FECH ELISA Kit for Human(Homo sapiens) | EIAab.comFECH ELISA Kit for Human(Homo sapiens)

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Index > Protein center > FECH(Gene name) > Human

FECH (Gene name),

Ferrochelatase, mitochondrial (Protein name ), HEMH_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

FECH;

Protein name:

Ferrochelatase, mitochondrial;

Alternative:

Protoheme ferro-lyase;Heme synthase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Catalyzes the ferrous insertion into protoporphyrin IX.

Subcellular Location:

Mitochondrion inner membrane Peripheral membrane protein Matrix side

Protein Attributes:

Sequence length:

423

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

423:

LSCPLCVNPV | CRETKSFFTS | QQL

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

UniGene:

Hs.365365

String:

P22830

Pfam:

PF00762

STRING:

9606.ENSP00000372326

MIM:

177000

SMR:

P22830

KEGG:

hsa:2235

Uniprot:

P22830

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ELISA Kit for Human Ferrochelatase, mitochondrial

Cat.:

E2083h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Ferrochelatase, mitochondrial

Cat.:

E2083c

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Packing:

96T

ELISA Kit for Human Ferrochelatase, mitochondrial

Cat.:

E2083m

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Packing:

96T

ELISA Kit for Human Ferrochelatase, mitochondrial

Cat.:

E2083b

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Packing:

96T

CLIA Kit for Human Ferrochelatase, mitochondrial

Cat.:

U2083c

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Packing:

96T

CLIA Kit for Human Ferrochelatase, mitochondrial

Cat.:

U2083b

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Packing:

96T

CLIA Kit for Human Ferrochelatase, mitochondrial

Cat.:

U2083m

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MSDS:

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Packing:

96T

CLIA Kit for Human Ferrochelatase, mitochondrial

Cat.:

U2083h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Ferrochelatase, mitochondrial

Cat.:

P2083Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ferrochelatase, mitochondrial

Cat.:

P2083Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Ferrochelatase, mitochondrial

Protein for Human Ferrochelatase, mitochondrial

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Malignant Glioma: MR Imaging by Using 5-Aminolevulinic Acid in an Animal Model"

HR Cho, DH Kim, D Kim, et al.

From:Radiology

References

1.

"Molecular cloning and sequence analysis of cDNA encoding human ferrochelatase."
Nakahashi Y. , Taketani S. , Okuda M. , Inoue K. , Tokunaga R.
Biochem. Biophys. Res. Commun.173:748-755(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT GLN-96
2.

"Ferrochelatase: complete human gene sequence, amplifiable polymorphisms and molecular study of 12 families with erythropoietic protoporphyria."
Gouya L.M. , Martin C. , Deybach J.-C. , Puy H.V.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-96
3.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Placenta.
tissue: Trachea.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
7.

"A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene."
Tugores A. , Magness S.T. , Brenner D.A.
J. Biol. Chem.269:30789-30797(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
8.

"Molecular analysis of ferrochelatase gene in erythropoietic protoporphyria."
Di Pierro E. , Martinez di Montemuros F. , Moriondo V. , Cappellini M.D.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
9.

"Mammalian ferrochelatase. Expression and characterization of normal and two human protoporphyric ferrochelatases."
Dailey H.A. , Sellers V.M. , Dailey T.A.
J. Biol. Chem.269:390-395(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS
10.

"Site-directed mutagenesis and spectroscopic characterization of human ferrochelatase: identification of residues coordinating the [2Fe-2S] cluster."
Crouse B.R. , Sellers V.M. , Finnegan M.G. , Dailey H.A. , Johnson M.K.
Biochemistry35:16222-16229(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF CYSTEINES COORDINATING THE 2FE-2S CLUSTER
11.

"Evidence that the fourth ligand to the 2Fe-2S cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster."
Sellers V.M. , Wang K.-F. , Johnson M.K. , Dailey H.A.
J. Biol. Chem.273:22311-22316(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF CYSTEINES COORDINATING THE 2FE-2S CLUSTER
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis."
Wu C.-K. , Dailey H.A. , Rose J.P. , Burden A. , Sellers V.M. , Wang B.-C.
Nat. Struct. Biol.8:156-160(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
14.

"Substrate interactions with human ferrochelatase."
Medlock A. , Swartz L. , Dailey T.A. , Dailey H.A. , Lanzilotta W.N.
Proc. Natl. Acad. Sci. U.S.A.104:1789-1793(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 65-423 ALONE AND IN COMPLEX WITH PROTOPORPHYRIN IX;SUBUNIT;IRON-SULFUR CLUSTER
15.

"Erythropoietic protoporphyria."
Cox T.M.
J. Inherit. Metab. Dis.20:258-269(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS EPP
16.

