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Index > Protein center > GNRHR(Gene name) > Human
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  • GNRHR (Gene name),
  • Gonadotropin-releasing hormone receptor (Protein name ),  GNRHR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GNRHR(GRHR);
    Protein name:
    Gonadotropin-releasing hormone receptor(GnRH receptor;GnRH-R);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    328
    Sequence:
    50:
    MANSASPEQN | QNHCSAINNS | IPLMQGNLPT | LTLSGKIRVT | VTFFLFLLSA | 
    100:
    TFNASFLLKL | QKWTQKKEKG | KKLSRMKLLL | KHLTLANLLE | TLIVMPLDGM | 
    150:
    WNITVQWYAG | ELLCKVLSYL | KLFSMYAPAF | MMVVISLDRS | LAITRPLALK | 
    200:
    SNSKVGQSMV | GLAWILSSVF | AGPQLYIFRM | IHLADSSGQT | KVFSQCVTHC | 
    250:
    SFSQWWHQAF | YNFFTFSCLF | IIPLFIMLIC | NAKIIFTLTR | VLHQDPHELQ | 
    300:
    LNQSKNNIPR | ARLKTLKMTV | AFATSFTVCW | TPYYVLGIWY | WFDPEMLNRL | 
    328:
    SDPVNHFFFL | FAFLNPCFDP | LIYGYFSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human GnRH receptor
    Cat.:
    E1672b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GnRH receptor
    Cat.:
    U1672b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GnRH receptor
    Polyclonal Antibody for Human GnRH receptor
    Cat.:
    P1672Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GnRH receptor
    Cat.:
    P1672Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GnRH receptor
    Polyclonal Antibody for Human GnRH receptor
    Polyclonal Antibody for Human GnRH receptor
    Cat.:
    P1672Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GnRH receptor
    Monoclonal Antibody for Human GnRH receptor
    Monoclonal Antibody for Human GnRH receptor
    Monoclonal Antibody for Human GnRH receptor
    Monoclonal Antibody for Human GnRH receptor
    Monoclonal Antibody for Human GnRH receptor
    Protein for Human GnRH receptor
    Protein for Human GnRH receptor
    Protein for Human GnRH receptor
    Protein for Human GnRH receptor
    Protein for Human GnRH receptor
    Protein for Human GnRH receptor

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    Linearity
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    References
    1. 1.
      "Cloning, sequencing, and expression of human gonadotropin releasing hormone (GnRH) receptor."
      Kakar S.S. , Musgrove L.C. , Devor D.C. , Sellers J.C. , Neill J.D.
      Biochem. Biophys. Res. Commun.189:289-295(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Pituitary.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Pituitary.
    3. 3.
      "The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary."
      Kakar S.S. , Grizzle W.E. , Neill J.D.
      Mol. Cell. Endocrinol.106:145-149(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Molecular structure of the human gonadotropin-releasing hormone receptor gene."
      Kakar S.S.
      Eur. J. Endocrinol.137:183-192(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "Inhibition of gonadotropin-releasing hormone receptor signaling by expression of a splice variant of the human receptor."
      Grosse R. , Schoneberg T. , Schultz G. , Gudermann T.
      Mol. Endocrinol.11:1305-1318(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Pituitary.
    6. 6.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "Tissue-specific pattern of variant transcripts of the human gonadotropin-releasing hormone receptor gene."
      Kottler M.L. , Bergametti F. , Carre M.C. , Morice S. , Decoret E. , Lagarde J.P. , Starzec A. , Counis R.
      Eur. J. Endocrinol.140:561-569(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 247-328 (ISOFORM 1)
    9. 9.
      "A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor."
      de Roux N. , Young J. , Misrahi M. , Genet R. , Chanson P. , Schaison G. , Milgrom E.
      N. Engl. J. Med.337:1597-1602(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 ARG-106 AND GLN-262
    10. 10.
      "Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism."
