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Index > Protein center > GDF2(Gene name) > Human
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  • GDF2 (Gene name),
  • Growth/differentiation factor 2 (Protein name ),  GDF2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GDF2(BMP9);
    Protein name:
    Growth/differentiation factor 2(GDF-2);
    Alternative:
    Bone morphogenetic protein 9(BMP-9);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Could be involved in bone formation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    429
    Sequence:
    50:
    MCPGALWVAL | PLLSLLAGSL | QGKPLQSWGR | GSAGGNAHSP | LGVPGGGLPE | 
    100:
    HTFNLKMFLE | NVKVDFLRSL | NLSGVPSQDK | TRVEPPQYMI | DLYNRYTSDK | 
    150:
    STTPASNIVR | SFSMEDAISI | TATEDFPFQK | HILLFNISIP | RHEQITRAEL | 
    200:
    RLYVSCQNHV | DPSHDLKGSV | VIYDVLDGTD | AWDSATETKT | FLVSQDIQDE | 
    250:
    GWETLEVSSA | VKRWVRSDST | KSKNKLEVTV | ESHRKGCDTL | DISVPPGSRN | 
    300:
    LPFFVVFSND | HSSGTKETRL | ELREMISHEQ | ESVLKKLSKD | GSTEAGESSH | 
    350:
    EEDTDGHVAA | GSTLARRKRS | AGAGSHCQKT | SLRVNFEDIG | WDSWIIAPKE | 
    400:
    YEAYECKGGC | FFPLADDVTP | TKHAIVQTLV | HLKFPTKVGK | ACCVPTKLSP | 
    429:
    ISVLYKDDMG | VPTLKYHYEG | MSVAECGCR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    MIM:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human GDF-2
    Cat.:
    E1728h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human GDF-2
    Cat.:
    E1728m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human GDF-2
    Cat.:
    U1728h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human GDF-2
    Cat.:
    U1728m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human GDF-2
    Cat.:
    P1728Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDF-2
    Cat.:
    P1728Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GDF-2
    Monoclonal Antibody for Human GDF-2
    Protein for Human GDF-2
    Protein for Human GDF-2

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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      Celeste A.J.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Growth/differentiation factor-2, a new TGF-beta family member with bone promoting activities."
      Zimmers T.A. , Koniaris L.G. , Sitzmann J.V. , Lee S.-J.
      Submitted (1999-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 316-429
      tissue: Liver.
    6. 6.
      "Bone morphogenetic protein-9 is a circulating vascular quiescence factor."
      David L. , Mallet C. , Keramidas M. , Lamande N. , Gasc J.M. , Dupuis-Girod S. , Plauchu H. , Feige J.J. , Bailly S.
      Circ. Res.102:914-922(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth."
      Castonguay R. , Werner E.D. , Matthews R.G. , Presman E. , Mulivor A.W. , Solban N. , Sako D. , Pearsall R.S. , Underwood K.W. , Seehra J. , Kumar R. , Grinberg A.V.
      J. Biol. Chem.286:30034-30046(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ENG
    8. 8.
      "Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties."
      Mahlawat P. , Ilangovan U. , Biswas T. , Sun L.Z. , Hinck A.P.
      Biochemistry51:6328-6341(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ACVRL1
    9. 9.
      "Structural and functional insights into endoglin ligand recognition and binding."
      Alt A. , Miguel-Romero L. , Donderis J. , Aristorena M. , Blanco F.J. , Round A. , Rubio V. , Bernabeu C. , Marina A.
      PLoS ONE7:E29948-E29948(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ENG
    10. 10.
      "Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies."
      Nolan-Stevaux O. , Zhong W. , Culp S. , Shaffer K. , Hoover J. , Wickramasinghe D. , Ruefli-Brasse A.
      PLoS ONE7:E50920-E50920(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Crystal structure of BMP-9 and functional interactions with pro-region and receptors."
      Brown M.A. , Zhao Q. , Baker K.A. , Naik C. , Chen C. , Pukac L. , Singh M. , Tsareva T. , Parice Y. , Mahoney A. , Roschke V. , Sanyal I. , Choe S.
      J. Biol. Chem.280:25111-25118(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.33 ANGSTROMS) OF 320-429;DISULFIDE BONDS
    12. 12.
      "Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex."
      Townson S.A. , Martinez-Hackert E. , Greppi C. , Lowden P. , Sako D. , Liu J. , Ucran J.A. , Liharska K. , Underwood K.W. , Seehra J. , Kumar R. , Grinberg A.V.
      J. Biol. Chem.287:27313-27325(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.36 ANGSTROMS) OF 320-429 IN COMPLEX WITH ACVRL1 AND ACVR2B;DISULFIDE BONDS
    13. 13.
      "BMP9 mutations cause a vascular-anomaly syndrome with phenotypic overlap with hereditary hemorrhagic telangiectasia."
      Wooderchak-Donahue W.L. , McDonald J. , O'Fallon B. , Upton P.D. , Li W. , Roman B.L. , Young S. , Plant P. , Fulop G.T. , Langa C. , Morrell N.W. , Botella L.M. , Bernabeu C. , Stevenson D.A. , Runo J.R. , Bayrak-Toydemir P.
      Am. J. Hum. Genet.93:530-537(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HHT5 LEU-68; LEU-85 AND TRP-333;PROTEOLYTIC PROCESSING
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