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Index > Protein center > HDAC8(Gene name) > Human
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  • HDAC8 (Gene name),
  • Histone deacetylase 8 (Protein name ),  HDAC8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HDAC8(CDA07;HDACL1);
    Protein name:
    Histone deacetylase 8(HD8);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate in the conversion of RUNX1 into a constitutive transcriptional repressor. Interacts with CBFA2T3. Interacts with phosphorylated SMG5/EST1B; this interaction protects SMG5 from ubiquitin-mediated degradation. Associates with alpha-SMA (smooth muscle alpha-actin).
    Function:
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.
    Subcellular Location:
    Nucleus Cytoplasm Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.
    Protein Attributes:
    Sequence length:
    377
    Sequence:
    50:
    MEEPEEPADS | GQSLVPVYIY | SPEYVSMCDS | LAKIPKRASM | VHSLIEAYAL | 
    100:
    HKQMRIVKPK | VASMEEMATF | HTDAYLQHLQ | KVSQEGDDDH | PDSIEYGLGY | 
    150:
    DCPATEGIFD | YAAAIGGATI | TAAQCLIDGM | CKVAINWSGG | WHHAKKDEAS | 
    200:
    GFCYLNDAVL | GILRLRRKFE | RILYVDLDLH | HGDGVEDAFS | FTSKVMTVSL | 
    250:
    HKFSPGFFPG | TGDVSDVGLG | KGRYYSVNVP | IQDGIQDEKY | YQICESVLKE | 
    300:
    VYQAFNPKAV | VLQLGADTIA | GDPMCSFNMT | PVGIGKCLKY | ILQWQLATLI | 
    350:
    LGGGGYNLAN | TARCWTYLTG | VILGKTLSSE | IPDHEFFTAY | GPDYVLEITP | 
    377:
    SCRPDRNEPH | RIQQILNYIK | GNLKHVV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human HD8
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    E1111h
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    ELISA Kit for Human HD8
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    E1111r
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    ELISA Kit for Human HD8
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    ELISA Kit for Human HD8
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    E1111b
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    CLIA Kit for Human HD8
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    U1111h
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    CLIA Kit for Human HD8
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    CLIA Kit for Human HD8
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    U1111b
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    CLIA Kit for Human HD8
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    U1111r
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    MSDS:
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    Polyclonal Antibody for Human HD8
    Cat.:
    P1111Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HD8
    Polyclonal Antibody for Human HD8
    Cat.:
    P1111Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HD8
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    P1111Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HD8
    Monoclonal Antibody for Human HD8
    Monoclonal Antibody for Human HD8
    Monoclonal Antibody for Human HD8
    Protein for Human HD8
    Protein for Human HD8
    Protein for Human HD8
    Protein for Human HD8

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    References
    1. 1.
      "Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor."
      Hu E. , Chen Z. , Fredrickson T. , Zhu Y. , Kirkpatrick R. , Zhang G.-F. , Johanson K. , Sung C.-M. , Liu R. , Winkler J.
      J. Biol. Chem.275:15254-15264(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;FUNCTION
      tissue: Kidney.
    2. 2.
      "Cloning and characterization of a novel human histone deacetylase, HDAC8."
      Buggy J.J. , Sideris M.L. , Mak P. , Lorimer D.D. , McIntosh B. , Clark J.M.
      Biochem. J.350:199-205(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;MUTAGENESIS OF 142-HIS-HIS-143
      tissue: Uterus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION;FUNCTION
      tissue: Heart.
    4. 4.
      "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia."
      McDonell N. , Ramser J. , Francis F. , Vinet M.-C. , Rider S. , Sudbrak R. , Riesselman L. , Yaspo M.-L. , Reinhardt R. , Monaco A.P. , Ross F. , Kahn A. , Kearney L. , Buckle V. , Chelly J.
      Genomics64:221-229(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    5. 5.
      "Normalization and subtraction: two approaches to facilitate gene discovery."
      Bonaldo M.F. , Lennon G. , Soares M.B.
      Genome Res.6:791-806(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8)
    6. 6.
      "A novel gene expressed in human pheochromocytoma."
      Li Y. , Huang Q. , Peng Y. , Song H. , Yu Y. , Xu S. , Ren S. , Chen Z. , Han Z.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Pheochromocytoma.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)
      tissue: Colon.
      tissue: Small intestine.
    8. 8.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    10. 10.
      "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
      Amann J.M. , Nip J. , Strom D.K. , Lutterbach B. , Harada H. , Lenny N. , Downing J.R. , Meyers S. , Hiebert S.W.
      Mol. Cell. Biol.21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBFA2T3
    11. 11.
      "The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain."
      Durst K.L. , Lutterbach B. , Kummalue T. , Friedman A.D. , Hiebert S.W.
      Mol. Cell. Biol.23:607-619(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PEPB2-MYH11 FUSION PROTEIN
    12. 12.
      "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A."
      Lee H. , Rezai-Zadeh N. , Seto E.
      Mol. Cell. Biol.24:765-773(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY PKA;MUTAGENESIS OF SER-39;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    13. 13.
      "Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility."
      Waltregny D. , Glenisson W. , Tran S.L. , North B.J. , Verdin E. , Colige A. , Castronovo V.
      FASEB J.19:966-968(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    14. 14.
      "Use of histone deacetylase 8 (HDAC8), a new marker of smooth muscle differentiation, in the classification of mesenchymal tumors of the uterus."
      de Leval L. , Waltregny D. , Boniver J. , Young R.H. , Castronovo V. , Oliva E.
      Am. J. Surg. Pathol.30:319-327(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    15. 15.
      "Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation."
      Lee H. , Sengupta N. , Villagra A. , Rezai-Zadeh N. , Seto E.
      Mol. Cell. Biol.26:5259-5269(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMG5
    16. 16.
      "X-exome sequencing identifies a HDAC8 variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face."
      Harakalova M. , van den Boogaard M.J. , Sinke R. , van Lieshout S. , van Tuil M.C. , Duran K. , Renkens I. , Terhal P.A. , de Kovel C. , Nijman I.J. , van Haelst M. , Knoers N.V. , van Haaften G. , Kloosterman W. , Hennekam R.C. , Cuppen E. , Ploos van Amstel H.K.
      J. Med. Genet.49:539-543(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WTS
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS CDLS5 ARG-180; MET-311; ARG-320 AND ARG-334
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) IN COMPLEXES WITH TSA; SAHA; MS-344; CRA-A AND DIVALENT METAL CATION;ENZYME REGULATION;PHOSPHORYLATION AT SER-39
    19. 19.
      "Substrate binding to histone deacetylases as shown by the crystal structure of the HDAC8-substrate complex."
      Vannini A. , Volpari C. , Gallinari P. , Jones P. , Mattu M. , Carfi A. , De Francesco R. , Steinkuehler C. , Di Marco S.
      EMBO Rep.8:879-884(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH DIVALENT METAL CATION;MUTAGENESIS OF ASP-101 AND TYR-306
    20. 20.
      "Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors."
      Dowling D.P. , Gantt S.L. , Gattis S.G. , Fierke C.A. , Christianson D.W.
      Biochemistry47:13554-13563(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) IN COMPLEXES WITH PEPTIDE SUBSTRATE; SAHA; TSA; M-344 AND APHA;ACTIVE SITE;MUTAGENESIS OF ASP-101 AND HIS-143
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