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Index > Protein center > HIF1A(Gene name) > Human
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  • HIF1A (Gene name),
  • Hypoxia-inducible factor 1-alpha (Protein name ),  HIF1A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HIF1A(BHLHE78;MOP1;PASD8);
    Protein name:
    Hypoxia-inducible factor 1-alpha(HIF-1-alpha;HIF1-alpha);
    Alternative:
    PAS domain-containing protein 8;Member of PAS protein 1;Class E basic helix-loop-helix protein 78(bHLHe78);ARNT-interacting protein;Basic-helix-loop-helix-PAS protein MOP1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the HIF1A beta/ARNT subunit; heterodimerization is required for DNA binding. Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10 (By similarity). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with GNB2L1/RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation.
    Function:
    Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes, including, erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia.
    Protein Attributes:
    Sequence length:
    826
    Sequence:
    50:
    MEGAGGANDK | KKISSERRKE | KSRDAARSRR | SKESEVFYEL | AHQLPLPHNV | 
    100:
    SSHLDKASVM | RLTISYLRVR | KLLDAGDLDI | EDDMKAQMNC | FYLKALDGFV | 
    150:
    MVLTDDGDMI | YISDNVNKYM | GLTQFELTGH | SVFDFTHPCD | HEEMREMLTH | 
    200:
    RNGLVKKGKE | QNTQRSFFLR | MKCTLTSRGR | TMNIKSATWK | VLHCTGHIHV | 
    250:
    YDTNSNQPQC | GYKKPPMTCL | VLICEPIPHP | SNIEIPLDSK | TFLSRHSLDM | 
    300:
    KFSYCDERIT | ELMGYEPEEL | LGRSIYEYYH | ALDSDHLTKT | HHDMFTKGQV | 
    350:
    TTGQYRMLAK | RGGYVWVETQ | ATVIYNTKNS | QPQCIVCVNY | VVSGIIQHDL | 
    400:
    IFSLQQTECV | LKPVESSDMK | MTQLFTKVES | EDTSSLFDKL | KKEPDALTLL | 
    450:
    APAAGDTIIS | LDFGSNDTET | DDQQLEEVPL | YNDVMLPSPN | EKLQNINLAM | 
    500:
    SPLPTAETPK | PLRSSADPAL | NQEVALKLEP | NPESLELSFT | MPQIQDQTPS | 
    550:
    PSDGSTRQSS | PEPNSPSEYC | FYVDSDMVNE | FKLELVEKLF | AEDTEAKNPF | 
    600:
    STQDTDLDLE | MLAPYIPMDD | DFQLRSFDQL | SPLESSSASP | ESASPQSTVT | 
    650:
    VFQQTQIQEP | TANATTTTAT | TDELKTVTKD | RMEDIKILIA | SPSPTHIHKE | 
    700:
    TTSATSSPYR | DTQSRTASPN | RAGKGVIEQT | EKSHPRSPNV | LSVALSQRTT | 
    750:
    VPEEELNPKI | LALQNAQRKR | KMEHDGSLFQ | AVGIGTLLQQ | PDDHAATTSL | 
    800:
    SWKRVKGCKS | SEQNGMEQKT | IILIPSDLAC | RLLGQSMDES | GLPQLTSYDC | 
    826:
    EVNAPIQGSR | NLLQGEELLR | ALDQVN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human HIF-1-alpha
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    E0798h
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    ELISA Kit for Human HIF-1-alpha
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    E0798r
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    96T
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    ELISA Kit for Human HIF-1-alpha
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    E0798m
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    96T
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    ELISA Kit for Human HIF-1-alpha
    Cat.:
    E0798b
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    Packing:
    96T
    ELISA Kit for Human HIF-1-alpha
    Cat.:
    E0798c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HIF-1-alpha
    Cat.:
    U0798c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HIF-1-alpha
    Cat.:
    U0798h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HIF-1-alpha
    Cat.:
    U0798b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HIF-1-alpha
    Cat.:
    U0798m
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human HIF-1-alpha
    Cat.:
    U0798r
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    Packing:
    96T
    Polyclonal Antibody for Human HIF-1-alpha
    Cat.:
    P0798Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HIF-1-alpha
    Cat.:
    P0798Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HIF-1-alpha
    Polyclonal Antibody for Human HIF-1-alpha
    Polyclonal Antibody for Human HIF-1-alpha
    Cat.:
    P0798Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HIF-1-alpha
    Monoclonal Antibody for Human HIF-1-alpha
    Monoclonal Antibody for Human HIF-1-alpha
    Monoclonal Antibody for Human HIF-1-alpha
    Monoclonal Antibody for Human HIF-1-alpha
    Protein for Human HIF-1-alpha
    Protein for Human HIF-1-alpha
    Protein for Human HIF-1-alpha
    Protein for Human HIF-1-alpha
    Cat.:
    R0798h
    Price:
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Human HIF-1-alpha

    R&D Technical Data

    12% SDS-PAGE analysis

              12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells."
