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Index > Protein center > HEXB(Gene name) > Human
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  • HEXB (Gene name),
  • Beta-hexosaminidase subunit beta (Protein name ),  HEXB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HEXB(HCC7);
    Protein name:
    Beta-hexosaminidase subunit beta;
    Alternative:
    Cervical cancer proto-oncogene 7 protein(HCC-7);Beta-N-acetylhexosaminidase subunit beta(Hexosaminidase subunit B);N-acetyl-beta-glucosaminidase subunit beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    There are 3 forms of beta-hexosaminidase: hexosaminidase A is a trimer composed of one subunit alpha, one subunit beta chain A and one subunit beta chain B; hexosaminidase B is a tetramer of two subunit beta chains A and two subunit beta chains B; hexosaminidase S is an homodimer of two alpha subunits. The two beta chains are derived from the cleavage of the beta subunit.
    Function:
    Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.
    Subcellular Location:
    Lysosome
    Protein Attributes:
    Sequence length:
    556
    Sequence:
    50:
    MELCGLGLPR | PPMLLALLLA | TLLAAMLALL | TQVALVVQVA | EAARAPSVSA | 
    100:
    KPGPALWPLP | LSVKMTPNLL | HLAPENFYIS | HSPNSTAGPS | CTLLEEAFRR | 
    150:
    YHGYIFGFYK | WHHEPAEFQA | KTQVQQLLVS | ITLQSECDAF | PNISSDESYT | 
    200:
    LLVKEPVAVL | KANRVWGALR | GLETFSQLVY | QDSYGTFTIN | ESTIIDSPRF | 
    250:
    SHRGILIDTS | RHYLPVKIIL | KTLDAMAFNK | FNVLHWHIVD | DQSFPYQSIT | 
    300:
    FPELSNKGSY | SLSHVYTPND | VRMVIEYARL | RGIRVLPEFD | TPGHTLSWGK | 
    350:
    GQKDLLTPCY | SRQNKLDSFG | PINPTLNTTY | SFLTTFFKEI | SEVFPDQFIH | 
    400:
    LGGDEVEFKC | WESNPKIQDF | MRQKGFGTDF | KKLESFYIQK | VLDIIATINK | 
    450:
    GSIVWQEVFD | DKAKLAPGTI | VEVWKDSAYP | EELSRVTASG | FPVILSAPWY | 
    500:
    LDLISYGQDW | RKYYKVEPLD | FGGTQKQKQL | FIGGEACLWG | EYVDATNLTP | 
    550:
    RLWPRASAVG | ERLWSSKDVR | DMDDAYDRLT | RHRCRMVERG | IAAQPLYAGY | 
    556:
    CNHENM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    E8893r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    E8893h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    E8893m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    E8893p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    U8893h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    U8893m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    U8893r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-hexosaminidase subunit beta
    Cat.:
    U8893p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Beta-hexosaminidase subunit beta
    Cat.:
    P8893Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-hexosaminidase subunit beta
    Polyclonal Antibody for Human Beta-hexosaminidase subunit beta
    Cat.:
    P8893Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-hexosaminidase subunit beta
    Monoclonal Antibody for Human Beta-hexosaminidase subunit beta
    Monoclonal Antibody for Human Beta-hexosaminidase subunit beta
    Monoclonal Antibody for Human Beta-hexosaminidase subunit beta
    Monoclonal Antibody for Human Beta-hexosaminidase subunit beta
    Protein for Human Beta-hexosaminidase subunit beta
    Protein for Human Beta-hexosaminidase subunit beta
    Protein for Human Beta-hexosaminidase subunit beta
    Protein for Human Beta-hexosaminidase subunit beta

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease."
      Korneluk R.G. , Mahuran D.J. , Neote K. , Klavins M.H. , O'Dowd B.F. , Tropak M. , Willard H.F. , Anderson M.-J. , Lowden J.A. , Gravel R.A.
