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Index > Protein center > MR1(Gene name) > Human
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  • MR1 (Gene name),
  • Major histocompatibility complex class I-related gene protein (Protein name ),  HMR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MR1;
    Protein name:
    Major histocompatibility complex class I-related gene protein(MHC class I-related gene protein);
    Alternative:
    Class I histocompatibility antigen-like protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3.
    Function:
    Has antigen presentation function. Involved in the development and expansion of a small population of T cells expressing an invariant T cell receptor alpha chain called mucosal-associated invariant T cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therfore may be involed in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.
    Subcellular Location:
    Isoform 4 Secreted
    Protein Attributes:
    Sequence length:
    341
    Sequence:
    50:
    MGELMAFLLP | LIIVLMVKHS | DSRTHSLRYF | RLGVSDPIHG | VPEFISVGYV | 
    100:
    DSHPITTYDS | VTRQKEPRAP | WMAENLAPDH | WERYTQLLRG | WQQMFKVELK | 
    150:
    RLQRHYNHSG | SHTYQRMIGC | ELLEDGSTTG | FLQYAYDGQD | FLIFNKDTLS | 
    200:
    WLAVDNVAHT | IKQAWEANQH | ELLYQKNWLE | EECIAWLKRF | LEYGKDTLQR | 
    250:
    TEPPLVRVNR | KETFPGVTAL | FCKAHGFYPP | EIYMTWMKNG | EEIVQEIDYG | 
    300:
    DILPSGDGTY | QAWASIELDP | QSSNLYSCHV | EHCGVHMVLQ | VPQESETIPL | 
    341:
    VMKAVSGSIV | LVIVLAGVGV | LVWRRRPREQ | NGAIYLPTPD | R
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human MHC class I-related gene protein
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    E0910h
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    96T
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    ELISA Kit for Human MHC class I-related gene protein
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    E0910m
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    96T
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    ELISA Kit for Human MHC class I-related gene protein
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    E0910r
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    ELISA Kit for Human MHC class I-related gene protein
    Cat.:
    E0910b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MHC class I-related gene protein
    Cat.:
    U0910h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MHC class I-related gene protein
    Cat.:
    U0910b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MHC class I-related gene protein
    Cat.:
    U0910r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human MHC class I-related gene protein
    Cat.:
    U0910m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human MHC class I-related gene protein
    Polyclonal Antibody for Human MHC class I-related gene protein
    Cat.:
    P0910Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MHC class I-related gene protein
    Cat.:
    P0910Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human MHC class I-related gene protein
    Cat.:
    P0910Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human MHC class I-related gene protein
    Monoclonal Antibody for Human MHC class I-related gene protein
    Monoclonal Antibody for Human MHC class I-related gene protein
    Monoclonal Antibody for Human MHC class I-related gene protein
    Protein for Human MHC class I-related gene protein
    Protein for Human MHC class I-related gene protein
    Protein for Human MHC class I-related gene protein
    Protein for Human MHC class I-related gene protein

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    Linearity
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    References
    1. 1.
      "A gene outside the human MHC related to classical HLA class I genes."
      Hashimoto K. , Hirai M. , Kurosawa Y.
      Science269:693-695(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;TOPOLOGY
      tissue: Thymus.
    2. 2.
      "A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene."
      Parra-Cuadrado J.F. , Navarro P. , Mirones I. , Setien F. , Oteo M. , Martinez-Naves E.
      Tissue Antigens56:170-172(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);POLYMORPHISM
      tissue: Peripheral blood.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5)
      tissue: Tongue.
      tissue: Uterus.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney proximal tubule.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    8. 8.
      "Genomics, isoforms, expression, and phylogeny of the MHC class I-related MR1 gene."
      Riegert P. , Wanner V. , Bahram S.
      J. Immunol.161:4066-4077(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11;NUCLEOTIDE SEQUENCE [MRNA] OF 5-341 (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 6-229 (ISOFORM 4);TOPOLOGY;ALTERNATIVE SPLICING
    9. 9.
      "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog."
      Yamaguchi H. , Kurosawa Y. , Hashimoto K.
      Biochem. Biophys. Res. Commun.250:558-564(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 8-341
      tissue: Placenta.
    10. 10.
      "Unrelated expression patterns of MHC class Ia, Ib and TCRA molecules."
      Han M. , Robinson M.A.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-109;VARIANT ARG-39
    11. 11.
      "Biochemical features of the MHC-related protein 1 consistent with an immunological function."
      Miley M.J. , Truscott S.M. , Yu Y.Y. , Gilfillan S. , Fremont D.H. , Hansen T.H. , Lybarger L.
      J. Immunol.170:6090-6098(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SIGNAL SEQUENCE CLEAVAGE SITE;GLYCOSYLATION AT ASN-107;INTERACTION WITH B2M; TAPBP; CALR AND PDIA3;MUTAGENESIS OF CYS-283
    12. 12.
      "Novel MHC class I-related molecule MR1 affects MHC class I expression in 293T cells."
      Aldemir H.
      Biochem. Biophys. Res. Commun.366:328-334(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH B2M
    13. 13.
      "MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution."
      Huang S. , Martin E. , Kim S. , Yu L. , Soudais C. , Fremont D.H. , Lantz O. , Hansen T.H.
      Proc. Natl. Acad. Sci. U.S.A.106:8290-8295(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF GLN-169
    14. 14.
      "MR1B, a natural spliced isoform of the MHC-related 1 protein, is expressed as homodimers at the cell surface and activates MAIT cells."
      Lion J. , Debuysscher V. , Wlodarczyk A. , Hodroge A. , Serriari N.E. , Choteau L. , Ouled-haddou H. , Plistat M. , Lassoued K. , Lantz O. , Treiner E.
      Eur. J. Immunol.43:1363-1373(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION (ISOFORM 3);SUBUNIT (ISOFORM 3)
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-292 IN COMPLEX WITH VITAMIN B9 METABOLITE;LIGAND-BINDING SITES;DISULFIDE BONDS
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