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Index > Protein center > GPC1(Gene name) > Human
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  • GPC1 (Gene name),
  • Glypican-1 (Protein name ),  GPC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GPC1;
    Protein name:
    Glypican-1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cell surface proteoglycan that bears heparan sulfate.
    Subcellular Location:
    Secreted glypican-1 Secreted extracellular space
    Protein Attributes:
    Sequence length:
    558
    Sequence:
    50:
    MELRARGWWL | LCAAAALVAC | ARGDPASKSR | SCGEVRQIYG | AKGFSLSDVP | 
    100:
    QAEISGEHLR | ICPQGYTCCT | SEMEENLANR | SHAELETALR | DSSRVLQAML | 
    150:
    ATQLRSFDDH | FQHLLNDSER | TLQATFPGAF | GELYTQNARA | FRDLYSELRL | 
    200:
    YYRGANLHLE | ETLAEFWARL | LERLFKQLHP | QLLLPDDYLD | CLGKQAEALR | 
    250:
    PFGEAPRELR | LRATRAFVAA | RSFVQGLGVA | SDVVRKVAQV | PLGPECSRAV | 
    300:
    MKLVYCAHCL | GVPGARPCPD | YCRNVLKGCL | ANQADLDAEW | RNLLDSMVLI | 
    350:
    TDKFWGTSGV | ESVIGSVHTW | LAEAINALQD | NRDTLTAKVI | QGCGNPKVNP | 
    400:
    QGPGPEEKRR | RGKLAPRERP | PSGTLEKLVS | EAKAQLRDVQ | DFWISLPGTL | 
    450:
    CSEKMALSTA | SDDRCWNGMA | RGRYLPEVMG | DGLANQINNP | EVEVDITKPD | 
    500:
    MTIRQQIMQL | KIMTNRLRSA | YNGNDVDFQD | ASDDGSGSGS | GDGCLDDLCS | 
    550:
    RKVSRKSSSS | RTPLTHALPG | LSEQEGQKTS | AASCPQPPTF | LLPLLLFLAL | 
    558:
    TVARPRWR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glypican-1
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    E9038h
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    ELISA Kit for Human Glypican-1
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    ELISA Kit for Human Glypican-1
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    E9038m
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    ELISA Kit for Human Glypican-1
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    E9038r
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    96T
    ELISA Kit for Human Glypican-1
    Cat.:
    E9038b
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    Packing:
    96T
    CLIA Kit for Human Glypican-1
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    U9038r
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    CLIA Kit for Human Glypican-1
    Cat.:
    U9038b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Glypican-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Glypican-1
    Cat.:
    U9038m
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    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Glypican-1
    Cat.:
    U9038h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Glypican-1
    Polyclonal Antibody for Human Glypican-1
    Cat.:
    P9038Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glypican-1
    Polyclonal Antibody for Human Glypican-1
    Polyclonal Antibody for Human Glypican-1
    Cat.:
    P9038Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Glypican-1
    Monoclonal Antibody for Human Glypican-1
    Monoclonal Antibody for Human Glypican-1
    Monoclonal Antibody for Human Glypican-1
    Monoclonal Antibody for Human Glypican-1
    Protein for Human Glypican-1
    Protein for Human Glypican-1
    Protein for Human Glypican-1
    Protein for Human Glypican-1
    Protein for Human Glypican-1

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    References
    1. 1.
      "Molecular cloning of a phosphatidylinositol-anchored membrane heparan sulfate proteoglycan from human lung fibroblasts."
      David G. , Lories V. , Decock B. , Marynen P. , Cassiman J.-J. , van den Berghe H.
      J. Cell Biol.111:3165-3176(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 24-53; 100-118 AND 298-317;GPI-ANCHOR AT SER-530;GLYCOSYLATION AT ASN-116;VARIANT GLY-500
      tissue: Lung fibroblast.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
      tissue: Tongue.
    3. 3.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLY-500
      tissue: Salivary gland.
    6. 6.
      "Prion, amyloid beta-derived Cu(II) ions, or free Zn(II) ions support S-nitroso-dependent autocleavage of glypican-1 heparan sulfate."
      Mani K. , Cheng F. , Havsmark B. , Jonsson M. , Belting M. , Fransson L.A.
      J. Biol. Chem.278:38956-38965(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COPPER-BINDING;S-NITROSYLATION;GLYCOSYLATION
    7. 7.
      "Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease."
      Watanabe N. , Araki W. , Chui D.H. , Makifuchi T. , Ihara Y. , Tabira T.
      FASEB J.18:1013-1015(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;POSSIBLE ASSOCIATION WITH ALZHEIMER DISEASE
    8. 8.
      "Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts."
      Mani K. , Cheng F. , Fransson L.A.
      Glycobiology16:711-718(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION;ASSOCIATION WITH NIEMANN-PICK TYPE C1 DISEASE
    9. 9.
      "Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes."
      Mani K. , Cheng F. , Fransson L.A.
      Glycobiology16:1251-1261(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;S-NITROSYLATION;GLYCOSYLATION
    10. 10.
      "Chemical and thermal unfolding of glypican-1: protective effect of heparan sulfate against heat-induced irreversible aggregation."
      Svensson G. , Linse S. , Mani K.
      Biochemistry48:9994-10004(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;ABSENCE OF GLYCOSYLATION AT SER-55
    11. 11.
      "S-Nitrosylation of secreted recombinant human glypican-1."
      Svensson G. , Mani K.
      Glycoconj. J.26:1247-1257(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION;SUBCELLULAR LOCATION;GLYCOSYLATION
    12. 12.
      "Glypican-1 mediates both prion protein lipid raft association and disease isoform formation."
      Taylor D.R. , Whitehouse I.J. , Hooper N.M.
      PLoS Pathog.5:E1000666-E1000666(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "The structural role of N-linked glycans on human glypican-1."
      Svensson G. , Hyrenius Wittsten A. , Linse S. , Mani K.
      Biochemistry50:9377-9387(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-79 AND ASN-116;MUTAGENESIS OF ASN-79 AND ASN-116
    14. 14.
      "Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation."
      Cheng F. , Cappai R. , Ciccotosto G.D. , Svensson G. , Multhaup G. , Fransson L.A. , Mani K.
      J. Biol. Chem.286:27559-27572(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION;GLYCOSYLATION;FUNCTION
    15. 15.
      "Crystal structure of N-glycosylated human glypican-1 core protein: Structure of two loops evolutionarily conserved in vertebrate glypican-1."
      Svensson G. , Awad W. , Hakansson M. , Mani K. , Logan D.T.
      J. Biol. Chem.287:14040-14051(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS);DISULFIDE BONDS;LACK OF GLYCOSYLATION AT SER-55;GLYCOSYLATION AT ASN-79 AND ASN-116
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-337
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