FSCN1 ELISA Kit for Human(Homo sapiens) | EIAab.comFSCN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FSCN1(Gene name) > Human

FSCN1 (Gene name),

Fascin (Protein name ), FSCN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

FSCN1(FAN1;HSN;SNL);

Protein name:

Fascin;

Alternative:

Singed-like protein;55 kDa actin-bundling protein;p55;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associates with beta-catenin.

Function:

Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.

Subcellular Location:

Cytoplasm cytoskeleton Cell projection filopodium Cell projection invadopodium

Protein Attributes:

Sequence length:

493

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

493:

FFFEFCDYNK | VAIKVGGRYL | KGDHAGVLKA | SAETVDPASL | WEY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF06268

SMR:

Q16658

UniGene:

Hs.118400

String:

Q16658

MIM:

602689

STRING:

9606.ENSP00000371798

KEGG:

hsa:6624

Uniprot:

Q16658

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ELISA Kit for Human Fascin

Cat.:

E1757h

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96T

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ELISA Kit for Human Fascin

Cat.:

E1757r

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96T

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ELISA Kit for Human Fascin

Cat.:

E1757m

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96T

CLIA Kit for Human Fascin

Cat.:

U1757r

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96T

CLIA Kit for Human Fascin

Cat.:

U1757h

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Looking for manual.

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96T

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CLIA Kit for Human Fascin

Cat.:

U1757m

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96T

Polyclonal Antibody for Human Fascin

Cat.:

P1757Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Fascin

Cat.:

P1757Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Fascin

Cat.:

P1757Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Fascin

Protein for Human Fascin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Differential associations of circulating peroxiredoxins levels with indicators of glycemic control in type 2 diabetes mellitus"

AA Al-Masri, E El Eter, S Tayel, et al.

From:Eur Rev Med Pharmacol Sci

References

1.

"cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein."
Duh F.-M. , Latif F. , Weng Y. , Geil L. , Modi W. , Stackhouse T. , Matsumura F. , Duan D.R. , Linehan W.M. , Lerman M.I. , Gnarra J.R.
DNA Cell Biol.13:821-827(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Teratocarcinoma.
2.

"Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein."
Mosialos G. , Yamashiro S. , Baughman R.W. , Matsudaira P. , Vara L. , Matsumura F. , Kieff E. , Birkenbach M.
J. Virol.68:7320-7328(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Human fascin gene sequence."
Bros M. , Ross X.L. , Reske-Kunz A.B. , Ross R.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Eye.
tissue: Lung.
tissue: Muscle.
9.

Bienvenut W.V.
Submitted (2010-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-32; 44-63; 69-82; 111-149; 159-185; 202-217; 230-241; 248-271; 314-341; 409-426 AND 469-493;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT THR-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Ovarian carcinoma.
10.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 119-149; 202-217; 230-241; 314-330 AND 380-389;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
11.

"Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin."
Yamashiro-Matsumura S. , Matsumura F.
J. Cell Biol.103:631-640(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"Phosphorylation of human fascin inhibits its actin binding and bundling activities."
Yamakita Y. , Ono S. , Matsumura F. , Yamashiro S.
J. Biol. Chem.271:12632-12638(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
13.

"Characterization of cell-matrix adhesion requirements for the formation of fascin microspikes."
Adams J.C.
Mol. Biol. Cell8:2345-2363(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells."
Yamashiro S. , Yamakita Y. , Ono S. , Matsumura F.
Mol. Biol. Cell9:993-1006(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
15.

"Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin."
Ono S. , Yamakita Y. , Yamashiro S. , Matsudaira P.T. , Gnarra J.R. , Obinata T. , Matsumura F.
J. Biol. Chem.272:2527-2533(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-39;MUTAGENESIS OF SER-39
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion."
Li A. , Dawson J.C. , Forero-Vargas M. , Spence H.J. , Yu X. , Konig I. , Anderson K. , Machesky L.M.
Curr. Biol.20:339-345(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V. , Sumpton D. , Martinez A. , Lilla S. , Espagne C. , Meinnel T. , Giglione C.
Mol. Cell. Proteomics11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton."
Li X. , Law J.W. , Lee A.Y.
Oncogene31:595-610(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLXNB3;SUBCELLULAR LOCATION
22.

"Structure, evolutionary conservation, and conformational dynamics of Homo sapiens fascin-1, an F-actin crosslinking protein."
Sedeh R.S. , Fedorov A.A. , Fedorov E.V. , Ono S. , Matsumura F. , Almo S.C. , Bathe M.
J. Mol. Biol.400:589-604(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS);DOMAIN
23.

"Migrastatin analogues target fascin to block tumour metastasis."
Chen L. , Yang S. , Jakoncic J. , Zhang J.J. , Huang X.Y.
Nature464:1062-1066(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS);FUNCTION;MUTAGENESIS OF HIS-392; LYS-471 AND ALA-488;DOMAIN

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