Nr3c1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comNr3c1 ELISA Kit for Rat(Rattus norvegicus)

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Nr3c1 (Gene name),

Glucocorticoid receptor (Protein name ), GCR_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nr3c1(Grl);

Protein name:

Glucocorticoid receptor(GR);

Alternative:

Nuclear receptor subfamily 3 group C member 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, TGFB1I1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1 (By similarity). Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1.

Function:

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.

Subcellular Location:

Cytoplasm Nucleus Cytoplasmic in the absence of ligand, nuclear after ligand-binding.

Protein Attributes:

Sequence length:

795

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

795:

LTYCFQTFLD | KTMSIEFPEM | LAEIITNQIP | KYSNGNIKKL | LFHQK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.90070

String:

P06536

KEGG:

rno:24413

Pfam:

PF02155

SMR:

P06536

Uniprot:

P06536

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ELISA Kit for Rat GR

Cat.:

E1608h

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96T

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ELISA Kit for Rat GR

Cat.:

E1608r

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96T

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ELISA Kit for Rat GR

Cat.:

E1608m

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96T

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ELISA Kit for Rat GR

Cat.:

E1608p

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96T

ELISA Kit for Rat GR

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CLIA Kit for Rat GR

Cat.:

U1608p

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96T

CLIA Kit for Rat GR

Cat.:

U1608m

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CLIA Kit for Rat GR

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CLIA Kit for Rat GR

Cat.:

U1608r

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96T

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CLIA Kit for Rat GR

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U1608h

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Polyclonal Antibody for Rat GR

Cat.:

P1608Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat GR

Cat.:

P1608Rb-h

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Polyclonal Antibody for Rat GR

Cat.:

P1608Rb-r

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Monoclonal Antibody for Rat GR

Protein for Rat GR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Genetic complementation of a glucocorticoid receptor deficiency by expression of cloned receptor cDNA."
Miesfeld R. , Rusconi S. , Godowski P.J. , Maler B.A. , Okret S. , Wikstroem A.-C. , Gustafsson J.-A. , Yamamoto K.R.
Cell46:389-399(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hepatoma.
2.

"CAG repeat variation in the gene for rat glucocorticoid receptor: a study of allele frequencies in inbred and wild rat populations and of the steroid-binding properties of their polypeptides in vitro."
Heeley R.P. , Gill E. , van Zutphen B.
Submitted (1997-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Genetic isolation of a QTL on chromosome 18 associated with salt sensitivity in spontaneously hypertensive rats."
Pravenec M. , Zidek V. , Kostka V. , Mlejnek P. , Musilova A. , Kren V. , Jansa P. , Forejt J. , Lezin E.S. , Kurtz T.W.
Submitted (2001-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS GLY-226 AND ASP-260
strain: Brown Norway/Crl.
strain: SHR/OlaIpcv.
4.

"Cloning and sequence analysis of the rat ventral prostate glucocorticoid receptor cDNA."
Chang C. , Kokontis J. , Chang C.T. , Liao S.
Nucleic Acids Res.15:9603-9603(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-515
strain: Sprague-Dawley.
tissue: Prostate.
5.

"Metal binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis."
Severne Y. , Wieland S. , Schaffner W. , Rusconi S.
EMBO J.7:2503-2508(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ZINC-FINGER
6.

"Regulation of glucocorticoid receptor expression: evidence for transcriptional and posttranslational mechanisms."
Dong Y. , Poellinger L. , Gustafsson J.-A. , Okret S.
Mol. Endocrinol.2:1256-1264(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLUCOCORTICOID-MEDIATED DOWN-REGULATION
7.

"Creation of 'super' glucocorticoid receptors by point mutations in the steroid binding domain."
Chakraborti P.K. , Garabedian M.J. , Yamamoto K.R. , Simons S.S. Jr.
J. Biol. Chem.266:22075-22078(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-656
8.

"Zinc finger mutations that alter domain interactions in the glucocorticoid receptor."
Zandi E. , Galli I. , Doebbeling U. , Rusconi S.
J. Mol. Biol.230:124-136(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ZINC-FINGER
9.

"Active, interactive, and inactive steroid receptor mutants."
Lanz R.B. , Hug M. , Gola M. , Tallone T. , Wieland S. , Rusconi S.
Steroids59:148-152(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON MUTAGENESIS
10.

"Steroid receptor heterodimerization demonstrated in vitro and in vivo."
Liu W. , Wang J. , Sauter N.K. , Pearce D.
Proc. Natl. Acad. Sci. U.S.A.92:12480-12484(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION;HETERODIMERIZATION WITH NR3C2;MUTAGENESIS OF ASP-481
11.

"GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors."
Hong H. , Kohli K. , Garabedian M.J. , Stallcup M.R.
Mol. Cell. Biol.17:2735-2744(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA2
12.

"Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphorylation."
Rogatsky I. , Waase C.L.M. , Garabedian M.J.
J. Biol. Chem.273:14315-14321(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-171; SER-224; SER-232 AND SER-246
13.

"Receptor interacting protein RIP140 inhibits both positive and negative gene regulation by glucocorticoids."
Subramaniam N. , Treuter E. , Okret S.
J. Biol. Chem.274:18121-18127(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRIP1
14.

"Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter."
Prefontaine G.G. , Walther R. , Giffin W. , Lemieux M.E. , Pope L. , Hache R.J.G.
J. Biol. Chem.274:26713-26719(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH POU2F1 AND POU2F2;MUTAGENESIS OF CYS-500 AND LEU-501
15.

"A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP."
Mahajan M.A. , Samuels H.H.
Mol. Cell. Biol.20:5048-5063(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA6
16.

"Heterodimerization of mineralocorticoid and glucocorticoid receptors at a novel negative response element of the 5-HT1A receptor gene."
Ou X.-M. , Storring J.M. , Kushwaha N. , Albert P.R.
J. Biol. Chem.276:14299-14307(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION;HETERODIMERIZATION WITH NR3C2;MUTAGENESIS OF LEU-501
17.

"Molecular identification and characterization of A and B forms of the glucocorticoid receptor."
Yudt M.R. , Cidlowski J.A.
Mol. Endocrinol.15:1093-1103(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;MUTAGENESIS OF MET-1 AND MET-28
18.

"A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1."
Kucera T. , Waltner-Law M. , Scott D.K. , Prasad R. , Granner D.K.
J. Biol. Chem.277:26098-26102(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA1;MUTAGENESIS OF GLU-773
19.

"BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."
Hsiao P.W. , Fryer C.J. , Trotter K.W. , Wang W. , Archer T.K.
Mol. Cell. Biol.23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NCOA1; NCOA3; SMARCA4; SMARCC1; SMARCD1 AND SMARCE1;MUTAGENESIS OF ARG-488
20.

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites."
Hoffert J.D. , Pisitkun T. , Wang G. , Shen R.-F. , Knepper M.A.
Proc. Natl. Acad. Sci. U.S.A.103:7159-7164(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity."
Druker J. , Liberman A.C. , Antunica-Noguerol M. , Gerez J. , Paez-Pereda M. , Rein T. , Iniguez-Lluhi J.A. , Holsboer F. , Arzt E.
Mol. Cell. Biol.33:2116-2127(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-297; LYS-313 AND LYS-721;INTERACTION WITH UBE2I/UBC9 AND RWDD3;MUTAGENESIS OF LYS-297; LYS-313 AND LYS-721
22.

"Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA."
Luisi B.F. , Xu W.X. , Otwinowski Z. , Freedman L.P. , Yamamoto K.R. , Sigler P.B.
Nature352:497-505(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 434-525
23.

"Solution structure of the glucocorticoid receptor DNA-binding domain."
Haerd T. , Kellenbach E. , Boelens R. , Maler B.A. , Dahlman K. , Freedman L.P. , Carlstedt-Duke J. , Yamamoto K.R. , Gustafsson J.-A. , Kaptein R.
Science249:157-160(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 440-510
24.

"1H NMR studies of DNA recognition by the glucocorticoid receptor: complex of the DNA binding domain with a half-site response element."
Remerowski M.L. , Kellenbach E. , Boelens R. , van der Marel A. , van Boom J.H. , Maler B.A. , Yamamoto K.R. , Kaptein R.
Biochemistry30:11620-11624(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 440-525
25.

"Identification of the metal coordinating residues in the DNA binding domain of the glucocorticoid receptor by 113Cd-1H heteronuclear NMR spectroscopy."
Kellenbach E. , Maler B.A. , Yamamoto K.R. , Boelens R. , Kaptein R.
FEBS Lett.291:367-370(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 440-525
26.

"Refined solution structure of the glucocorticoid receptor DNA-binding domain."
Baumann H. , Paulsen K. , Kovacs H. , Berglund H. , Wright A.P.H. , Gustafsson J.-A. , Haerd T.
Biochemistry32:13463-13471(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 439-510
27.

"Heterogeneity in the polyglutamine tract of the glucocorticoid receptor from different rat strains."
Gearing K.L. , Gustafsson J.-A. , Okret S.
Nucleic Acids Res.21:2014-2014(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF POLY-GLN REGION

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