protein name ), FOXO3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FOXO3(FKHRL1;FOXO3A);

Protein name:

Forkhead box protein O3;

Alternative:

Forkhead in rhabdomyosarcoma-like 1;AF6q21 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1.

Function:

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.

Subcellular Location:

Cytoplasm cytosol Nucleus Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Protein Attributes:

Sequence length:

673

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

673:

VVGLNVGNFT | GAKQASSQSW | VPG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

602681

KEGG:

hsa:2309

SMR:

O43524

STRING:

9606.ENSP00000339527

String:

O43524

Pfam:

PF00250

UniGene:

Hs.220950

Uniprot:

O43524

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ELISA Kit for Human Forkhead box protein O3

Cat.:

E0762h

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96T

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ELISA Kit for Human Forkhead box protein O3

Cat.:

E0762m

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96T

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CLIA Kit for Human Forkhead box protein O3

Cat.:

U0762h

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96T

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CLIA Kit for Human Forkhead box protein O3

Cat.:

U0762m

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Packing:

96T

Polyclonal Antibody for Human Forkhead box protein O3

Cat.:

P0762Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Forkhead box protein O3

Cat.:

P0762Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Forkhead box protein O3

Protein for Human Forkhead box protein O3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily."
Anderson M.J. , Viars C.S. , Czekay S. , Cavenee W.K. , Arden K.C.
Genomics47:187-199(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Rhabdomyosarcoma.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Stomach.
3.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Muscle.
tissue: Placenta.
6.

"AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily."
Hillion J. , Le Coniat M. , Jonveaux P. , Berger R. , Bernard O.A.
Blood90:3714-3719(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-383 (ISOFORM 1);INVOLVEMENT IN SECONDARY ACUTE LEUKEMIAS
7.

"Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor."
Brunet A. , Bonni A. , Zigmond M.J. , Lin M.Z. , Juo P. , Hu L.S. , Anderson M.J. , Arden K.C. , Blenis J. , Greenberg M.E.
Cell96:857-868(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-32; SER-253 AND SER-315;MUTAGENESIS OF THR-32; SER-253 AND SER-315
8.

"Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)."
Brunet A. , Park J. , Tran H. , Hu L.S. , Hemmings B.A. , Greenberg M.E.
Mol. Cell. Biol.21:952-965(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-315
9.

"A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span."
Lehtinen M.K. , Yuan Z. , Boag P.R. , Yang Y. , Villen J. , Becker E.B.E. , DiBacco S. , de la Iglesia N. , Gygi S.P. , Blackwell T.K. , Bonni A.
Cell125:987-1001(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-209;INTERACTION WITH STK4/MST1 AND YWHAB;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-209
10.

"The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor."
Greer E.L. , Oskoui P.R. , Banko M.R. , Maniar J.M. , Gygi M.P. , Gygi S.P. , Brunet A.
J. Biol. Chem.282:30107-30119(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-179; SER-399; SER-413; SER-555; SER-588 AND SER-626;MUTAGENESIS OF THR-179; SER-399; SER-413; SER-555; SER-588 AND SER-626;SUBCELLULAR LOCATION
11.

"Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels."
Morishita D. , Katayama R. , Sekimizu K. , Tsuruo T. , Fujita N.
Cancer Res.68:5076-5085(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIM1;PHOSPHORYLATION
12.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280 AND SER-284;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-280;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis."
Kress T.R. , Cannell I.G. , Brenkman A.B. , Samans B. , Gaestel M. , Roepman P. , Burgering B.M. , Bushell M. , Rosenwald A. , Eilers M.
Mol. Cell41:445-457(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DNA-BINDING;PHOSPHORYLATION AT SER-215; SER-253; SER-551 AND SER-555
18.

"Methylation by Set9 modulates FoxO3 stability and transcriptional activity."
Calnan D.R. , Webb A.E. , White J.L. , Stowe T.R. , Goswami T. , Shi X. , Espejo A. , Bedford M.T. , Gozani O. , Gygi S.P. , Brunet A.
Aging (Albany NY)4:462-479(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-46; LYS-149; LYS-230; LYS-262; LYS-271; LYS-290 AND LYS-419;MUTAGENESIS OF LYS-269; LYS-270 AND LYS-271
19.

"Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation."
Wang F. , Chan C.H. , Chen K. , Guan X. , Lin H.K. , Tong Q.
Oncogene31:1546-1557(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION BY SIRT2;INTERACTION WITH SKP2;UBIQUITINATION BY SKP2;MUTAGENESIS OF LYS-242; LYS-259; LYS-290 AND LYS-569
20.

"CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."
Ghosh A.P. , Klocke B.J. , Ballestas M.E. , Roth K.A.
PLoS ONE7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDIT3;SUBCELLULAR LOCATION
21.

"Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification."
Tsai K.-L. , Sun Y.-J. , Huang C.-Y. , Yang J.-Y. , Hung M.-C. , Hsiao C.-D.
Nucleic Acids Res.35:6984-6994(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 158-253 IN COMPLEX WITH DNA;MUTAGENESIS OF LYS-242 AND LYS-245;NUCLEAR LOCALIZATION SIGNAL

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