Nr3c1 ELISA Kit for Mouse(Mus musculus) | EIAab.comNr3c1 ELISA Kit for Mouse(Mus musculus)

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Nr3c1 (Gene name),

Glucocorticoid receptor (Protein name ), GCR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nr3c1(Grl;Grl1);

Protein name:

Glucocorticoid receptor(GR);

Alternative:

Nuclear receptor subfamily 3 group C member 1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1.

Function:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic in the absence of ligand, nuclear after ligand-binding. The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment.

Protein Attributes:

Sequence length:

783

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

783:

MSIEFPEMLA | EIITNQIPKY | SNGNIKKLLF | HQK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P06537

UniGene:

Mm.129481

Pfam:

PF02155

SMR:

P06537

Uniprot:

P06537

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ELISA Kit for Mouse GR

Cat.:

E1608h

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Packing:

96T

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ELISA Kit for Mouse GR

Cat.:

E1608r

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96T

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ELISA Kit for Mouse GR

Cat.:

E1608m

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96T

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ELISA Kit for Mouse GR

Cat.:

E1608p

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Packing:

96T

ELISA Kit for Mouse GR

MSDS:

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CLIA Kit for Mouse GR

Cat.:

U1608p

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GR

Cat.:

U1608m

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96T

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CLIA Kit for Mouse GR

MSDS:

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CLIA Kit for Mouse GR

Cat.:

U1608r

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Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse GR

Cat.:

U1608h

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Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Mouse GR

Cat.:

P1608Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GR

Cat.:

P1608Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse GR

Cat.:

P1608Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse GR

Protein for Mouse GR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The mouse glucocorticoid receptor: mapping of functional domains by cloning, sequencing and expression of wild-type and mutant receptor proteins."
Danielsen M. , Northrop J.P. , Ringold G.M.
EMBO J.5:2513-2522(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Novel cDNA sequence possibly generated by alternative splicing of a mouse glucocorticoid receptor gene transcript from Shionogi carcinoma 115."
Nohno T. , Kasai Y. , Saito T.
Nucleic Acids Res.17:445-445(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-755 (ISOFORMS 1 AND 2)
3.

"Regulation of glucocorticoid receptor protein and mRNA levels."
Vedeckis W.V. , Ali M. , Allen H.R.
Cancer Res.49:2295-2302(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLUCOCORTICOID-MEDIATED DOWN-REGULATION
4.

"Identification of phosphorylated sites in the mouse glucocorticoid receptor."
Bodwell J.E. , Orti E. , Coull J.M. , Pappin D.J.C. , Smith L.I. , Swift F.
J. Biol. Chem.266:7549-7555(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-122; SER-150; THR-159; SER-212; SER-220; SER-234 AND SER-315
5.

"Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin."
Silverstein A.M. , Galigniana M.D. , Chen M.S. , Owens-Grillo J.K. , Chinkers M. , Pratt W.B.
J. Biol. Chem.272:16224-16230(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH NR3C1 AND FKBP4; PPID; PPP5C OR STIP1
6.

"Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells."
Cella N. , Groner B. , Hynes N.E.
Mol. Cell. Biol.18:1783-1792(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STA5A AND STAT5B
7.

"Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression."
Chang C.J. , Chen Y.L. , Lee S.C.
Mol. Cell. Biol.18:5880-5887(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM28
8.

"Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix."
Yang L. , Guerrero J. , Hong H. , DeFranco D.B. , Stallcup M.R.
Mol. Biol. Cell11:2007-2018(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
9.

"The glucocorticoid receptor: rapid exchange with regulatory sites in living cells."
McNally J.G. , Mueller W.G. , Walker D. , Wolford R. , Hager G.L.
Science287:1262-1265(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION OF REGULATORY PROTEINS WITH TARGET SITES IN CHROMATIN
10.

"Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus."
Galigniana M.D. , Radanyi C. , Renoir J.-M. , Housley P.R. , Pratt W.B.
J. Biol. Chem.276:14884-14889(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;HETEROMULTIMERIC COMPLEX FORMATION;INTERACTION WITH FKBP4;MECHANISM OF TRANSLOCATION TO THE NUCLEUS
11.

"Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids."
Wallace A.D. , Cidlowski J.A.
J. Biol. Chem.276:42714-42721(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-426;MUTAGENESIS OF LYS-426;GLUCOCORTICOID-MEDIATED DOWN-REGULATION
12.

"Molecular identification and characterization of A and B forms of the glucocorticoid receptor."
Yudt M.R. , Cidlowski J.A.
Mol. Endocrinol.15:1093-1103(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;MUTAGENESIS OF MET-1 AND MET-28
13.

"A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins."
Davies T.H. , Ning Y.M. , Sanchez E.R.
J. Biol. Chem.277:4597-4600(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETEROMULTIMERIC COMPLEX FORMATION;MECHANISM OF TRANSLOCATION TO THE NUCLEUS
14.

"T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation."
Brewer J.A. , Khor B. , Vogt S.K. , Muglia L.M. , Fujiwara H. , Haegele K.E. , Sleckman B.P. , Muglia L.J.
Nat. Med.9:1318-1322(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMMUNE SYSTEM DEVELOPMENT
15.

"Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth."
Tronche F. , Opherk C. , Moriggl R. , Kellendonk C. , Reimann A. , Schwake L. , Reichardt H.M. , Stangl K. , Gau D. , Hoeflich A. , Beug H. , Schmid W. , Schuetz G.
Genes Dev.18:492-497(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION IN THE CONTROL OF BODY GROWTH
16.

"Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-? (PPAR?)."
Hinds T.D. Jr. , Stechschulte L.A. , Cash H.A. , Whisler D. , Banerjee A. , Yong W. , Khuder S.S. , Kaw M.K. , Shou W. , Najjar S.M. , Sanchez E.R.
J. Biol. Chem.286:42911-42922(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ADIPOGENESIS;INTERACTION WITH FKBP5 AND PPP5C;PHOSPHORYLATION AT SER-212; SER-220 AND SER-234;DEPHOSPHORYLATION AT SER-212 AND SER-234 BY PPP5C
17.

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Lamia K.A. , Papp S.J. , Yu R.T. , Barish G.D. , Uhlenhaut N.H. , Jonker J.W. , Downes M. , Evans R.M.
Nature480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1 AND CRY2
18.

"A novel protein, CHRONO, functions as a core component of the mammalian circadian clock."
Goriki A. , Hatanaka F. , Myung J. , Kim J.K. , Yoritaka T. , Tanoue S. , Abe T. , Kiyonari H. , Fujimoto K. , Kato Y. , Todo T. , Matsubara A. , Forger D. , Takumi T.
PLoS Biol.12:E1001839-E1001839(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CIART

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