Gene name:
HDAC8 (CDA07;HDACL1) ;
Protein name:
Histone deacetylase 8 (HD8) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
Subcellular Location:
Nucleus
Cytoplasm
Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
Protein Attributes:
50:
MEEPEEPADS | GQSLVPVYIY | SPEYVSMCDS | LAKIPKRASM | VHSLIEAYAL |
100:
HKQMRIVKPK | VASMEEMATF | HTDAYLQHLQ | KVSQEGDDDH | PDSIEYGLGY |
150:
DCPATEGIFD | YAAAIGGATI | TAAQCLIDGM | CKVAINWSGG | WHHAKKDEAS |
200:
GFCYLNDAVL | GILRLRRKFE | RILYVDLDLH | HGDGVEDAFS | FTSKVMTVSL |
250:
HKFSPGFFPG | TGDVSDVGLG | KGRYYSVNVP | IQDGIQDEKY | YQICESVLKE |
300:
VYQAFNPKAV | VLQLGADTIA | GDPMCSFNMT | PVGIGKCLKY | ILQWQLATLI |
350:
LGGGGYNLAN | TARCWTYLTG | VILGKTLSSE | IPDHEFFTAY | GPDYVLEITP |
377:
SCRPDRNEPH | RIQQILNYIK | GNLKHVV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Polyclonal Antibody for Human HD8
Polyclonal Antibody for Human HD8
Polyclonal Antibody for Human HD8
Polyclonal Antibody for Human HD8
Monoclonal Antibody for Human HD8
Monoclonal Antibody for Human HD8
Monoclonal Antibody for Human HD8
Monoclonal Antibody for Human HD8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;FUNCTION
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;MUTAGENESIS OF 142-HIS-HIS-143
tissue :
Uterus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;FUNCTION
tissue :
Heart .
4.
"Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia."
McDonell N.
,
Ramser J.
,
Francis F.
,
Vinet M.-C.
,
Rider S.
,
Sudbrak R.
,
Riesselman L.
,
Yaspo M.-L.
,
Reinhardt R.
,
Monaco A.P.
,
Ross F.
,
Kahn A.
,
Kearney L.
,
Buckle V.
,
Chelly J.
Genomics64:221-229(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Pheochromocytoma .
7.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)
tissue :
Colon .
tissue :
Small intestine .
8.
"The DNA sequence of the human X chromosome."
Ross M.T.
,
Grafham D.V.
,
Coffey A.J.
,
Scherer S.
,
McLay K.
,
Muzny D.
,
Platzer M.
,
Howell G.R.
,
Burrows C.
,
Bird C.P.
,
Frankish A.
,
Lovell F.L.
,
Howe K.L.
,
Ashurst J.L.
,
Fulton R.S.
,
Sudbrak R.
,
Wen G.
,
Jones M.C.
,
Hurles M.E.
,
Andrews T.D.
,
Scott C.E.
,
Searle S.
,
Ramser J.
,
Whittaker A.
,
Deadman R.
,
Carter N.P.
,
Hunt S.E.
,
Chen R.
,
Cree A.
,
Gunaratne P.
,
Havlak P.
,
Hodgson A.
,
Metzker M.L.
,
Richards S.
,
Scott G.
,
Steffen D.
,
Sodergren E.
,
Wheeler D.A.
,
Worley K.C.
,
Ainscough R.
,
Ambrose K.D.
,
Ansari-Lari M.A.
,
Aradhya S.
,
Ashwell R.I.
,
Babbage A.K.
,
Bagguley C.L.
,
Ballabio A.
,
Banerjee R.
,
Barker G.E.
,
Barlow K.F.
,
Barrett I.P.
,
Bates K.N.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Beck A.
,
Bethel G.
,
Blechschmidt K.
,
Brady N.
,
Bray-Allen S.
,
Bridgeman A.M.
,
Brown A.J.
,
Brown M.J.
,
Bonnin D.
,
Bruford E.A.
,
Buhay C.
,
Burch P.
,
Burford D.
,
Burgess J.
,
Burrill W.
