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Index > Protein center > HADH(Gene name) > Human
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  • HADH (Gene name),
  • Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (Protein name ),  HCDH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HADH(HAD;HADHSC;SCHAD);
    Protein name:
    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial(HCDH);
    Alternative:
    Short-chain 3-hydroxyacyl-CoA dehydrogenase;Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    314
    Sequence:
    50:
    MAFVTRQFMR | SVSSSSTASA | SAKKIIVKHV | TVIGGGLMGA | GIAQVAAATG | 
    100:
    HTVVLVDQTE | DILAKSKKGI | EESLRKVAKK | KFAENLKAGD | EFVEKTLSTI | 
    150:
    ATSTDAASVV | HSTDLVVEAI | VENLKVKNEL | FKRLDKFAAE | HTIFASNTSS | 
    200:
    LQITSIANAT | TRQDRFAGLH | FFNPVPVMKL | VEVIKTPMTS | QKTFESLVDF | 
    250:
    SKALGKHPVS | CKDTPGFIVN | RLLVPYLMEA | IRLYERGDAS | KEDIDTAMKL | 
    300:
    GAGYPMGPFE | LLDYVGLDTT | KFIVDGWHEM | DAENPLHQPS | PSLNKLVAEN | 
    314:
    KFGKKTGEGF | YKYK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    SMR:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human HCDH
    Cat.:
    E15080h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human HCDH
    Cat.:
    E15080p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HCDH
    MSDS:
    Please sign in first.
    ELISA Kit for Human HCDH
    MSDS:
    Please sign in first.
    CLIA Kit for Human HCDH
    MSDS:
    Please sign in first.
    CLIA Kit for Human HCDH
    MSDS:
    Please sign in first.
    CLIA Kit for Human HCDH
    MSDS:
    Please sign in first.
    CLIA Kit for Human HCDH
    Cat.:
    U15080h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HCDH
    Polyclonal Antibody for Human HCDH
    Polyclonal Antibody for Human HCDH
    Polyclonal Antibody for Human HCDH
    Monoclonal Antibody for Human HCDH
    Monoclonal Antibody for Human HCDH
    Monoclonal Antibody for Human HCDH
    Monoclonal Antibody for Human HCDH
    Protein for Human HCDH
    Protein for Human HCDH
    Protein for Human HCDH
    Protein for Human HCDH

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    Linearity
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    References
    1. 1.
      "Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence."
      Vredendaal P.J.C.M. , van den Berg I.E.T. , Malingre H.E.M. , Stroobants A.K. , Oldeweghuis D.E.M. , Berger R.
      Biochem. Biophys. Res. Commun.223:718-723(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-86 AND HIS-152
      tissue: Liver.
    2. 2.
      "Cloning of a L-3-hydroxyacyl CoA dehydrogenase that binds to GLUT4 glucose transporter cytoplasmic C-terminus: possible crosstalk between glucose transport and fatty acid metabolism."
      Shi Y. , Samuel S.J. , Lee W. , Yu C.H. , Zhang W. , Lachaal M. , Jung C.Y.
      Submitted (1996-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [MRNA] OF 7-314 (ISOFORM 1);VARIANT PRO-86
      tissue: Skeletal muscle.
    3. 3.
      "Human short chain L-3-hydroxyacyl-CoA dehydrogenase."
      O'Brien L.K. , Sims H.F. , Strauss A.W.
      Submitted (1998-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-86
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-86
      tissue: Lung.
    6. 6.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-185; LYS-202; LYS-241 AND LYS-312;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism."
      Barycki J.J. , O'Brien L.K. , Bratt J.M. , Zhang R. , Sanishvili R. , Strauss A.W. , Banaszak L.J.
      Biochemistry38:5786-5798(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-314 IN COMPLEX WITH SUBSTRATE AND NAD
    9. 9.
      "Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase."
      Barycki J.J. , O'Brien L.K. , Strauss A.W. , Banaszak L.J.
      J. Biol. Chem.275:27186-27196(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 13-314 IN COMPLEX WITH SUBSTRATE AND NAD
    10. 10.
      "3-hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease."
      Yang S.-Y. , He X.-Y. , Schulz H.
      FEBS J.272:4874-4883(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Fulminant hepatic failure associated with mutations in the medium and short chain L-3-hydroxyacyl-CoA dehydrogenase gene."
      O'Brien L.K. , Rinaldo P. , Sims H.F. , Alonso E.M. , Charrow J. , Jones P.M. , Bennett M.J. , Barycki J.J. , Banaszak L.J. , Strauss A.W.
      J. Inherit. Metab. Dis. 23 Suppl.1:127-127(2000)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HADH DEFICIENCY THR-40 AND GLU-57
    12. 12.
      "Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion."
      Clayton P.T. , Eaton S. , Aynsley-Green A. , Edginton M. , Hussain K. , Krywawych S. , Datta V. , Malingre H.E.M. , Berger R. , van den Berg I.E.T.
      J. Clin. Invest.108:457-465(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHF4 LEU-258;CHARACTERIZATION OF VARIANT HHF4 LEU-258
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