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Index > Protein center > Hexa(Gene name) > Mouse
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  • Hexa (Gene name),
  • Beta-hexosaminidase subunit alpha (Protein name ),  HEXA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Hexa;
    Protein name:
    Beta-hexosaminidase subunit alpha;
    Alternative:
    Beta-N-acetylhexosaminidase subunit alpha(Hexosaminidase subunit A);N-acetyl-beta-glucosaminidase subunit alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    There are 3 forms of beta-hexosaminidase: hexosaminidase A is a trimer composed of one alpha chain, one beta-A chain and one beta-B chain; hexosaminidase B is a tetramer of two beta-A and two beta-B chains; hexosaminidase S is an homodimer of two alpha chains. The two beta chains are derived from the cleavage of a precursor chain.
    Function:
    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
    Subcellular Location:
    Lysosome
    Protein Attributes:
    Sequence length:
    528
    Sequence:
    50:
    MAGCRLWVSL | LLAAALACLA | TALWPWPQYI | QTYHRRYTLY | PNNFQFRYHV | 
    100:
    SSAAQAGCVV | LDEAFRRYRN | LLFGSGSWPR | PSFSNKQQTL | GKNILVVSVV | 
    150:
    TAECNEFPNL | ESVENYTLTI | NDDQCLLASE | TVWGALRGLE | TFSQLVWKSA | 
    200:
    EGTFFINKTK | IKDFPRFPHR | GVLLDTSRHY | LPLSSILDTL | DVMAYNKFNV | 
    250:
    FHWHLVDDSS | FPYESFTFPE | LTRKGSFNPV | THIYTAQDVK | EVIEYARLRG | 
    300:
    IRVLAEFDTP | GHTLSWGPGA | PGLLTPCYSG | SHLSGTFGPV | NPSLNSTYDF | 
    350:
    MSTLFLEISS | VFPDFYLHLG | GDEVDFTCWK | SNPNIQAFMK | KKGFTDFKQL | 
    400:
    ESFYIQTLLD | IVSDYDKGYV | VWQEVFDNKV | KVRPDTIIQV | WREEMPVEYM | 
    450:
    LEMQDITRAG | FRALLSAPWY | LNRVKYGPDW | KDMYKVEPLA | FHGTPEQKAL | 
    500:
    VIGGEACMWG | EYVDSTNLVP | RLWPRAGAVA | ERLWSSNLTT | NIDFAFKRLS | 
    528:
    HFRCELVRRG | IQAQPISVGY | CEQEFEQT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    E0195r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    E0195h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    E0195m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    E0195b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    U0195h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    U0195m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    U0195r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    U0195b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Polyclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    P0195Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    P0195Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Cat.:
    P0195Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Monoclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Monoclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Monoclonal Antibody for Mouse Beta-hexosaminidase subunit alpha
    Protein for Mouse Beta-hexosaminidase subunit alpha
    Protein for Mouse Beta-hexosaminidase subunit alpha
    Protein for Mouse Beta-hexosaminidase subunit alpha
    Protein for Mouse Beta-hexosaminidase subunit alpha

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequence analysis of a cDNA encoding the alpha-subunit of mouse beta-N-acetylhexosaminidase and comparison with the human enzyme."
      Beccari T. , Hoade J. , Orlacchio A. , Stirling J.L.
      Biochem. J.285:593-596(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Testis.
    2. 2.
      "Organization of the gene for the alpha-subunit of mouse beta-N-acetylhexosaminidase (HEXa)."
      Bianconi S. , Beccari T. , Stirling J.L. , Sheardown S. , Orlacchio A.
      Biochem. Mol. Biol. Int.34:579-586(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Structure and expression of the mouse beta-hexosaminidase genes, Hexa and Hexb."
      Yamanaka S. , Johnson O.N. , Norflus F. , Boles D.J. , Proia R.L.
      Genomics21:588-596(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: C57BL/6 X CBA.
      tissue: Liver.
    4. 4.
      "Structural organization, sequence, and expression of the mouse HEXA gene encoding the alpha subunit of hexosaminidase A."
      Wakamatsu N. , Benoit G. , Lamhonwah A.-M. , Zhang Z.-X. , Trasler J.M. , Triggs-Raine B.L. , Gravel R.A.
      Genomics24:110-119(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
      strain: 129/Sv.
      tissue: Liver.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: BALB/c.
      strain: C57BL/6J.
      tissue: Tongue.
    6. 6.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Colon.
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