      Layman L.C. , Cohen D.P. , Jin M. , Xie J. , Li Z. , Reindollar R.H. , Bolbolan S. , Bick D.P. , Sherins R.R. , Duck L.W. , Musgrove L.C. , Sellers J.C. , Neill J.D.
      Nat. Genet.18:14-15(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 GLN-262 AND CYS-284;CHARACTERIZATION OF VARIANTS HH7 GLN-262 AND CYS-284
    11. 11.
      "The same molecular defects of the gonadotropin-releasing hormone receptor determine a variable degree of hypogonadism in affected kindred."
      de Roux N. , Young J. , Brailly-Tabard S. , Misrahi M. , Milgrom E. , Schaison G.
      J. Clin. Endocrinol. Metab.84:567-572(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 ARG-106; ARG-217 AND GLN-262;CHARACTERIZATION OF VARIANTS HH7 ARG-106; ARG-217 AND GLN-262
    12. 12.
      "Resistance of hypogonadic patients with mutated GnRH receptor genes to pulsatile GnRH administration."
      Caron P. , Chauvin S. , Christin-Maitre S. , Bennet A. , Lahlou N. , Counis R. , Bouchard P. , Kottler M.-L.
      J. Clin. Endocrinol. Metab.84:990-996(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 ASP-129 AND GLN-262;CHARACTERIZATION OF VARIANT HH7 ASP-129
    13. 13.
      "Complete hypogonadotropic hypogonadism associated with a novel inactivating mutation of the gonadotropin-releasing hormone receptor."
      Pralong F.P. , Gomez F. , Castillo E. , Cotecchia S. , Abuin L. , Aubert M.L. , Portmann L. , Gaillard R.C.
      J. Clin. Endocrinol. Metab.84:3811-3816(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH7 ARG-168;CHARACTERIZATION OF VARIANT HH7 ARG-168
    14. 14.
      "The fertile eunuch variant of idiopathic hypogonadotropic hypogonadism: spontaneous reversal associated with a homozygous mutation in the gonadotropin-releasing hormone receptor."
      Pitteloud N. , Boepple P.A. , DeCruz S. , Valkenburgh S.B. , Crowley W.F. Jr. , Hayes F.J.
      J. Clin. Endocrinol. Metab.86:2470-2475(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FEUNS ARG-106
    15. 15.
      "A novel homozygous mutation in the second transmembrane domain of the gonadotrophin releasing hormone receptor gene."
      Soederlund D. , Canto P. , de la Chesnaye E. , Ulloa-Aguirre A. , Mendez J.P.
      Clin. Endocrinol. (Oxf.)54:493-498(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH7 LYS-90
    16. 16.
      "Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction."
      Costa E.M.F. , Bedecarrats G.Y. , Mendonca B.B. , Arnhold I.J.P. , Kaiser U.B. , Latronico A.C.
      J. Clin. Endocrinol. Metab.86:2680-2686(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 LYS-10; ARG-106 AND HIS-139;CHARACTERIZATION OF VARIANTS HH7 LYS-10; ARG-106 AND HIS-139
    17. 17.
      "Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site."
      Maya-Nunez G. , Janovick J.A. , Ulloa-Aguirre A. , Soederlund D. , Conn P.M. , Mendez J.P.
      J. Clin. Endocrinol. Metab.87:2144-2149(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT HH7 LYS-90
    18. 18.
      "Mutation Ala(171)Thr stabilizes the gonadotropin-releasing hormone receptor in its inactive conformation, causing familial hypogonadotropic hypogonadism."
      Karges B. , Karges W. , Mine M. , Ludwig L. , Kuehne R. , Milgrom E. , de Roux N.
      J. Clin. Endocrinol. Metab.88:1873-1879(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HH7 THR-171;CHARACTERIZATION OF VARIANT HH7 THR-171
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HH7 VAL-83; ARG-106 AND GLN-262
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