Histatin-3 (Protein name
), HIS3_HUMAN from NCBI database.
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Gene name:
HTN3(HIS2);
Protein name:
Histatin-3;
Alternative:
Histidine-rich protein 3;Basic histidine-rich protein(Hst);PB;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Histatin-3 1/24 is a homodimer. Histatin-3 and histatin-3 1/24 5 interact with yeast SSA1 and SSA2 proteins.
Function:
Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities. Histatin-3 1/24 (histatin-5) is especially effective against C.albicans and C.neoformans, and inhibits Lys-gingipain and Arg-gingipain (rgpB) from P.gingivalis. In addition, histatin-3 1/24 is a potent inhibitor of metalloproteinases MMP2 and MMP9.
Subcellular Location:
Secreted
Secreted by serous acinar and demilune cells.
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-51;VARIANTS HISTATIN-3-2 GLN-41 AND 47-TYR--ASN-51 DEL
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Cited for: PROTEIN SEQUENCE OF 20-32;IDENTIFICATION BY MASS SPECTROMETRY OF 24 PEPTIDE FRAGMENTS
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Cited for: FUNCTION;MUTAGENESIS OF ARG-31; LYS-32; LYS-36; HIS-38; HIS-40 AND ARG-41
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Cited for: LACK OF SULFATION AT TYR-43; TYR-47 AND TYR-49;IDENTIFICATION BY MASS SPECTROMETRY