      J. Biol. Chem.261:8407-8413(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Characterization of the human HEXB gene encoding lysosomal beta-hexosaminidase."
      Neote K. , Bapat B. , Dumbrille-Ross A. , Troxel C. , Schuster S.M. , Mahuran D.J. , Gravel R.A.
      Genomics3:279-286(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Gene encoding the human beta-hexosaminidase beta chain: extensive homology of intron placement in the alpha- and beta-chain genes."
      Proia R.L.
      Proc. Natl. Acad. Sci. U.S.A.85:1883-1887(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Identification of a new proto-oncogene in human cancers."
      Kim J.W.
      Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    7. 8.
      "Synthesis and assembly of a catalytically active lysosomal enzyme, beta-hexosaminidase B, in a cell-free system."
      Sonderfeld-Fresko S. , Proia R.L.
      J. Biol. Chem.263:13463-13469(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-67
    8. 9.
      "Translation initiation in the HEXB gene encoding the beta-subunit of human beta-hexosaminidase."
      Neote K. , Brown C.A. , Mahuran D.J. , Gravel R.A.
      J. Biol. Chem.265:20799-20806(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52
    9. 10.
      "Localization of the pro-sequence within the total deduced primary structure of human beta-hexosaminidase B."
      Stirling J. , Leung A. , Gravel R.A. , Mahuran D.
      FEBS Lett.231:47-50(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 43-57 AND 122-151
    10. 11.
      "Characterization of human placental beta-hexosaminidase I2. Proteolytic processing intermediates of hexosaminidase A."
      Mahuran D.J.
      J. Biol. Chem.265:6794-6799(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-54 AND 315-324
    11. 12.
      "The amino-terminal sequences in the pro-alpha and -beta polypeptides of human lysosomal beta-hexosaminidase A and B are retained in the mature isozymes."
      Hubbes M. , Callahan J. , Gravel R. , Mahuran D.
      FEBS Lett.249:316-320(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 50-59
    12. 13.
      "Proteolytic processing of pro-alpha and pro-beta precursors from human beta-hexosaminidase. Generation of the mature alpha and beta a beta b subunits."
      Mahuran D.J. , Neote K. , Klavins M.H. , Leung A. , Gravel R.A.
      J. Biol. Chem.263:4612-4618(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 122-151 AND 315-340
    13. 14.
      "Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase."
      O'Dowd B.F. , Quan F. , Willard H.F. , Lamhonwah A.-M. , Korneluk R.G. , Lowden J.A. , Gravel R.A. , Mahuran D.J.
      Proc. Natl. Acad. Sci. U.S.A.82:1184-1188(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 226-283
    14. 15.
      "Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase."
      O'Dowd B.F. , Cumming D.A. , Gravel R.A. , Mahuran D.J.
      Biochemistry27:5216-5226(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CARBOHYDRATES
    15. 16.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-327
    16. 17.
      "Complete analysis of the glycosylation and disulfide bond pattern of human beta-hexosaminidase B by MALDI-MS."
      Schuette C.G. , Weisgerber J. , Sandhoff K.
      Glycobiology11:549-556(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS;GLYCOSYLATION AT ASN-84; ASN-142; ASN-190 AND ASN-327
    17. 18.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-84; ASN-323 AND ASN-327
      tissue: Liver.
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 20.
      "Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease."
      Tews I. , Perrakis A. , Oppenheim A. , Dauter Z. , Wilson K.S. , Vorgias C.E.
      Nat. Struct. Biol.3:638-648(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    20. 21.
      "Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease."
      Mark B.L. , Mahuran D.J. , Cherney M.M. , Zhao D. , Knapp S. , James M.N.
      J. Mol. Biol.327:1093-1109(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 50-556;DISULFIDE BONDS
    21. 22.
      "The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease."
      Maier T. , Strater N. , Schuette C.G. , Klingenstein R. , Sandhoff K. , Saenger W.
