GZMA ELISA Kit for Human(Homo sapiens) | EIAab.comGZMA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GZMA(Gene name) > Human

GZMA (Gene name),

Granzyme A (Protein name ), GRAA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GZMA(CTLA3;HFSP);

Protein name:

Granzyme A;

Alternative:

Cytotoxic T-lymphocyte proteinase 1;CTL tryptase;Granzyme-1;Fragmentin-1;Hanukkah factor(H factor;HF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interacts with APEX1.

Function:

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.

Subcellular Location:

Isoform alpha Secreted Cytoplasmic granule

Protein Attributes:

Sequence length:

262

Sequence:

50:

100:

150:

200:

250:

262:

LNWIIMTIKG | AV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000274306

Pfam:

PF00089

MIM:

140050

KEGG:

hsa:3001

SMR:

P12544

String:

P12544

UniGene:

Hs.90708

Uniprot:

P12544

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ELISA Kit for Human Granzyme A

Cat.:

E0599h

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96T

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ELISA Kit for Human Granzyme A

Cat.:

E0599b

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96T

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ELISA Kit for Human Granzyme A

Cat.:

E0599m

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Granzyme A

Cat.:

U0599h

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Packing:

96T

CLIA Kit for Human Granzyme A

Cat.:

U0599b

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Packing:

96T

CLIA Kit for Human Granzyme A

Cat.:

U0599m

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Packing:

96T

Polyclonal Antibody for Human Granzyme A

Cat.:

P0599Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Granzyme A

Cat.:

P0599Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Granzyme A

Protein for Human Granzyme A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine protease."
Gershenfeld H.K. , Hershberger R.J. , Shows T.B. , Weissman I.L.
Proc. Natl. Acad. Sci. U.S.A.85:1184-1188(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA);VARIANT THR-121
tissue: T-cell.
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT THR-121
3.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA);VARIANT THR-121
tissue: Blood.
5.

"Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A."
Ruike Y. , Katsuma S. , Hirasawa A. , Tsujimoto G.
J. Hum. Genet.52:172-178(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72;NUCLEOTIDE SEQUENCE [MRNA] OF 1-34 (ISOFORM BETA);ALTERNATIVE PROMOTER USAGE;INDUCTION
6.

"The upstream region of the human granzyme A locus contains both positive and negative transcriptional regulatory elements."
Goralski T.J. , Krensky A.M.
Submitted (1995-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23
7.

"Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity."
Poe M. , Bennett C.D. , Biddison W.E. , Blake J.T. , Norton G.P. , Rodkey J.A. , Sigal N.H. , Turner R.V. , Wu J.K. , Zweerink H.J.
J. Biol. Chem.263:13215-13222(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-53
8.

"Characterization of three serine esterases isolated from human IL-2 activated killer cells."
Hameed A. , Lowrey D.M. , Lichtenheld M. , Podack E.R.
J. Immunol.141:3142-3147(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-40;CHARACTERIZATION
9.

"Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes."
Kraehenbuhl O. , Rey C. , Jenne D.E. , Lanzavecchia A. , Groscurth P. , Carrel S. , Tschopp J.
J. Immunol.141:3471-3477(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-39;CHARACTERIZATION
10.

"Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks."
Beresford P.J. , Zhang D. , Oh D.Y. , Fan Z. , Greer E.L. , Russo M.L. , Jaju M. , Lieberman J.
J. Biol. Chem.276:43285-43293(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS SET PROTEASE
11.

"Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor."
Fan Z. , Beresford P.J. , Oh D.Y. , Zhang D. , Lieberman J.
Cell112:659-672(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS SET PROTEASE
12.

"Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A."
Fan Z. , Beresford P.J. , Zhang D. , Xu Z. , Novina C.D. , Yoshida A. , Pommier Y. , Lieberman J.
Nat. Immunol.4:145-153(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH APEX1
13.

"The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death."
Chowdhury D. , Beresford P.J. , Zhu P. , Zhang D. , Sung J.S. , Demple B. , Perrino F.W. , Lieberman J.
Mol. Cell23:133-142(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS SET PROTEASE
14.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-170
tissue: Liver.
15.

"Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes."
Murphy M.E.P. , Moult J. , Bleackley R.C. , Gershenfeld H. , Weissman I.L. , James M.N.G.
Proteins4:190-204(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 29-262
16.

"The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity."
Bell J.K. , Goetz D.H. , Mahrus S. , Harris J.L. , Fletterick R.J. , Craik C.S.
Nat. Struct. Biol.10:527-534(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 29-262 IN COMPLEX WITH A TRIPEPTIDE CMK INHIBITOR
17.

"Crystal structure of the apoptosis-inducing human granzyme A dimer."
Hink-Schauer C. , Estebanez-Perpina E. , Kurschus F.C. , Bode W. , Jenne D.E.
Nat. Struct. Biol.10:535-540(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 29-262 IN COMPLEX WITH SUBSTRATE

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