Gene name:
GREM1 (PIG2;CKTSF1B1;DAND2;DRM) ;
Protein name:
Gremlin-1 ;
Alternative:
Cysteine knot superfamily 1, BMP antagonist 1 ;Cell proliferation-inducing gene 2 protein ;Down-regulated in Mos-transformed cells protein ;DAN domain family member 2 ;Increased in high glucose protein 2 (IHG-2) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.
Function:
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.
Subcellular Location:
Secreted
Protein Attributes:
50:
MSRTAYTVGA | LLLLLGTLLP | AAEGKKKGSQ | GAIPPPDKAQ | HNDSEQTQSP |
100:
QQPGSRNRGR | GQGRGTAMPG | EEVLESSQEA | LHVTERKYLK | RDWCKTQPLK |
150:
QTIHEEGCNS | RTIINRFCYG | QCNSFYIPRH | IRKEEGSFQS | CSFCKPKKFT |
184:
TMMVTLNCPE | LQPPTKKKRV | TRVKQCRCIS | IDLD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
ELISA Kit for Human Gremlin-1
ELISA Kit for Human Gremlin-1
ELISA Kit for Human Gremlin-1
ELISA Kit for Human Gremlin-1
CLIA Kit for Human Gremlin-1
CLIA Kit for Human Gremlin-1
CLIA Kit for Human Gremlin-1
CLIA Kit for Human Gremlin-1
Polyclonal Antibody for Human Gremlin-1
Polyclonal Antibody for Human Gremlin-1
Polyclonal Antibody for Human Gremlin-1
Polyclonal Antibody for Human Gremlin-1
Monoclonal Antibody for Human Gremlin-1
Monoclonal Antibody for Human Gremlin-1
Monoclonal Antibody for Human Gremlin-1
Monoclonal Antibody for Human Gremlin-1
Protein for Human Gremlin-1
Protein for Human Gremlin-1
Protein for Human Gremlin-1
Protein for Human Gremlin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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