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Index > Protein center > GABRA2(Gene name) > Human
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  • GABRA2 (Gene name),
  • Gamma-aminobutyric acid receptor subunit alpha-2 (Protein name ),  GBRA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GABRA2;
    Protein name:
    Gamma-aminobutyric acid receptor subunit alpha-2;
    Alternative:
    GABA(A) receptor subunit alpha-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
    Function:
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    451
    Sequence:
    50:
    MKTKLNIYNM | QFLLFVFLVW | DPARLVLANI | QEDEAKNNIT | IFTRILDRLL | 
    100:
    DGYDNRLRPG | LGDSITEVFT | NIYVTSFGPV | SDTDMEYTID | VFFRQKWKDE | 
    150:
    RLKFKGPMNI | LRLNNLMASK | IWTPDTFFHN | GKKSVAHNMT | MPNKLLRIQD | 
    200:
    DGTLLYTMRL | TVQAECPMHL | EDFPMDAHSC | PLKFGSYAYT | TSEVTYIWTY | 
    250:
    NASDSVQVAP | DGSRLNQYDL | LGQSIGKETI | KSSTGEYTVM | TAHFHLKRKI | 
    300:
    GYFVIQTYLP | CIMTVILSQV | SFWLNRESVP | ARTVFGVTTV | LTMTTLSISA | 
    350:
    RNSLPKVAYA | TAMDWFIAVC | YAFVFSALIE | FATVNYFTKR | GWAWDGKSVV | 
    400:
    NDKKKEKASV | MIQNNAYAVA | VANYAPNLSK | DPVLSTISKS | ATTPEPNKKP | 
    450:
    ENKPAEAKKT | FNSVSKIDRM | SRIVFPVLFG | TFNLVYWATY | LNREPVLGVS | 
    451:
    P
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    KEGG:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    E0464m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    E0464b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    E0464h
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    MSDS:
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    96T
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    ELISA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    E0464r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    U0464m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    U0464r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    U0464h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    U0464b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    P0464Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    P0464Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Polyclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Cat.:
    P0464Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Monoclonal Antibody for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Protein for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Protein for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Protein for Human Gamma-aminobutyric acid receptor subunit alpha-2
    Protein for Human Gamma-aminobutyric acid receptor subunit alpha-2

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors."
      Hadingham K.L. , Wingrove P. , le Bourdelles B. , Palmer K.J. , Ragan C.I. , Whiting P.J.
      Mol. Pharmacol.43:970-975(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Amygdala.
      tissue: Brain.
      tissue: Cerebellum.
    4. 4.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations."
      Edenberg H.J. , Dick D.M. , Xuei X. , Tian H. , Almasy L. , Bauer L.O. , Crowe R.R. , Goate A. , Hesselbrock V. , Jones K. , Kwon J. , Li T.-K. , Nurnberger J.I. Jr. , O'Connor S.J. , Reich T. , Rice J. , Schuckit M.A. , Porjesz B. , more...
      Am. J. Hum. Genet.74:705-714(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM
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