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Index > Protein center > GLS(Gene name) > Human
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  • GLS (Gene name),
  • Glutaminase kidney isoform, mitochondrial (Protein name ),  GLSK_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GLS(GLS1;KIAA0838);
    Protein name:
    Glutaminase kidney isoform, mitochondrial(GLS);
    Alternative:
    K-glutaminase;L-glutamine amidohydrolase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    669
    Sequence:
    50:
    MMRLRGSGML | RDLLLRSPAG | VSATLRRAQP | LVTLCRRPRG | GGRPAAGPAA | 
    100:
    AARLHPWWGG | GGWPAEPLAR | GLSSSPSEIL | QELGKGSTHP | QPGVSPPAAP | 
    150:
    AAPGPKDGPG | ETDAFGNSEG | KELVASGENK | IKQGLLPSLE | DLLFYTIAEG | 
    200:
    QEKIPVHKFI | TALKSTGLRT | SDPRLKECMD | MLRLTLQTTS | DGVMLDKDLF | 
    250:
    KKCVQSNIVL | LTQAFRRKFV | IPDFMSFTSH | IDELYESAKK | QSGGKVADYI | 
    300:
    PQLAKFSPDL | WGVSVCTVDG | QRHSTGDTKV | PFCLQSCVKP | LKYAIAVNDL | 
    350:
    GTEYVHRYVG | KEPSGLRFNK | LFLNEDDKPH | NPMVNAGAIV | VTSLIKQGVN | 
    400:
    NAEKFDYVMQ | FLNKMAGNEY | VGFSNATFQS | ERESGDRNFA | IGYYLKEKKC | 
    450:
    FPEGTDMVGI | LDFYFQLCSI | EVTCESASVM | AATLANGGFC | PITGERVLSP | 
    500:
    EAVRNTLSLM | HSCGMYDFSG | QFAFHVGLPA | KSGVAGGILL | VVPNVMGMMC | 
    550:
    WSPPLDKMGN | SVKGIHFCHD | LVSLCNFHNY | DNLRHFAKKL | DPRREGGDQR | 
    600:
    VKSVINLLFA | AYTGDVSALR | RFALSAMDME | QRDYDSRTAL | HVAAAEGHVE | 
    650:
    VVKFLLEACK | VNPFPKDRWN | NTPMDEALHF | GHHDVFKILQ | EYQVQYTPQG | 
    669:
    DSDNGKENQT | VHKNLDGLL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human GLS
    Cat.:
    E15055h
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    ELISA Kit for Human GLS
    MSDS:
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    ELISA Kit for Human GLS
    MSDS:
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    CLIA Kit for Human GLS
    MSDS:
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    CLIA Kit for Human GLS
    MSDS:
    Please sign in first.
    CLIA Kit for Human GLS
    Cat.:
    U15055h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GLS
    Polyclonal Antibody for Human GLS
    Polyclonal Antibody for Human GLS
    Monoclonal Antibody for Human GLS
    Monoclonal Antibody for Human GLS
    Monoclonal Antibody for Human GLS
    Protein for Human GLS
    Protein for Human GLS
    Protein for Human GLS

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing."
      Elgadi K.M. , Meguid R.A. , Qian M. , Souba W.W. , Abcouwer S.F.
      Physiol. Genomics1:51-62(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY;ALTERNATIVE SPLICING
      tissue: Placenta.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Identification and expression of human renal and hepatic glutaminase isoforms."
      Chavez R.A. , Wang C. , Cong R. , Hawkinson J.E. , Forsayeth J.R.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Isolation, characterization and expression of a human brain mitochondrial glutaminase cDNA."
      Holcomb T. , Taylor L. , Trohkimoinen J. , Curthoys N.P.
      Brain Res. Mol. Brain Res.76:56-63(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Adenoma and carcinoma cell lines derived from colorectal tumours express different isoforms of glutaminase."
      Turner A. , McGivan J.D.
      Submitted (2000-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 225-466
      tissue: Colon carcinoma.
    7. 7.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    8. 8.
      "Brain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levels."
      Buschdorf J.P. , Li Chew L. , Zhang B. , Cao Q. , Liang F.Y. , Liou Y.C. , Zhou Y.T. , Low B.C.
      J. Cell Sci.119:3337-3350(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATCAY;SUBCELLULAR LOCATION
    9. 9.
      "Relative expression of mRNAs coding for glutaminase isoforms in CNS tissues and CNS tumors."
      Szeliga M. , Matyja E. , Obara M. , Grajkowska W. , Czernicki T. , Albrecht J.
      Neurochem. Res.33:808-813(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY (ISOFORM 1 AND ISOFORM 3)
    10. 10.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION
    11. 11.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-311;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Mitochondrial localization and structure-based phosphate activation mechanism of glutaminase C with implications for cancer metabolism."
      Cassago A. , Ferreira A.P. , Ferreira I.M. , Fornezari C. , Gomes E.R. , Greene K.S. , Pereira H.M. , Garratt R.C. , Dias S.M. , Ambrosio A.L.
      Proc. Natl. Acad. Sci. U.S.A.109:1092-1097(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      "Full-length human glutaminase in complex with an allosteric inhibitor."
      DeLaBarre B. , Gross S. , Fang C. , Gao Y. , Jha A. , Jiang F. , Song J.J. , Wei W. , Hurov J.B.
      Biochemistry50:10764-10770(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 71-550 (ISOFORM 3) IN COMPLEXES WITH GLUTAMATE AND SYNTHETIC INHIBITOR BPTES;PROTEIN SEQUENCE OF N-TERMINUS;CATALYTIC ACTIVITY;MUTAGENESIS OF PHE-318; PHE-322 AND TYR-394;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT
    15. 15.
      "Human glutaminase in complex with L-glutamate."
      Structural genomics consortium (SGC)
      Submitted (2011-07) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 221-533 IN COMPLEX WITH GLUTAMATE
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