GGT1 ELISA Kit for Human(Homo sapiens) | EIAab.comGGT1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GGT1(Gene name) > Human

GGT1 (Gene name),

Gamma-glutamyltranspeptidase 1 (Protein name ), GGT1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GGT1(GGT);

Protein name:

Gamma-glutamyltranspeptidase 1(GGT 1);

Alternative:

3.4.19.13;Glutathione hydrolase 1);Gamma-glutamyltransferase 1;3.4.19.14;Leukotriene-C4 hydrolase);

CD:

CD224;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

Function:

Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.

Subcellular Location:

Membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

569

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

569:

AGGWAAASDS | RKGGEPAGY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P19440

Pfam:

PF01019

String:

P19440

UniGene:

Hs.595809

STRING:

9606.ENSP00000248923

KEGG:

hsa:2678

MIM:

231950

Uniprot:

P19440

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ELISA Kit for Human GGT 1

Cat.:

E1375h

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Packing:

96T

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ELISA Kit for Human GGT 1

Cat.:

E1375m

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96T

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ELISA Kit for Human GGT 1

Cat.:

E1375r

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96T

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ELISA Kit for Human GGT 1

Cat.:

E1375p

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MSDS:

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Packing:

96T

CLIA Kit for Human GGT 1

Cat.:

U1375r

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96T

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CLIA Kit for Human GGT 1

Cat.:

U1375p

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MSDS:

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Packing:

96T

CLIA Kit for Human GGT 1

Cat.:

U1375m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human GGT 1

Cat.:

U1375h

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96T

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Polyclonal Antibody for Human GGT 1

Cat.:

P1375Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GGT 1

Cat.:

P1375Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human GGT 1

Cat.:

P1375Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human GGT 1

Monoclonal Antibody for Human GGT 1

Protein for Human GGT 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase."
Rajpert-De Meyts E. , Heisterkamp N. , Groffen J.
Proc. Natl. Acad. Sci. U.S.A.85:8840-8844(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-272
tissue: Placenta.
2.

"The primary structure of human gamma-glutamyl transpeptidase."
Sakamuro D. , Yamazoe M. , Matsuda Y. , Kangawa K. , Taniguchi N. , Matsuo H. , Yoshikawa H. , Ogasawara N.
Gene73:1-9(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 30-58 AND 381-408;VARIANT ALA-272
tissue: Kidney.
tissue: Liver.
3.

"Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis."
Pitot H.C. , Goodspeed D.C. , Dunn T.J. , Hendrich S. , Maronpot R.R. , Moran S.
Toxicol. Appl. Pharmacol.97:23-34(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-272
4.

"Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat."
Goodspeed D.C. , Dunn T.J. , Miller C.D. , Pitot H.C.
Gene76:1-9(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-272
tissue: Hepatoblastoma.
5.

"An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues."
Pawlak A. , Cohen E.H. , Octave J.-N. , Schweickhardt R. , Wu S.-J. , Bulle F. , Chikhi N. , Baik J.-H. , Siegrist S. , Guellaen G.
J. Biol. Chem.265:3256-3262(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ALA-272
tissue: Liver.
6.

"Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues."
Courtay C. , Oster T. , Michelet F. , Visvikis A. , Diederich M. , Wellman M. , Siest G.
Biochem. Pharmacol.43:2527-2533(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-272
tissue: Pancreas.
7.

"Human lung expresses unique gamma-glutamyl transpeptidase transcripts."
Wetmore L.A. , Gerard C. , Drazen J.M.
Proc. Natl. Acad. Sci. U.S.A.90:7461-7465(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);LACK OF FUNCTION OF ISOFORM 3
tissue: Lung.
8.

"A genome annotation-driven approach to cloning the human ORFeome."
Collins J.E. , Wright C.L. , Edwards C.A. , Davis M.P. , Grinham J.A. , Cole C.G. , Goward M.E. , Aguado B. , Mallya M. , Mokrab Y. , Huckle E.J. , Beare D.M. , Dunham I.
Genome Biol.5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

"The DNA sequence of human chromosome 22."
Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue: Lung.
11.

