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Index > Protein center > GDF9(Gene name) > Human
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  • GDF9 (Gene name),
  • Growth/differentiation factor 9 (Protein name ),  GDF9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    GDF9;
    Protein name:
    Growth/differentiation factor 9(GDF-9);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
    Function:
    Required for ovarian folliculogenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    454
    Sequence:
    50:
    MARPNKFLLW | FCCFAWLCFP | ISLGSQASGG | EAQIAASAEL | ESGAMPWSLL | 
    100:
    QHIDERDRAG | LLPALFKVLS | VGRGGSPRLQ | PDSRALHYMK | KLYKTYATKE | 
    150:
    GIPKSNRSHL | YNTVRLFTPC | TRHKQAPGDQ | VTGILPSVEL | LFNLDRITTV | 
    200:
    EHLLKSVLLY | NINNSVSFSS | AVKCVCNLMI | KEPKSSSRTL | GRAPYSFTFN | 
    250:
    SQFEFGKKHK | WIQIDVTSLL | QPLVASNKRS | IHMSINFTCM | KDQLEHPSAQ | 
    300:
    NGLFNMTLVS | PSLILYLNDT | SAQAYHSWYS | LHYKRRPSQG | PDQERSLSAY | 
    350:
    PVGEEAAEDG | RSSHHRHRRG | QETVSSELKK | PLGPASFNLS | EYFRQFLLPQ | 
    400:
    NECELHDFRL | SFSQLKWDNW | IVAPHRYNPR | YCKGDCPRAV | GHRYGSPVHT | 
    450:
    MVQNIIYEKL | DSSVPRPSCV | PAKYSPLSVL | TIEPDGSIAY | KEYEDMIATK | 
    454:
    CTCR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    UniGene:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human GDF-9
    Cat.:
    E0427h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GDF-9
    Cat.:
    E0427b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GDF-9
    Cat.:
    E0427m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDF-9
    Cat.:
    U0427h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GDF-9
    Cat.:
    U0427b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDF-9
    Cat.:
    U0427m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GDF-9
    Cat.:
    P0427Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDF-9
    Polyclonal Antibody for Human GDF-9
    Cat.:
    P0427Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GDF-9
    Monoclonal Antibody for Human GDF-9
    Monoclonal Antibody for Human GDF-9
    Protein for Human GDF-9
    Protein for Human GDF-9
    Protein for Human GDF-9

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    2. 3.
      "Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis."
      Aaltonen J. , Laitinen M.P. , Vuojolainen K. , Jaatinen R. , Horelli-Kuitunen N. , Seppae L. , Louhio H. , Tuuri T. , Sjoeberg J. , Buetzow R. , Hovatta O. , Dale L. , Ritvos O.
      J. Clin. Endocrinol. Metab.84:2744-2750(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    3. 4.
      "Growth differentiation factor-9 inhibits 3'5'-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells."
      Yamamoto N. , Christenson L.K. , McAllister J.M. , Strauss J.F. III
      J. Clin. Endocrinol. Metab.87:2849-2856(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REGULATOR OF PROGESTERONE RELEASE;TISSUE SPECIFICITY
    4. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    5. 6.
      "Phosphorylation of bone morphogenetic protein-15 and growth and differentiation factor-9 plays a critical role in determining agonistic or antagonistic functions."
      McMahon H.E. , Sharma S. , Shimasaki S.
      Endocrinology149:812-817(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    6. 7.
      "Effects of growth differentiation factor 9 on cell cycle regulators and ERK42/44 in human granulosa cell proliferation."
      Huang Q. , Cheung A.P. , Zhang Y. , Huang H.F. , Auersperg N. , Leung P.C.
      Am. J. Physiol.296:E1344-E1353(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GRANULOSA CELLS PROLIFERATION
    7. 8.
      "Golgi apparatus casein kinase phosphorylates bioactive Ser-6 of bone morphogenetic protein 15 and growth and differentiation factor 9."
      Tibaldi E. , Arrigoni G. , Martinez H.M. , Inagaki K. , Shimasaki S. , Pinna L.A.
      FEBS Lett.584:801-805(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-325 BY CK;IDENTIFICATION BY MASS SPECTROMETRY
    8. 9.
      "Growth differentiation factor 9 reverses activin A suppression of steroidogenic acute regulatory protein expression and progesterone production in human granulosa-lutein cells."
      Shi F.T. , Cheung A.P. , Klausen C. , Huang H.F. , Leung P.C.
      J. Clin. Endocrinol. Metab.95:E172-E180(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REGULATOR OF STAR EXPRESSION AND PROGESTERONE RELEASE
    9. 10.
      "Growth differentiating factor 9 (GDF9) and bone morphogenetic protein 15 both activate development of human primordial follicles in vitro, with seemingly more beneficial effects of GDF9."
      Kedem A. , Fisch B. , Garor R. , Ben-Zaken A. , Gizunterman T. , Felz C. , Ben-Haroush A. , Kravarusic D. , Abir R.
      J. Clin. Endocrinol. Metab.96:E1246-E1254(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PRIMORDIAL FOLLICLE DEVELOPMENT
    10. 11.
      "Growth differentiation factor 9 (GDF9) suppresses follistatin and follistatin-like 3 production in human granulosa-lutein cells."
      Shi F.T. , Cheung A.P. , Huang H.F. , Leung P.C.
      PLoS ONE6:E22866-E22866(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 12.
      "The ratio of growth differentiation factor 9: bone morphogenetic protein 15 mRNA expression is tightly co-regulated and differs between species over a wide range of ovulation rates."
      Crawford J.L. , McNatty K.P.
      Mol. Cell. Endocrinol.348:339-343(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPECIES-SPECIFIC OVULATION RATE DETERMINATION
    12. 13.
      "Mutational screening of the coding region of growth differentiation factor 9 gene in Indian women with ovarian failure."
      Dixit H. , Rao L.K. , Padmalatha V. , Kanakavalli M. , Deenadayal M. , Gupta N. , Chakravarty B. , Singh L.
      Menopause12:749-754(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-67 AND MET-216
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-186
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-103; ILE-121; LEU-374 AND CYS-454;POSSIBLE INVOLVEMENT IN OVARIAN DISORDERS
    15. 16.
      "Growth differentiating factor-9 mutations may be associated with premature ovarian failure."
      Kovanci E. , Rohozinski J. , Simpson J.L. , Heard M.J. , Bishop C.E. , Carson S.A.
      Fertil. Steril.87:143-146(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-103;POSSIBLE INVOLVEMENT IN PREMATURE OVARIAN FAILURE
    16. 17.
      "Analyses of GDF9 mutation in 100 Chinese women with premature ovarian failure."
      Zhao H. , Qin Y. , Kovanci E. , Simpson J.L. , Chen Z.J. , Rajkovic A.
      Fertil. Steril.88:1474-1476(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-146; ALA-238 AND THR-428
    17. 18.
      "Analyses of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) mutation in Chinese women with premature ovarian failure."
      Wang B. , Wen Q. , Ni F. , Zhou S. , Wang J. , Cao Y. , Ma X.
      Clin. Endocrinol. (Oxf.)72:135-136(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-57
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