      Shan B. , Gerez J. , Haedo M. , Fuertes M. , Theodoropoulou M. , Buchfelder M. , Losa M. , Stalla G.K. , Arzt E. , Renner U.
      Endocr. Relat. Cancer19:13-27(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INDUCTION
    2. 2.
      "Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension."
      Wang G.L. , Jiang B.-H. , Rue E.A. , Semenza G.L.
      Proc. Natl. Acad. Sci. U.S.A.92:5510-5514(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 166-170; 259-289 AND 771-781
    3. 3.
      "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway."
      Hogenesch J.B. , Chan W.K. , Jackiw V.H. , Brown R.C. , Gu Y.-Z. , Pray-Grant M. , Perdew G.H. , Bradfield C.A.
      J. Biol. Chem.272:8581-8593(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Hepatoma.
    4. 4.
      "The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation."
      Iyer N.V. , Leung S.W. , Semenza G.L.
      Genomics52:159-165(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    5. 5.
      "Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes."
      Lukashev D. , Sitkovsky M.
      Hum. Immunol.69:421-425(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING
    6. 6.
      "HIF1a sequence in the Quechua, a high altitude population."
      Rupert J.L. , Hochachka P.W.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    7. 7.
      Sun B. , Zhao H.R. , Yu R.T. , Ni M.S.H.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Glial tumor.
    8. 8.
      "Hypoxia-inducible factor-1 alpha variant isolated from human liver tissue."
      Tanaka S. , Sugimachi K.
      Submitted (2001-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 10.
      "The DNA sequence and analysis of human chromosome 14."
      Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
      Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Choriocarcinoma.
      tissue: Placenta.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN COMPLEX WITH EP300 AND CREBBP;INTERACTION WITH EP300
    13. 13.
      "Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension."
      Jiang B.H. , Zheng J.Z. , Leung S.W. , Roe R. , Semenza G.L.
      J. Biol. Chem.272:19253-19260(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSACTIVATION DOMAINS NTAD AND CTAD
    14. 14.
      "Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha."
      Kallio P.J. , Okamoto K. , O'Brien S. , Carrero P. , Makino Y. , Tanaka H. , Poellinger L.
      EMBO J.17:6573-6586(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-719
    15. 15.
      "Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway."
      Huang L.E. , Gu J. , Schau M. , Bunn H.F.
      Proc. Natl. Acad. Sci. U.S.A.95:7987-7992(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: OXYGEN-DEPENDENT DEGRADATION DOMAIN
    16. 16.
      "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300."
      Ema M. , Hirota K. , Mimura J. , Abe H. , Yodoi J. , Sogawa K. , Poellinger L. , Fujii-Kuriyama Y.
      EMBO J.18:1905-1914(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TRANSACTIVATION DOMAINS NTAD AND CTAD;INTERACTION WITH APEX;MUTAGENESIS OF CYS-800
    17. 17.
      "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1."
      Bhattacharya S. , Michels C.M. , Leung M.K. , Arany Z.P. , Kung A.L. , Livingston D.M.
      Genes Dev.13:64-75(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DNA-BINDING;INTERACTION WITH EP300
    18. 18.
      "Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity."
      Aso T. , Yamazaki K. , Aigaki T. , Kitajima S.