"Renal gamma-glutamyl transpeptidases: structural and immunological studies."
Tate S.S. , Khadse V. , Wellner D.
Arch. Biochem. Biophys.262:397-408(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-48 AND 381-403
tissue: Kidney.
12.

"Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species."
Chikhi N. , Holic N. , Guellaen G. , Laperche Y.
Comp. Biochem. Physiol.122B:367-380(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;ALTERNATIVE PROMOTER USAGE
13.

"Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit."
Tate S.S. , Ross M.E.
J. Biol. Chem.252:6042-6045(1977) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;SIALIC ACID CONTENT
tissue: Kidney.
14.

"In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase."
Tate S.S. , Galbraith R.A.
Biochem. Biophys. Res. Commun.154:1167-1173(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
15.

"Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis."
Ikeda Y. , Fujii J. , Taniguchi N.
J. Biol. Chem.268:3980-3985(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;AUTOCATALYTIC CLEAVAGE;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-100; GLU-102; ARG-107; GLU-108; ARG-112; ARG-139; ARG-147 AND ARG-150
16.

"Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit."
Ikeda Y. , Fujii J. , Taniguchi N. , Meister A.
J. Biol. Chem.270:12471-12475(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF ASP-422; ASP-423 AND CYS-454
17.

"Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase."
Ikeda Y. , Fujii J. , Anderson M.E. , Taniguchi N. , Meister A.
J. Biol. Chem.270:22223-22228(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF SER-385; SER-413; SER-425; SER-451 AND SER-452
18.

"Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase."
Ikeda Y. , Fujii J. , Taniguchi N.
J. Biochem.119:1166-1170(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF HIS-383 AND HIS-505
19.

"A proteomic analysis of human bile."
Kristiansen T.Z. , Bunkenborg J. , Gronborg M. , Molina H. , Thuluvath P.J. , Argani P. , Goggins M.G. , Maitra A. , Pandey A.
Mol. Cell. Proteomics3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-511
tissue: Bile.
20.

"Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase."
Castonguay R. , Halim D. , Morin M. , Furtos A. , Lherbet C. , Bonneil E. , Thibault P. , Keillor J.W.
Biochemistry46:12253-12262(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ACTIVE SITE;GLYCOSYLATION AT ASN-120; ASN-266; ASN-344 AND ASN-511;IDENTIFICATION BY MASS SPECTROMETRY
21.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-120; ASN-230 AND ASN-511
tissue: Liver.
22.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-120
tissue: Leukemic T-cell.
23.

"Analysis of site-specific glycosylation of renal and hepatic gamma-glutamyl transpeptidase from normal human tissue."
West M.B. , Segu Z.M. , Feasley C.L. , Kang P. , Klouckova I. , Li C. , Novotny M.V. , West C.M. , Mechref Y. , Hanigan M.H.
J. Biol. Chem.285:29511-29524(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;GLYCOSYLATION AT ASN-95; ASN-120; ASN-230; ASN-266; ASN-297; ASN-344 AND ASN-511
24.

"Human GGT2 does not autocleave into a functional enzyme: a cautionary tale for interpretation of microarray data on redox signaling."
West M.B. , Wickham S. , Parks E.E. , Sherry D.M. , Hanigan M.H.
Antioxid. Redox Signal.19:1877-1888(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;AUTOCATALYTIC CLEAVAGE;ENZYME REGULATION;SUBCELLULAR LOCATION;GLYCOSYLATION;MUTAGENESIS OF CYS-192 AND GLU-193
25.

"Novel insights into eukaryotic gamma-glutamyl transpeptidase 1 from the crystal structure of the glutamate-bound human enzyme."
West M.B. , Chen Y. , Wickham S. , Heroux A. , Cahill K. , Hanigan M.H. , Mooers B.H.
J. Biol. Chem.288:31902-31913(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) IN COMPLEX WITH GLUTAMATE AND CHLORIDE IONS;FUNCTION;CATALYTIC ACTIVITY;AUTOCATALYTIC CLEAVAGE;SUBUNIT;MUTAGENESIS OF GLN-545;DISULFIDE BONDS;GLYCOSYLATION AT ASN-95; ASN-120; ASN-230; ASN-266; ASN-344 AND ASN-511

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