GZMM ELISA Kit for Human(Homo sapiens) | EIAab.comGZMM ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GZMM(Gene name) > Human

GZMM (Gene name),

Granzyme M (Protein name ), GRAM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GZMM(MET1);

Protein name:

Granzyme M;

Alternative:

Met-ase;Met-1 serine protease(Hu-Met-1);Natural killer cell granular protease;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.

Subcellular Location:

Secreted Cytoplasmic granule Granules of large granular lymphocytes.

Protein Attributes:

Sequence length:

257

Sequence:

50:

100:

150:

200:

250:

257:

KVTGRSA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P51124

SMR:

P51124

MIM:

600311

Pfam:

PF00089

KEGG:

hsa:3004

STRING:

9606.ENSP00000264553

UniGene:

Hs.465511

Uniprot:

P51124

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ELISA Kit for Human Granzyme M

Cat.:

E2148h

Price:

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Granzyme M

Cat.:

E2148r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Granzyme M

Cat.:

U2148h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Granzyme M

Cat.:

U2148r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Granzyme M

Cat.:

P2148Rb-r

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Granzyme M

Cat.:

P2148Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Granzyme M

Protein for Human Granzyme M

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells."
Smyth M.J. , Sayers T.J. , Wiltrout T. , Powers J.C. , Trapani J.A.
J. Immunol.151:6195-6205(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT GLY-221
2.

"The human Met-ase gene (GZMM): structure, sequence, and close physical linkage to the serine protease gene cluster on 19p13.3."
Pilat D. , Fink T.M. , Obermaier-Skrobanek B. , Zimmer M. , Wekerle H. , Lichter P. , Jenne D.E.
Genomics24:445-450(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-221
3.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLY-221
tissue: Pancreas.
tissue: Spleen.
5.

"NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network."
Bovenschen N. , de Koning P.J. , Quadir R. , Broekhuizen R. , Damen J.M. , Froelich C.J. , Slijper M. , Kummer J.A.
J. Immunol.180:8184-8191(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBSTRATES
6.

"Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells."
Hu D. , Liu S. , Shi L. , Li C. , Wu L. , Fan Z.
J. Biol. Chem.285:18326-18335(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M."
Wu L. , Wang L. , Hua G. , Liu K. , Yang X. , Zhai Y. , Bartlam M. , Sun F. , Fan Z.
J. Immunol.183:421-429(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 26-257;ACTIVE SITE;DISULFIDE BONDS

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