,
Burton J.
,
Bye J.M.
,
Carder C.
,
Carrel L.
,
Chako J.
,
Chapman J.C.
,
Chavez D.
,
Chen E.
,
Chen G.
,
Chen Y.
,
Chen Z.
,
Chinault C.
,
Ciccodicola A.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Clerc-Blankenburg K.
,
Clifford K.
,
Cobley V.
,
Cole C.G.
,
Conquer J.S.
,
Corby N.
,
Connor R.E.
,
David R.
,
Davies J.
,
Davis C.
,
Davis J.
,
Delgado O.
,
Deshazo D.
,
Dhami P.
,
Ding Y.
,
Dinh H.
,
Dodsworth S.
,
Draper H.
,
Dugan-Rocha S.
,
Dunham A.
,
Dunn M.
,
Durbin K.J.
,
Dutta I.
,
Eades T.
,
Ellwood M.
,
Emery-Cohen A.
,
Errington H.
,
Evans K.L.
,
Faulkner L.
,
Francis F.
,
Frankland J.
,
Fraser A.E.
,
Galgoczy P.
,
Gilbert J.
,
Gill R.
,
Gloeckner G.
,
Gregory S.G.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gu Y.
,
Gwilliam R.
,
Hamilton C.
,
Hart E.A.
,
Hawes A.
,
Heath P.D.
,
Heitmann K.
,
Hennig S.
,
Hernandez J.
,
Hinzmann B.
,
Ho S.
,
Hoffs M.
,
Howden P.J.
,
Huckle E.J.
,
Hume J.
,
Hunt P.J.
,
Hunt A.R.
,
Isherwood J.
,
Jacob L.
,
Johnson D.
,
Jones S.
,
de Jong P.J.
,
Joseph S.S.
,
Keenan S.
,
Kelly S.
,
Kershaw J.K.
,
Khan Z.
,
Kioschis P.
,
Klages S.
,
Knights A.J.
,
Kosiura A.
,
Kovar-Smith C.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leversha M.
,
Lewis L.
,
Liu W.
,
Lloyd C.
,
Lloyd D.M.
,
Loulseged H.
,
Loveland J.E.
,
Lovell J.D.
,
Lozado R.
,
Lu J.
,
Lyne R.
,
Ma J.
,
Maheshwari M.
,
Matthews L.H.
,
McDowall J.
,
McLaren S.
,
McMurray A.
,
Meidl P.
,
Meitinger T.
,
Milne S.
,
Miner G.
,
Mistry S.L.
,
Morgan M.
,
Morris S.
,
Mueller I.
,
Mullikin J.C.
,
Nguyen N.
,
Nordsiek G.
,
Nyakatura G.
,
O'dell C.N.
,
Okwuonu G.
,
Palmer S.
,
Pandian R.
,
Parker D.
,
Parrish J.
,
Pasternak S.
,
Patel D.
,
Pearce A.V.
,
Pearson D.M.
,
Pelan S.E.
,
Perez L.
,
Porter K.M.
,
Ramsey Y.
,
Reichwald K.
,
Rhodes S.
,
Ridler K.A.
,
Schlessinger D.
,
Schueler M.G.
,
Sehra H.K.
,
Shaw-Smith C.
,
Shen H.
,
Sheridan E.M.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.L.
,
Sotheran E.C.
,
Steingruber H.E.
,
Steward C.A.
,
Storey R.
,
Swann R.M.
,
Swarbreck D.
,
Tabor P.E.
,
Taudien S.
,
Taylor T.
,
Teague B.
,
Thomas K.
,
Thorpe A.
,
Timms K.
,
Tracey A.
,
Trevanion S.
,
Tromans A.C.
,
d'Urso M.
,
Verduzco D.
,
Villasana D.
,
Waldron L.
,
Wall M.
,
Wang Q.
,
Warren J.
,
Warry G.L.
,
Wei X.
,
West A.
,
Whitehead S.L.
,
Whiteley M.N.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams G.
,
Williams L.
,
Williamson A.
,
Williamson H.
,
Wilming L.
