HCN4 ELISA Kit for Human(Homo sapiens) | EIAab.comHCN4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HCN4(Gene name) > Human

HCN4 (Gene name),

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (Protein name ), HCN4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HCN4;

Protein name:

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.

Function:

Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1203

Sequence:

50:

100:

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300:

350:

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650:

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950:

1000:

1050:

1100:

1150:

1200:

1203:

SNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9Y3Q4

UniGene:

Hs.86941

SMR:

Q9Y3Q4

Pfam:

PF00027

STRING:

9606.ENSP00000261917

KEGG:

hsa:10021

MIM:

163800

Uniprot:

Q9Y3Q4

FOR

ELISA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cat.:

E13654h

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96T

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ELISA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cat.:

E13654r

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Manual:

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96T

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ELISA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cat.:

E13654m

Price:

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Manual:

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96T

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ELISA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

MSDS:

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CLIA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

MSDS:

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CLIA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cat.:

U13654h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Cat.:

U13654m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

MSDS:

Please sign in first.

Polyclonal Antibody for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Monoclonal Antibody for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Protein for Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Two pacemaker channels from human heart with profoundly different activation kinetics."
Ludwig A. , Zong X. , Stieber J. , Hullin R. , Hofmann F. , Biel M.
EMBO J.18:2323-2329(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Heart.
2.

"Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis."
Seifert R. , Scholten A. , Gauss R. , Mincheva A. , Lichter P. , Kaupp U.B.
Proc. Natl. Acad. Sci. U.S.A.96:9391-9396(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Thalamus.
3.

"Role of HCN4 channel in preventing ventricular arrhythmia."
Ueda K. , Hirano Y. , Higashiuesato Y. , Aizawa Y. , Hayashi T. , Inagaki N. , Tana T. , Ohya Y. , Takishita S. , Muratani H. , Hiraoka M. , Kimura A.
J. Hum. Genet.54:115-121(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT IN BRGDA8
4.

"Structural basis for the cAMP-dependent gating in the human HCN4 channel."
Xu X. , Vysotskaya Z.V. , Liu Q. , Zhou L.
J. Biol. Chem.285:37082-37091(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 521-739 IN COMPLEX WITH CAMP;NUCLEOTIDE-BINDING;FUNCTION;ENZYME REGULATION;SUBUNIT
5.

"Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels."
Lolicato M. , Nardini M. , Gazzarrini S. , Moller S. , Bertinetti D. , Herberg F.W. , Bolognesi M. , Martin H. , Fasolini M. , Bertrand J.A. , Arrigoni C. , Thiel G. , Moroni A.
J. Biol. Chem.286:44811-44820(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 521-723 IN COMPLEX WITH CAMP;NUCLEOTIDE-BINDING;ENZYME REGULATION;SUBUNIT
6.

"Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel."
Xu X. , Marni F. , Wu S. , Su Z. , Musayev F. , Shrestha S. , Xie C. , Gao W. , Liu Q. , Zhou L.
Structure20:2116-2123(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 521-724;CHARACTERIZATION OF VARIANT SSS2 ARG-672
7.

"Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia."
Ueda K. , Nakamura K. , Hayashi T. , Inagaki N. , Takahashi M. , Arimura T. , Morita H. , Higashiuesato Y. , Hirano Y. , Yasunami M. , Takishita S. , Yamashina A. , Ohe T. , Sunamori M. , Hiraoka M. , Kimura A.
J. Biol. Chem.279:27194-27198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CARDIAC ARRHYTHMIA ASN-553
8.

"Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel."
Milanesi R. , Baruscotti M. , Gnecchi-Ruscone T. , DiFrancesco D.
N. Engl. J. Med.354:151-157(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SSS2 ARG-672;FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;CHARACTERIZATION OF VARIANT SSS2 ARG-672
9.

"A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews."
Laish-Farkash A. , Glikson M. , Brass D. , Marek-Yagel D. , Pras E. , Dascal N. , Antzelevitch C. , Nof E. , Reznik H. , Eldar M. , Luria D.
J. Cardiovasc. Electrophysiol.21:1365-1372(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SSS2 VAL-485;CHARACTERIZATION OF VARIANT SSS2 VAL-485

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