Gene name:
HDAC6 (JM21;KIAA0901) ;
Protein name:
Histone deacetylase 6 (HD6) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD.
Function:
In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degradated by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.
Subcellular Location:
Nucleus
Cytoplasm
It is mainly cytoplasmic, where it is associated with microtubules.
Protein Attributes:
50:
MTSTGQDSTT | TRQRRSRQNP | QSPPQDSSVT | SKRNIKKGAV | PRSIPNLAEV |
100:
KKKGKMKKLG | QAMEEDLIVG | LQGMDLNLEA | EALAGTGLVL | DEQLNEFHCL |
150:
WDDSFPEGPE | RLHAIKEQLI | QEGLLDRCVS | FQARFAEKEE | LMLVHSLEYI |
200:
DLMETTQYMN | EGELRVLADT | YDSVYLHPNS | YSCACLASGS | VLRLVDAVLG |
250:
AEIRNGMAII | RPPGHHAQHS | LMDGYCMFNH | VAVAARYAQQ | KHRIRRVLIV |
300:
DWDVHHGQGT | QFTFDQDPSV | LYFSIHRYEQ | GRFWPHLKAS | NWSTTGFGQG |
350:
QGYTINVPWN | QVGMRDADYI | AAFLHVLLPV | ALEFQPQLVL | VAAGFDALQG |
400:
DPKGEMAATP | AGFAQLTHLL | MGLAGGKLIL | SLEGGYNLRA | LAEGVSASLH |
450:
TLLGDPCPML | ESPGAPCRSA | QASVSCALEA | LEPFWEVLVR | STETVERDNM |
500:
EEDNVEESEE | EGPWEPPVLP | ILTWPVLQSR | TGLVYDQNMM | NHCNLWDSHH |
550:
PEVPQRILRI | MCRLEELGLA | GRCLTLTPRP | ATEAELLTCH | SAEYVGHLRA |
600:
TEKMKTRELH | RESSNFDSIY | ICPSTFACAQ | LATGAACRLV | EAVLSGEVLN |
650:
GAAVVRPPGH | HAEQDAACGF | CFFNSVAVAA | RHAQTISGHA | LRILIVDWDV |
700:
HHGNGTQHMF | EDDPSVLYVS | LHRYDHGTFF | PMGDEGASSQ | IGRAAGTGFT |
750:
VNVAWNGPRM | GDADYLAAWH | RLVLPIAYEF | NPELVLVSAG | FDAARGDPLG |
800:
GCQVSPEGYA | HLTHLLMGLA | SGRIILILEG | GYNLTSISES | MAACTRSLLG |
850:
DPPPLLTLPR | PPLSGALASI | TETIQVHRRY | WRSLRVMKVE | DREGPSSSKL |
900:
VTKKAPQPAK | PRLAERMTTR | EKKVLEAGMG | KVTSASFGEE | STPGQTNSET |
950:
AVVALTQDQP | SEAATGGATL | AQTISEAAIG | GAMLGQTTSE | EAVGGATPDQ |
1000:
TTSEETVGGA | ILDQTTSEDA | VGGATLGQTT | SEEAVGGATL | AQTTSEAAME |
1050:
GATLDQTTSE | EAPGGTELIQ | TPLASSTDHQ | TPPTSPVQGT | TPQISPSTLI |
1100:
GSLRTLELGS | ESQGASESQA | PGEENLLGEA | AGGQDMADSM | LMQGSRGLTD |
1150:
QAIFYAVTPL | PWCPHLVAVC | PIPAAGLDVT | QPCGDCGTIQ | ENWVCLSCYQ |
1200:
VYCGRYINGH | MLQHHGNSGH | PLVLSYIDLS | AWCYYCQAYV | HHQALLDVKN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Human HD6
Polyclonal Antibody for Human HD6
Monoclonal Antibody for Human HD6
Monoclonal Antibody for Human HD6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-994
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-994
tissue :
Brain .
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Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASP-1200
tissue :
Ovary .
tissue :
Placenta .
8.
"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
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Mol. Cell. Biol.21:6470-6483(2001)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CBFA2T3
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HDAC11
10.
"The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."
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EMBO J.21:2682-2691(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUMOYLATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;MUTAGENESIS OF HIS-216 AND HIS-611
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIRT2
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY AURKA
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DDIT3
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SIRT2
18.
"A BBSome subunit links ciliogenesis, microtubule stability and acetylation."
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Dev. Cell15:854-865(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BBIP10
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UBD
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORM 2)
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CYLD
22.
"A mutation in the 3'-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia."
Simon D.
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Hum. Mol. Genet.19:2015-2027(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CDP-PBHM
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FAM65B
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1109-1215 IN COMPLEX WITH ZINC IONS
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 1109-1215 IN COMPLEX WITH ZINC IONS AND UBIQUITIN C-TERMINAL PEPTIDE RLRGG