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Index > Protein center > FOXP3(Gene name) > Human
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  • FOXP3 (Gene name),
  • Forkhead box protein P3 (Protein name ),  FOXP3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FOXP3(JM2;IPEX);
    Protein name:
    Forkhead box protein P3;
    Alternative:
    Scurfin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with IKZF3.
    Function:
    Probable transcription factor. Plays a critical role in the control of immune response.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    431
    Sequence:
    50:
    MPNPRPGKPS | APSLALGPSP | GASPSWRAAP | KASDLLGARG | PGGTFQGRDL | 
    100:
    RGGAHASSSS | LNPMPPSQLQ | LPTLPLVMVA | PSGARLGPLP | HLQALLQDRP | 
    150:
    HFMHQLSTVD | AHARTPVLQV | HPLESPAMIS | LTPPTTATGV | FSLKARPGLP | 
    200:
    PGINVASLEW | VSREPALLCT | FPNPSAPRKD | STLSAVPQSS | YPLLANGVCK | 
    250:
    WPGCEKVFEE | PEDFLKHCQA | DHLLDEKGRA | QCLLQREMVQ | SLEQQLVLEK | 
    300:
    EKLSAMQAHL | AGKMALTKAS | SVASSDKGSC | CIVAAGSQGP | VVPAWSGPRE | 
    350:
    APDSLFAVRR | HLWGSHGNST | FPEFLHNMDY | FKFHNMRPPF | TYATLIRWAI | 
    400:
    LEAPEKQRTL | NEIYHWFTRM | FAFFRNHPAT | WKNAIRHNLS | LHKCFVRVES | 
    431:
    EKGAVWTVDE | LEFRKKRSQR | PSRCSNPTPG | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    KEGG:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Forkhead box protein P3
    Cat.:
    E1877h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Forkhead box protein P3
    Cat.:
    E1877m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Forkhead box protein P3
    Cat.:
    U1877m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Forkhead box protein P3
    Cat.:
    U1877h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Forkhead box protein P3
    Cat.:
    P1877Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Forkhead box protein P3
    Cat.:
    P1877Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Forkhead box protein P3
    Monoclonal Antibody for Human Forkhead box protein P3
    Protein for Human Forkhead box protein P3
    Protein for Human Forkhead box protein P3

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse."
      Brunkow M.E. , Jeffery E.W. , Hjerrild K.A. , Paeper B. , Clark L.B. , Yasayko S.-A. , Wilkinson J.E. , Galas D. , Ziegler S.F. , Ramsdell F.
      Nat. Genet.27:68-73(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Cloning and expression of the cDNA for FOXP3."
      Wang J. , Liu Q. , Zhang Y. , Xu Z. , Huang C.
      Submitted (2007-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Functional characterization of FOXP3 splice variants in human regulatory T cells."
      Kaur G. , Goodall J.C. , Jarvis L.B. , Gaston J.S.H.
      Submitted (2008-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    4. 4.
      Lin L. , Nong W. , Li H. , Ke R. , Shen C. , Zhong G. , Zheng Z. , Liang M. , Huang B. , Zhou G. , Yang S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    7. 7.
      "Transcription map in Xp11.23."
      Strom T.M. , Nyakatura G. , Hellebrand H. , Drescher B. , Rosenthal A. , Meindl A.
      Submitted (1998-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-431 (ISOFORM 3)
    8. 8.
      "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells."
      Gandhi R. , Kumar D. , Burns E.J. , Nadeau M. , Dake B. , Laroni A. , Kozoriz D. , Weiner H.L. , Quintana F.J.
      Nat. Immunol.11:846-853(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKZF3
    9. 9.
      "Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells."
      Kwon H.S. , Lim H.W. , Wu J. , Schnolzer M. , Verdin E. , Ott M.
      J. Immunol.188:2712-2721(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-31; LYS-263 AND LYS-268;DEACETYLATION BY SIRT1
    10. 10.
      "JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome."
      Chatila T.A. , Blaeser F. , Ho N. , Lederman H.M. , Voulgaropoulos C. , Helms C. , Bowcock A.M.
      J. Clin. Invest.106:R75-R81(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IPEX GLU-251 DEL
    11. 11.
      "Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)."
      Kobayashi I. , Shiari R. , Yamada M. , Kawamura N. , Okano M. , Yara A. , Iguchi A. , Ishikawa N. , Ariga T. , Sakiyama Y. , Ochs H.D. , Kobayashi K.
      J. Med. Genet.38:874-876(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IPEX VAL-363
    12. 12.
      "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy."
      Wildin R.S. , Ramsdell F. , Peake J. , Faravelli F. , Casanova J.-L. , Buist N. , Levy-Lahad E. , Mazzella M. , Goulet O. , Perroni L. , Bricarelli F.D. , Byrne G. , McEuen M. , Proll S. , Appleby M. , Brunkow M.E.
      Nat. Genet.27:18-20(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS IPEX CYS-371; THR-384 AND TRP-397
    13. 13.
      "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3."
      Bennett C.L. , Christie J. , Ramsdell F. , Brunkow M.E. , Ferguson P.J. , Whitesell L. , Kelly T.E. , Saulsbury F.T. , Chance P.F. , Ochs H.D.
      Nat. Genet.27:20-21(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT IPEX THR-384
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