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Index > Protein center > HIST2H2BE(Gene name) > Human
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  • HIST2H2BE (Gene name),
  • Histone H2B type 2-E (Protein name ),  H2B2E_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HIST2H2BE(H2BFQ);
    Protein name:
    Histone H2B type 2-E;
    Alternative:
    Histone H2B.q(H2B/q);Histone H2B-GL105;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    Function:
    Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
    Subcellular Location:
    Nucleus Chromosome
    Protein Attributes:
    Sequence length:
    126
    Sequence:
    50:
    MPEPAKSAPA | PKKGSKKAVT | KAQKKDGKKR | KRSRKESYSI | YVYKVLKQVH | 
    100:
    PDTGISSKAM | GIMNSFVNDI | FERIAGEASR | LAHYNKRSTI | TSREIQTAVR | 
    126:
    LLLPGELAKH | AVSEGTKAVT | KYTSSK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Histone H2B type 2-E
    Cat.:
    E5815h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Histone H2B type 2-E
    Cat.:
    E5815m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Histone H2B type 2-E
    Cat.:
    U5815h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Histone H2B type 2-E
    Cat.:
    U5815m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Histone H2B type 2-E
    Cat.:
    P5815Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Histone H2B type 2-E
    Cat.:
    P5815Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Histone H2B type 2-E
    Monoclonal Antibody for Human Histone H2B type 2-E
    Protein for Human Histone H2B type 2-E
    Protein for Human Histone H2B type 2-E

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A human histone H2B.1 variant gene, located on chromosome 1, utilizes alternative 3' end processing."
      Collart D. , Romain P.L. , Huebner K. , Pockwinse S. , Pilapil S. , Cannizzaro L.A. , Lian J.B. , Croce C.M. , Stein J.L. , Stein G.S.
      J. Cell. Biochem.50:374-385(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Lymphocyte.
    2. 2.
      "The human and mouse replication-dependent histone genes."
      Marzluff W.F. , Gongidi P. , Woods K.R. , Jin J. , Maltais L.J.
      Genomics80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
      tissue: Ovary.
    8. 8.
      "Endotoxin-neutralizing antimicrobial proteins of the human placenta."
      Kim H.S. , Cho J.H. , Park H.W. , Yoon H. , Kim M.S. , Kim S.C.
      J. Immunol.168:2356-2364(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21;FUNCTION
    9. 9.
      "Biochemical and antibacterial analysis of human wound and blister fluid."
      Frohm M. , Gunne H. , Bergman A.-C. , Agerberth B. , Bergman T. , Boman A. , Liden S. , Joernvall H. , Boman H.G.
      Eur. J. Biochem.237:86-92(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13
    10. 10.
      "Antimicrobial peptides in the first line defence of human colon mucosa."
      Tollin M. , Bergman P. , Svenberg T. , Joernvall H. , Gudmundsson G.H. , Agerberth B.
      Peptides24:523-530(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13;FUNCTION
    11. 11.
      "Antimicrobial polypeptides of the human colonic epithelium."
      Howell S.J. , Wilk D. , Yadav S.P. , Bevins C.L.
      Peptides24:1763-1770(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13;FUNCTION
    12. 12.
      "Quantitative proteomic analysis of post-translational modifications of human histones."
      Beck H.C. , Nielsen E.C. , Matthiesen R. , Jensen L.H. , Sehested M. , Finn P. , Grauslund M. , Hansen A.M. , Jensen O.N.
      Mol. Cell. Proteomics5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 7-24;ACETYLATION AT LYS-6; LYS-12; LYS-13; LYS-16; LYS-17 AND LYS-21;METHYLATION AT LYS-47; LYS-58 AND LYS-109;UBIQUITINATION AT LYS-121;IDENTIFICATION BY MASS SPECTROMETRY
    13. 13.
      "Isolation and characterization of a cDNA from a human histone H2B gene which is reciprocally expressed in relation to replication-dependent H2B histone genes during HL60 cell differentiation."
      Collart D. , Ramsey-Ewing A. , Bortell R. , Lian J. , Stein J. , Stein G.
      Biochemistry30:1610-1617(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-126
      tissue: Liver.
    14. 14.
      "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase."
      Cheung W.L. , Ajiro K. , Samejima K. , Kloc M. , Cheung P. , Mizzen C.A. , Beeser A. , Etkin L.D. , Chernoff J. , Earnshaw W.C. , Allis C.D.
      Cell113:507-517(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-15
    15. 15.
      "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation."
      Zhu B. , Zheng Y. , Pham A.-D. , Mandal S.S. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
      Mol. Cell20:601-611(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-121
    16. 16.
      "Inhibition of core histones acetylation by carcinogenic nickel(II)."
      Golebiowski F. , Kasprzak K.S.
      Mol. Cell. Biochem.279:133-139(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-6; LYS-13; LYS-16 AND LYS-21
    17. 17.
      "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II."
      Pavri R. , Zhu B. , Li G. , Trojer P. , Mandal S. , Shilatifard A. , Reinberg D.
      Cell125:703-717(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-121
    18. 18.
      "Gene-specific characterization of human histone H2B by electron capture dissociation."
      Siuti N. , Roth M.J. , Mizzen C.A. , Kelleher N.L. , Pesavento J.J.
      J. Proteome Res.5:233-239(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY
    19. 19.
      "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."
      Tan M. , Luo H. , Lee S. , Jin F. , Yang J.S. , Montellier E. , Buchou T. , Cheng Z. , Rousseaux S. , Rajagopal N. , Lu Z. , Ye Z. , Zhu Q. , Wysocka J. , Ye Y. , Khochbin S. , Ren B. , Zhao Y.
      Cell146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CROTONYLATION AT LYS-6; LYS-12; LYS-13; LYS-16; LYS-17; LYS-21; LYS-24 AND LYS-35
    20. 20.
      "The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."
      Wu L. , Zee B.M. , Wang Y. , Garcia B.A. , Dou Y.
      Mol. Cell43:132-144(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-35
    21. 21.
      "USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."
      Zhang Z. , Jones A. , Joo H.Y. , Zhou D. , Cao Y. , Chen S. , Erdjument-Bromage H. , Renfrow M. , He H. , Tempst P. , Townes T.M. , Giles K.E. , Ma L. , Wang H.
      Genes Dev.27:1581-1595(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP49
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