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Index > Protein center > HACE1(Gene name) > Human
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  • HACE1 (Gene name),
  • E3 ubiquitin-protein ligase HACE1 (Protein name ),  HACE1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HACE1(KIAA1320);
    Protein name:
    E3 ubiquitin-protein ligase HACE1;
    Alternative:
    HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
    Function:
    E3 ubiquitin-protein ligase that may function in cellular proteins degradation.
    Subcellular Location:
    Cytoplasm Endoplasmic reticulum A significant portion localizes to the endoplasmic reticulum.
    Protein Attributes:
    Sequence length:
    909
    Sequence:
    50:
    MERAMEQLNR | LTRSLRRART | VELPEDNETA | VYTLMPMVMA | DQHRSVSELL | 
    100:
    SNSKFDVNYA | FGRVKRSLLH | IAANCGSVEC | LVLLLKKGAN | PNYQDISGCT | 
    150:
    PLHLAARNGQ | KKCMSKLLEY | SADVNICNNE | GLTAIHWLAV | NGRTELLHDL | 
    200:
    VQHVSDVDVE | DAMGQTALHV | ACQNGHKTTV | QCLLDSGADI | NRPNVSGATP | 
    250:
    LYFACSHGQR | DTAQILLLRG | AKYLPDKNGV | TPLDLCVQGG | YGETCEVLIQ | 
    300:
    YHPRLFQTII | QMTQNEDLRE | NMLRQVLEHL | SQQSESQYLK | ILTSLAEVAT | 
    350:
    TNGHKLLSLS | SNYDAQMKSL | LRIVRMFCHV | FRIGPSSPSN | GIDMGYNGNK | 
    400:
    TPRSQVFKPL | ELLWHSLDEW | LVLIATELMK | NKRDSTEITS | ILLKQKGQDQ | 
    450:
    DAASIPPFEP | PGPGSYENLS | TGTRESKPDA | LAGRQEASAD | CQDVISMTAN | 
    500:
    RLSAVIQAFY | MCCSCQMPPG | MTSPRFIEFV | CKHDEVLKCF | VNRNPKIIFD | 
    550:
    HFHFLLECPE | LMSRFMHIIK | AQPFKDRCEW | FYEHLHSGQP | DSDMVHRPVN | 
    600:
    ENDILLVHRD | SIFRSSCEVV | SKANCAKLKQ | GIAVRFHGEE | GMGQGVVREW | 
    650:
    FDILSNEIVN | PDYALFTQSA | DGTTFQPNSN | SYVNPDHLNY | FRFAGQILGL | 
    700:
    ALNHRQLVNI | YFTRSFYKHI | LGIPVNYQDV | ASIDPEYAKN | LQWILDNDIS | 
    750:
    DLGLELTFSV | ETDVFGAMEE | VPLKPGGGSI | LVTQNNKAEY | VQLVTELRMT | 
    800:
    RAIQPQINAF | LQGFHMFIPP | SLIQLFDEYE | LELLLSGMPE | IDVSDWIKNT | 
    850:
    EYTSGYERED | PVIQWFWEVV | EDITQEERVL | LLQFVTGSSR | VPHGGFANIM | 
    900:
    GGSGLQNFTI | AAVPYTPNLL | PTSSTCINML | KLPEYPSKEI | LKDRLLVALH | 
    909:
    CGSYGYTMA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    MIM:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase HACE1
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    ELISA Kit for Human E3 ubiquitin-protein ligase HACE1
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    ELISA Kit for Human E3 ubiquitin-protein ligase HACE1
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    CLIA Kit for Human E3 ubiquitin-protein ligase HACE1
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    CLIA Kit for Human E3 ubiquitin-protein ligase HACE1
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    U4918m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human E3 ubiquitin-protein ligase HACE1
    MSDS:
    Please sign in first.
    CLIA Kit for Human E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human E3 ubiquitin-protein ligase HACE1
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    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
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    P4918Rb-h
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    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
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    P4918Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase HACE1
    Protein for Human E3 ubiquitin-protein ligase HACE1
    Protein for Human E3 ubiquitin-protein ligase HACE1
    Protein for Human E3 ubiquitin-protein ligase HACE1
    Protein for Human E3 ubiquitin-protein ligase HACE1
    Protein for Human E3 ubiquitin-protein ligase HACE1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4)
      tissue: Amygdala.
      tissue: Placenta.
      tissue: Thalamus.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS HIS-17 AND THR-374
      tissue: Testis.
    6. 6.
      "Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney."
      Anglesio M.S. , Evdokimova V. , Melnyk N. , Zhang L. , Fernandez C.V. , Grundy P.E. , Leach S. , Marra M.A. , Brooks-Wilson A.R. , Penninger J. , Sorensen P.H.B.
      Hum. Mol. Genet.13:2061-2074(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;MUTAGENESIS OF CYS-876;INTERACTION WITH THE 20S CORE PROTEASOMAL SUBUNIT;SUBCELLULAR LOCATION;INDUCTION
    7. 7.
      "The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers."
      Zhang L. , Anglesio M.S. , O'Sullivan M. , Zhang F. , Yang G. , Sarao R. , Mai P.N. , Cronin S. , Hara H. , Melnyk N. , Li L. , Wada T. , Liu P.P. , Farrar J. , Arceci R.J. , Sorensen P.H. , Penninger J.M.
      Nat. Med.13:1060-1069(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WILMS TUMOR;INDUCTION
    8. 8.
      "Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene."
      Slade I. , Stephens P. , Douglas J. , Barker K. , Stebbings L. , Abbaszadeh F. , Pritchard-Jones K. , Cole R. , Pizer B. , Stiller C. , Vujanic G. , Scott R.H. , Stratton M.R. , Rahman N.
      J. Med. Genet.47:342-347(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WILMS TUMOR;CHROMOSOMAL TRANSLOCATION
    9. 9.
      "The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1."
      Torrino S. , Visvikis O. , Doye A. , Boyer L. , Stefani C. , Munro P. , Bertoglio J. , Gacon G. , Mettouchi A. , Lemichez E.
      Dev. Cell21:959-965(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-876
    10. 10.
      "The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycle."
      Tang D. , Xiang Y. , De Renzis S. , Rink J. , Zheng G. , Zerial M. , Wang Y.
      Nat. Commun.2:501-501(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-876;INTERACTION WITH RAB1; RAB4 AND RAB11
    11. 11.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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