      Biochem. Biophys. Res. Commun.276:355-361(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VHL
    19. 19.
      "Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein."
      Tanimoto K. , Makino Y. , Pereira T. , Poellinger L.
      EMBO J.19:4298-4309(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VHL AND ARNT;MUTAGENESIS OF LYS-532; LYS-538; LYS-547 AND LYS-719
    20. 20.
      "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha."
      Carrero P. , Okamoto K. , Coumailleau P. , O'Brien S. , Tanaka H. , Poellinger L.
      Mol. Cell. Biol.20:402-415(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOA1; NCOA2 AND APEX
    21. 21.
      "Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations."
      Sutter C.H. , Laughner E. , Semenza G.L.
      Proc. Natl. Acad. Sci. U.S.A.97:4748-4753(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-551 AND THR-552;UBIQUITINATION
    22. 22.
      "Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation."
      Masson N. , Willam C. , Maxwell P.H. , Pugh C.W. , Ratcliffe P.J.
      EMBO J.20:5197-5206(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION AT PRO-402 AND PRO-564;UBIQUITINATION;INTERACTION WITH THE VHLE COMPLEX;FUNCTION;MUTAGENESIS OF PRO-394; LEU-397; LEU-400; PRO-402 AND PRO-564
    23. 23.
      "Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7."
      Cho S. , Choi Y.J. , Kim J.M. , Jeong S.T. , Kim J.H. , Kim S.H. , Ryu S.E.
      FEBS Lett.498:62-66(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMA7
    24. 24.
      "Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation."
      Jaakkola P. , Mole D.R. , Tian Y.-M. , Wilson M.I. , Gielbert J. , Gaskell S.J. , von Kriegsheim A. , Hebestreit H.F. , Mukherji M. , Schofield C.J. , Maxwell P.H. , Pugh C.W. , Ratcliffe P.J.
      Science292:468-472(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;FUNCTION;HYDROXYLATION AT PRO-564
    25. 25.
      "Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation."
      Jeong J.-W. , Bae M.-K. , Ahn M.-Y. , Kim S.-H. , Sohn T.-K. , Bae M.-H. , Yoo M.-A. , Song E.-J. , Lee K.-J. , Kim K.-W.
      Cell111:709-720(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARD1A
    26. 26.
      "FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor."
      Lando D. , Peet D.J. , Gorman J.J. , Whelan D.A. , Whitelaw M.L. , Bruick R.K.
      Genes Dev.16:1466-1471(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION AT ASN-803;IDENTIFICATION BY MASS SPECTROMETRY
    27. 27.
      "Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor."
      Ivan M. , Haberberger T. , Gervasi D.C. , Michelson K.S. , Guenzler V. , Kondo K. , Yang H. , Sorokina I. , Conaway R.C. , Conaway J.W. , Kaelin W.G. Jr.
      Proc. Natl. Acad. Sci. U.S.A.99:13459-13464(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HYDROXYLATION AT PRO-564;IDENTIFICATION BY MASS SPECTROMETRY
    28. 28.
      "S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity."
      Yasinska I.M. , Sumbayev V.V.
      FEBS Lett.549:105-109(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-800;MUTAGENESIS OF CYS-800
    29. 29.
      "HIF-1 alpha protein as a target for S-nitrosation."
      Sumbayev V.V. , Budde A. , Zhou J. , Bruene B.
      FEBS Lett.535:106-112(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION
    30. 30.
      "Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2."
      Freedman S.J. , Sun Z.Y. , Kung A.L. , France D.S. , Wagner G. , Eck M.J.
      Nat. Struct. Biol.10:504-512(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EP300;MUTAGENESIS OF LEU-795
    31. 31.
      "Sumoylation increases HIF-1alpha stability and its transcriptional activity."
      Bae S.-H. , Jeong J.-W. , Park J.A. , Kim S.-H. , Bae M.-K. , Choi S.-J. , Kim K.-W.
      Biochem. Biophys. Res. Commun.324:394-400(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-391 AND LYS-477;FUNCTION;MUTAGENESIS OF LYS-389; LYS-391; LYS-392; LYS-442; LYS-460; LYS-477; LYS-532; LYS-538 AND LYS-547
    32. 32.
