GREM1 ELISA Kit for Human(Homo sapiens) | EIAab.comGREM1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GREM1(Gene name) > Human

GREM1 (Gene name),

Gremlin-1 (Protein name ), GREM1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GREM1(PIG2;CKTSF1B1;DAND2;DRM);

Protein name:

Gremlin-1;

Alternative:

Cysteine knot superfamily 1, BMP antagonist 1;Cell proliferation-inducing gene 2 protein;Down-regulated in Mos-transformed cells protein;DAN domain family member 2;Increased in high glucose protein 2(IHG-2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.

Function:

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

184

Sequence:

50:

100:

150:

184:

TMMVTLNCPE | LQPPTKKKRV | TRVKQCRCIS | IDLD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O60565

UniGene:

Hs.40098

MIM:

603054

STRING:

9606.ENSP00000300177

String:

O60565

MIM:

601228

KEGG:

hsa:26585

Pfam:

PF03045

Uniprot:

O60565

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ELISA Kit for Human Gremlin-1

Cat.:

E2130h

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96T

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ELISA Kit for Human Gremlin-1

Cat.:

E2130m

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96T

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ELISA Kit for Human Gremlin-1

Cat.:

E2130r

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96T

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ELISA Kit for Human Gremlin-1

Cat.:

E2130c

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96T

CLIA Kit for Human Gremlin-1

Cat.:

U2130m

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MSDS:

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Packing:

96T

CLIA Kit for Human Gremlin-1

Cat.:

U2130h

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Packing:

96T

CLIA Kit for Human Gremlin-1

Cat.:

U2130r

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96T

CLIA Kit for Human Gremlin-1

Cat.:

U2130c

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96T

Polyclonal Antibody for Human Gremlin-1

Cat.:

P2130Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gremlin-1

Cat.:

P2130Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gremlin-1

Cat.:

P2130Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gremlin-1

Monoclonal Antibody for Human Gremlin-1

Protein for Human Gremlin-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities."
Hsu D.R. , Economides A.N. , Wang X. , Eimon P.M. , Harland R.M.
Mol. Cell1:673-683(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1."
McMahon R. , Murphy M. , Clarkson M. , Taal M. , Mackenzie H.S. , Godson C. , Martin F. , Brady H.R.
J. Biol. Chem.275:9901-9904(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
3.

"DRM/GREMLIN (CKTSF1B1) maps to human chromosome 15 and is highly expressed in adult and fetal brain."
Topol L.Z. , Modi W.S. , Koochekpour S. , Blair D.G.
Cytogenet. Cell Genet.89:79-84(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INDUCTION
tissue: Small intestine.
4.

"Human Gremlin homologue."
Tate G. , Mitsuya T.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Identification of a human cell proliferation gene."
Kim J.W.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Chondrocyte.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
8.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-39
9.

"Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1."
Jaeger E. , Leedham S. , Lewis A. , Segditsas S. , Becker M. , Cuadrado P.R. , Davis H. , Kaur K. , Heinimann K. , Howarth K. , East J. , Taylor J. , Thomas H. , Tomlinson I.
Nat. Genet.44:699-703(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INVOLVEMENT IN HMPS1

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