      J. Mol. Biol.328:669-681(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 42-556;DISULFIDE BONDS
    22. 23.
      "The biochemistry of HEXA and HEXB gene mutations causing GM2 gangliosidosis."
      Mahuran D.J.
      Biochim. Biophys. Acta1096:87-94(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
    23. 24.
      "Molecular basis of an adult form of beta-hexosaminidase B deficiency with motor neuron disease."
      Banerjee P. , Siciliano L. , Oliveri D. , McCabe N.R. , Boyers M.J. , Horwitz A.L. , Li S.-C. , Dawson G.
      Biochem. Biophys. Res. Commun.181:108-115(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 SER-456;VARIANT VAL-207
    24. 25.
      "A novel exon mutation in the human beta-hexosaminidase beta subunit gene affects 3' splice site selection."
      Wakamatsu N. , Kobayashi H. , Miyatake T. , Tsuji S.
      J. Biol. Chem.267:2406-2413(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 LEU-417
    25. 26.
      "Molecular basis of an adult form of Sandhoff disease: substitution of glutamine for arginine at position 505 of the beta-chain of beta-hexosaminidase results in a labile enzyme."
      Bolhuis P.A. , Ponne N.J. , Bikker H. , Baas F. , Vianney de Jong J.M.B.
      Biochim. Biophys. Acta1182:142-146(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 GLN-505
    26. 27.
      "A novel missense mutation (C522Y) is present in the beta-hexosaminidase beta-subunit gene of a Japanese patient with infantile Sandhoff disease."
      Kuroki Y. , Itoh K. , Nadaoka Y. , Tanaka T. , Sakuraba H.
      Biochem. Biophys. Res. Commun.212:564-571(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 TYR-534
    27. 28.
      "A common beta hexosaminidase gene mutation in adult Sandhoff disease patients."
      Gomez-Lira M. , Sangalli A. , Mottes M. , Perusi C. , Pignatti P.F. , Rizzuto N. , Salviati A.
      Hum. Genet.96:417-422(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GM2G2 TYR-309 AND LEU-417
    28. 29.
      "A second, large deletion in the HEXB gene in a patient with infantile Sandhoff disease."
      Zhang Z.-X. , Wakamatsu N. , Akerman B.R. , Mules E.H. , Thomas G.H. , Gravel R.A.
      Hum. Mol. Genet.4:777-780(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 LEU-62
    29. 30.
      "Significance of two point mutations present in each HEXB allele of patients with adult GM2 gangliosidosis (Sandhoff disease) homozygosity for the Ile207-->Val substitution is not associated with a clinical or biochemical phenotype."
      Redonnet-Vernhet I. , Mahuran D.J. , Salvayre R. , Dubas F. , Levade T.
      Biochim. Biophys. Acta1317:127-133(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 GLN-505;VARIANT VAL-207
    30. 31.
      "Molecular basis of heat labile hexosaminidase B among Jews and Arabs."
      Narkis G. , Adam A. , Jaber L. , Pennybacker M. , Proia R.L. , Navon R.
      Hum. Mutat.10:424-429(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 THR-543
    31. 32.
      "Two mutations remote from an exon/intron junction in the beta-hexosaminidase beta-subunit gene affect 3'-splice site selection and cause Sandhoff disease."
      Fujimaru M. , Tanaka A. , Choeh K. , Wakamatsu N. , Sakuraba H. , Isshiki G.
      Hum. Genet.103:462-469(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 ARG-255
    32. 33.
      "A Pro504 --> Ser substitution in the beta-subunit of beta-hexosaminidase A inhibits alpha-subunit hydrolysis of GM2 ganglioside, resulting in chronic Sandhoff disease."
      Hou Y. , McInnes B. , Hinek A. , Karpati G. , Mahuran D.
      J. Biol. Chem.273:21386-21392(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GM2G2 SER-504
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