      "Molecular cloning and characterization of the von Hippel-Lindau-like protein."
      Qi H. , Gervais M.L. , Li W. , DeCaprio J.A. , Challis J.R.G. , Ohh M.
      Mol. Cancer Res.2:43-52(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VHLL
    33. 33.
      "VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha."
      Li Z. , Wang D. , Messing E.M. , Wu G.
      EMBO Rep.6:373-378(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP20;INTERACTION WITH USP20
    34. 34.
      "Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha."
      Arnesen T. , Kong X. , Evjenth R. , Gromyko D. , Varhaug J.E. , Lin Z. , Sang N. , Caro J. , Lillehaug J.R.
      FEBS Lett.579:6428-6432(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARD1A;MUTAGENESIS OF LYS-532
    35. 35.
      "Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha."
      Fath D.M. , Kong X. , Liang D. , Lin Z. , Chou A. , Jiang Y. , Fang J. , Caro J. , Sang N.
      J. Biol. Chem.281:13612-13619(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EP300 IN THE HIF1A/EP300/CREBBP COMPLEX;MUTAGENESIS OF ASN-803
    36. 36.
      "Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells."
      Choi S.M. , Choi K.-O. , Park Y.K. , Cho H. , Yang E.G. , Park H.
      J. Biol. Chem.281:34056-34063(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;HYDROXYLATION;FUNCTION;INTERACTION WITH CBPP;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF ASN-803
    37. 37.
      "SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity."
      Berta M.A. , Mazure N. , Hattab M. , Pouyssegur J. , Brahimi-Horn M.C.
      Biochem. Biophys. Res. Commun.360:646-652(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-391 AND LYS-477;FUNCTION;MUTAGENESIS OF LYS-377; LYS-391; LYS-477 AND LYS-532
    38. 38.
      "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia."
      Carbia-Nagashima A. , Gerez J. , Perez-Castro C. , Paez-Pereda M. , Silberstein S. , Stalla G.K. , Holsboer F. , Arzt E.
      Cell131:309-323(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;INTERACTION WITH RWDD3
    39. 39.
      "RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha."
      Liu Y.V. , Baek J.H. , Zhang H. , Diez R. , Cole R.N. , Semenza G.L.
      Mol. Cell25:207-217(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
    40. 40.
      "HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases."
      Paltoglou S. , Roberts B.J.
      Oncogene26:604-609(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION AT LYS-532; LYS-538 AND LYS-547;INTERACTION WITH VHL;MUTAGENESIS OF PRO-402; LYS-532; LYS-538; LYS-547 AND PRO-564
    41. 41.
      "Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling."
      Kim E.J. , Yoo Y.G. , Yang W.K. , Lim Y.S. , Na T.Y. , Lee I.K. , Lee M.O.
      Arterioscler. Thromb. Vasc. Biol.28:1796-1802(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RORA
    42. 42.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON REGULATION
    43. 43.
      "Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth."
      Nardinocchi L. , Puca R. , Guidolin D. , Belloni A.S. , Bossi G. , Michiels C. , Sacchi A. , Onisto M. , D'Orazi G.
      Biochim. Biophys. Acta1793:368-377(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY HIPK2
    44. 44.
      "HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport."
      Li Y. , Lim S. , Hoffman D. , Aspenstrom P. , Federoff H.J. , Rempe D.A.
      J. Cell Biol.185:1065-1081(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOCHONDRIAL TRANSPORT
    45. 45.
      "Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1."
      Gimm T. , Wiese M. , Teschemacher B. , Deggerich A. , Schodel J. , Knaup K.X. , Hackenbeck T. , Hellerbrand C. , Amann K. , Wiesener M.S. , Honing S. , Eckardt K.U. , Warnecke C.
      FASEB J.24:4443-4458(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    46. 46.
      "Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha."
      Xu D. , Yao Y. , Lu L. , Costa M. , Dai W.
      J. Biol. Chem.285:38944-38950(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-551; THR-555; SER-576; SER-589 AND SER-657;MUTAGENESIS OF SER-576 AND SER-657
    47. 47.