"Human erythropoietic protoporphyria: two point mutations in the ferrochelatase gene."
Lamoril J. , Boulechfar S. , de Verneuil H. , Grandchamp B. , Nordmann Y. , Deybach J.-C.
Biochem. Biophys. Res. Commun.181:594-599(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EPP CYS-55 AND ILE-267
17.

"A molecular defect in human protoporphyria."
Brenner D.A. , Didier J.M. , Frasier F. , Christensen S.R. , Evans G.A. , Dailey H.A.
Am. J. Hum. Genet.50:1203-1210(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP SER-417
18.

"Recessive inheritance of erythropoietic protoporphyria with liver failure."
Sarkany R.P.E. , Alexander G.J.M.A. , Cox T.M.
Lancet343:1394-1396(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP GLY-362
19.

"A novel mutation in the ferrochelatase gene associated with erythropoietic protoporphyria."
Imoto S. , Tanizawa Y. , Sata Y. , Kaku K. , Oka Y.
Br. J. Haematol.94:191-197(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP THR-186
20.

"Systematic analysis of molecular defects in the ferrochelatase gene from patients with erythropoietic protoporphyria."
Ruefenacht U.B. , Gouya L. , Schneider-Yin X. , Puy H. , Schaefer B.W. , Aquaron R. , Nordmann Y. , Minder E.I. , Deybach J.-C.
Am. J. Hum. Genet.62:1341-1352(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EPP LYS-71; PRO-151; HIS-191; THR-192; ILE-283; LYS-288; LEU-334 AND PHE-417 DEL;CHARACTERIZATION OF VARIANTS EPP LYS-71; PRO-151; HIS-191; THR-192; ILE-283; LYS-288; LEU-334 AND PHE-417 DEL
21.

"Mutations in the ferrochelatase gene of four Spanish patients with erythropoietic protoporphyria."
Gouya L. , Schneider-Yin X. , Rufenacht U. , Herrero C. , Lecha M. , Mascaro J.M. , Puy H. , Deybach J.-C. , Minder E.I.
J. Invest. Dermatol.111:406-409(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP PRO-386
22.

"Mutations in the iron-sulfur cluster ligands of the human ferrochelatase lead to erythropoietic protoporphyria."
Schneider-Yin X. , Gouya L. , Dorsey M. , Ruefenacht U. , Deybach J.-C. , Ferreira G.C.
Blood96:1545-1549(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EPP SER-406; TYR-406 AND 408-LYS-SER--GLY-411;CHARACTERIZATION OF VARIANTS EPP SER-406; TYR-406 AND 408-LYS-SER--GLY-411
23.

"New missense mutation in the human ferrochelatase gene in a family with erythropoietic protoporphyria: functional studies and correlation of genotype and phenotype."
Ruefenacht U.B. , Gregor A. , Gouya L. , Tarczynska-Nosal S. , Schneider-Yin X. , Deybach J.-C.
Clin. Chem.47:1112-1113(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP ARG-182;CHARACTERIZATION OF VARIANT EPP ARG-182
24.

"Erythropoietic protoporphyria: altered phenotype after bone marrow transplantation for myelogenous leukemia in a patient heteroallelic for ferrochelatase gene mutations."
Poh-Fitzpatrick M.B. , Wang X. , Anderson K.E. , Bloomer J.R. , Bolwell B. , Lichtin A.E.
J. Am. Acad. Dermatol.46:861-866(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP ARG-62
25.

"Novel mutations and phenotypic effect of the splice site modulator IVS3-48C in nine Swedish families with erythropoietic protoporphyria."
Wiman A. , Floderus Y. , Harper P.
J. Hum. Genet.48:70-76(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EPP LYS-178 AND LEU-334
26.

"Autosomal recessive erythropoietic protoporphyria in the United Kingdom: prevalence and relationship to liver disease."
Whatley S.D. , Mason N.G. , Khan M. , Zamiri M. , Badminton M.N. , Missaoui W.N. , Dailey T.A. , Dailey H.A. , Douglas W.S. , Wainwright N.J. , Elder G.H.
J. Med. Genet.41:E105-E105(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS EPP LEU-139; TYR-236; LEU-260 AND ASN-379;CHARACTERIZATION OF VARIANTS EPP LEU-139; TYR-236; LEU-260 AND ASN-379
27.

"Heterogeneity of mutations in the ferrochelatase gene in Italian patients with erythropoietic protoporphyria."
Aurizi C. , Schneider-Yin X. , Sorge F. , Macri A. , Minder E.I. , Biolcati G.
Mol. Genet. Metab.90:402-407(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EPP LEU-264

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