,
Woodmansey R.L.
,
Wray P.W.
,
Yen J.
,
Zhang J.
,
Zhou J.
,
Zoghbi H.
,
Zorilla S.
,
Buck D.
,
Reinhardt R.
,
Poustka A.
,
Rosenthal A.
,
Lehrach H.
,
Meindl A.
,
Minx P.J.
,
Hillier L.W.
,
Willard H.F.
,
Wilson R.K.
,
Waterston R.H.
,
Rice C.M.
,
Vaudin M.
,
Coulson A.
,
Nelson D.L.
,
Weinstock G.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Gibbs R.A.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature434:325-337(2005)
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Europe PMC ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
10.
"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M.
,
Nip J.
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Strom D.K.
,
Lutterbach B.
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Harada H.
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Lenny N.
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Downing J.R.
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Meyers S.
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Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001)
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Cited for : INTERACTION WITH CBFA2T3
11.
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Cited for : INTERACTION WITH PEPB2-MYH11 FUSION PROTEIN
12.
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Cited for : PHOSPHORYLATION BY PKA;MUTAGENESIS OF SER-39;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
13.
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Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
14.
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Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION
15.
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Cited for : INTERACTION WITH SMG5
16.
"X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face."
Harakalova M.
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van den Boogaard M.J.
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Sinke R.
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van Lieshout S.
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van Tuil M.C.
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Duran K.
,
Renkens I.
,
Terhal P.A.
,
de Kovel C.
,
Nijman I.J.
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van Haelst M.
,
Knoers N.V.
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van Haaften G.
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Kloosterman W.
,
Hennekam R.C.
,
Cuppen E.
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Ploos van Amstel H.K.
J. Med. Genet.49:539-543(2012)
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Cited for : INVOLVEMENT IN WTS
17.
"HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle."
Deardorff M.A.
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Bando M.
,
Nakato R.
,
Watrin E.
,
Itoh T.
,
Minamino M.
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Saitoh K.
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Komata M.
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Katou Y.
,
Clark D.
,
Cole K.E.
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De Baere E.
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Decroos C.
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Di Donato N.
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Ernst S.
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Francey L.J.
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Gyftodimou Y.
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Hirashima K.
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Hullings M.
,
Ishikawa Y.
,
Jaulin C.
,
Kaur M.
,
Kiyono T.
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Lombardi P.M.
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Magnaghi-Jaulin L.
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Mortier G.R.
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Nozaki N.
,
Petersen M.B.
,
Seimiya H.
,
Siu V.M.
,
Suzuki Y.
,
Takagaki K.
,
Wilde J.J.
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Willems P.J.
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Prigent C.
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Gillessen-Kaesbach G.
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Christianson D.W.
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Kaiser F.J.
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Jackson L.G.
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Hirota T.
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Krantz I.D.
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Shirahige K.
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Nature489:313-317(2012)
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Cited for : FUNCTION;VARIANTS CDLS5 ARG-180; MET-311; ARG-320 AND ARG-334
18.
"Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases."
Somoza J.R.
,
Skene R.J.
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Katz B.A.
,
Mol C.
,
Ho J.D.
,
Jennings A.J.
,
Luong C.
,
Arvai A.
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Buggy J.J.
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Chi E.
,
Tang J.
,
Sang B.-C.
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Verner E.
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Wynands R.
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Leahy E.M.
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Dougan D.R.
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Snell G.
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Navre M.
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Knuth M.W.
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Swanson R.V.
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McRee D.E.
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Tari L.W.
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Structure12:1325-1334(2004)
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEXES WITH TSA; SAHA; MS-344; CRA-A AND DIVALENT METAL CATION;ENZYME REGULATION;PHOSPHORYLATION AT SER-39
19.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH DIVALENT METAL CATION;MUTAGENESIS OF ASP-101 AND TYR-306
20.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) IN COMPLEXES WITH PEPTIDE SUBSTRATE; SAHA; TSA; M-344 AND APHA;ACTIVE SITE;MUTAGENESIS OF ASP-101 AND HIS-143