HMGCR ELISA Kit for Human(Homo sapiens) | EIAab.comHMGCR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HMGCR(Gene name) > Human

HMGCR (Gene name),

3-hydroxy-3-methylglutaryl-coenzyme A reductase (Protein name ), HMDH_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

HMGCR;

Protein name:

3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMG-CoA reductase);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Peroxisome membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

888

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

888:

LSLMAALAAG | HLVKSHMIHN | RSKINLQDLQ | GACTKKTA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.628096

SMR:

P04035

Pfam:

PF00368

KEGG:

hsa:3156

String:

P04035

MIM:

142910

STRING:

9606.ENSP00000287936

Uniprot:

P04035

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ELISA Kit for Human HMG-CoA reductase

Cat.:

E10451h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Human HMG-CoA reductase

Cat.:

E10451r

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Manual:

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96T

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ELISA Kit for Human HMG-CoA reductase

MSDS:

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ELISA Kit for Human HMG-CoA reductase

MSDS:

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ELISA Kit for Human HMG-CoA reductase

Cat.:

E10451m

Price:

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Manual:

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96T

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ELISA Kit for Human HMG-CoA reductase

MSDS:

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CLIA Kit for Human HMG-CoA reductase

MSDS:

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CLIA Kit for Human HMG-CoA reductase

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CLIA Kit for Human HMG-CoA reductase

MSDS:

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CLIA Kit for Human HMG-CoA reductase

Cat.:

U10451r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human HMG-CoA reductase

Cat.:

U10451h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human HMG-CoA reductase

Cat.:

U10451m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human HMG-CoA reductase

Cat.:

P10451Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human HMG-CoA reductase

Monoclonal Antibody for Human HMG-CoA reductase

Protein for Human HMG-CoA reductase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation."
Luskey K.L. , Stevens B.
J. Biol. Chem.260:10271-10277(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Human HMG-CoA reductase gene."
Nakajima T. , Iwaki K. , Hamakubo T. , Kodama T. , Emi M.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Rieder M.J. , da Ponte S.H. , Kuldanek S.A. , Rajkumar N. , Smith J.D. , Toth E.J. , Nickerson D.A.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Thalamus.
5.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Blood.
7.

"Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth."
Brown M.S. , Goldstein J.L.
J. Lipid Res.21:505-517(1980) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
8.

"Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain."
Sever N. , Yang T. , Brown M.S. , Goldstein J.L. , DeBose-Boyd R.A.
Mol. Cell11:25-33(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSIG1;UBIQUITINATION
9.

"Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation."
Leichner G.S. , Avner R. , Harats D. , Roitelman J.
Mol. Biol. Cell20:3330-3341(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSIG1;UBIQUITINATION AT LYS-89 AND LYS-248;GLYCOSYLATION;MUTAGENESIS OF 75-TYR--TYR-77; LYS-89 AND LYS-248
10.

"Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein."
Leichner G.S. , Avner R. , Harats D. , Roitelman J.
J. Biol. Chem.286:32150-32161(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
11.

"A novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) splice variant with an alternative exon 1 potentially encoding an extended N-terminus."
Stormo C. , Kringen M.K. , Grimholt R.M. , Berg J.P. , Piehler A.P.
BMC Mol. Biol.13:29-29(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY (ISOFORM 3);ALTERNATIVE SPLICING
12.

"The UBIAD1 prenyltransferase links menaquione-4 synthesis to cholesterol metabolic enzymes."
Nickerson M.L. , Bosley A.D. , Weiss J.S. , Kostiha B.N. , Hirota Y. , Brandt W. , Esposito D. , Kinoshita S. , Wessjohann L. , Morham S.G. , Andresson T. , Kruth H.S. , Okano T. , Dean M.
Hum. Mutat.34:317-329(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBIAD1
13.

"Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis."
Istvan E.S. , Palnitkar M. , Buchanan S.K. , Deisenhofer J.
EMBO J.19:819-830(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 422-888;SUBUNIT
14.

"Structural mechanism for statin inhibition of HMG-CoA reductase."
Istvan E.S. , Deisenhofer J.
Science292:1160-1164(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 426-888
15.

"Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase."
Sarver R.W. , Bills E. , Bolton G. , Bratton L.D. , Caspers N.L. , Dunbar J.B. , Harris M.S. , Hutchings R.H. , Kennedy R.M. , Larsen S.D. , Pavlovsky A. , Pfefferkorn J.A. , Bainbridge G.
J. Med. Chem.51:3804-3813(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 441-875 IN COMPLEX WITH STATIN-BASED INHIBITORS
16.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-638
17.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM

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