      "Casein kinase 1 regulates human hypoxia-inducible factor HIF-1."
      Kalousi A. , Mylonis I. , Politou A.S. , Chachami G. , Paraskeva E. , Simos G.
      J. Cell Sci.123:2976-2986(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-247 BY CSNK1D/CK1;MUTAGENESIS OF SER-247;INTERACTION WITH ARNT
    48. 48.
      "UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1alpha accumulation."
      Bandau S. , Knebel A. , Gage Z.O. , Wood N.T. , Alexandru G.
      BMC Biol.10:36-36(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
    49. 49.
      "Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia."
      Altun M. , Zhao B. , Velasco K. , Liu H. , Hassink G. , Paschke J. , Pereira T. , Lindsten K.
      J. Biol. Chem.287:1962-1969(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP19
    50. 50.
      "The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity."
      Foxler D.E. , Bridge K.S. , James V. , Webb T.M. , Mee M. , Wong S.C. , Feng Y. , Constantin-Teodosiu D. , Petursdottir T.E. , Bjornsson J. , Ingvarsson S. , Ratcliffe P.J. , Longmore G.D. , Sharp T.V.
      Nat. Cell Biol.14:201-208(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    51. 51.
      "In silico structural and functional characterization of the RSUME splice variants."
      Gerez J. , Fuertes M. , Tedesco L. , Silberstein S. , Sevlever G. , Paez-Pereda M. , Holsboer F. , Turjanski A.G. , Arzt E.
      PLoS ONE8:E57795-E57795(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RWDD3
    52. 52.
      "SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation."
      Seo K.S. , Park J.H. , Heo J.Y. , Jing K. , Han J. , Min K.N. , Kim C. , Koh G.Y. , Lim K. , Kang G.Y. , Uee Lee J. , Yim Y.H. , Shong M. , Kwak T.H. , Kweon G.R.
      Oncogene0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION;DEACETYLATION AT LYS-709 BY SIRT2;HYDROXYLATION;INTERACTION WITH SIRT2 AND EGLN1;MUTAGENESIS OF PRO-402; PRO-564 AND LYS-709
    53. 53.
      "A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence."
      Michel G. , Minet E. , Ernest I. , Roland I. , Durant F. , Remacle J. , Michiels C.
      J. Biomol. Struct. Dyn.18:169-179(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    54. 54.
      "Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha."
      Elkins J.M. , Hewitson K.S. , McNeill L.A. , Seibel J.F. , Schlemminger I. , Pugh C.W. , Ratcliffe P.J. , Schofield C.J.
      J. Biol. Chem.278:1802-1806(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 775-826 IN COMPLEX WITH HIF1AN
    55. 55.
      "Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha."
      Freedman S.J. , Sun Z.-Y.J. , Poy F. , Kung A.L. , Livingston D.M. , Wagner G. , Eck M.J.
      Proc. Natl. Acad. Sci. U.S.A.99:5367-5372(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 786-826 IN COMPLEX WITH 302-418 OF EP300
    56. 56.
      "Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response."
      Dames S.A. , Martinez-Yamout M. , De Guzman R.N. , Dyson H.J. , Wright P.E.
      Proc. Natl. Acad. Sci. U.S.A.99:5271-5276(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 776-826 IN COMPLEX WITH 345-439 OF CREBBP
    57. 57.
      "Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."
      Min J.-H. , Yang H. , Ivan M. , Gertler F. , Kaelin W.G. Jr. , Pavletich N.P.
      Science296:1886-1889(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 556-575 IN COMPLEX WITH TCEB1; TCEB2 AND 54-213 OF VHL
    58. 58.
      "Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL."
      Hon W.-C. , Wilson M.I. , Harlos K. , Claridge T.D.W. , Schofield C.J. , Pugh C.W. , Maxwell P.H. , Ratcliffe P.J. , Stuart D.I. , Jones E.Y.
      Nature417:975-978(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 549-582 IN COMPLEX WITH 17-112 OF TCEB1; TCEB2 AND 52-213 OF VHL
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