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Index > Protein center > HNRNPF(Gene name) > Human
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  • HNRNPF (Gene name),
  • Heterogeneous nuclear ribonucleoprotein F (Protein name ),  HNRPF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HNRNPF(HNRPF);
    Protein name:
    Heterogeneous nuclear ribonucleoprotein F(hnRNP F);
    Alternative:
    Nucleolin-like protein mcs94-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Identified in the spliceosome C complex. Interacts with EIF2C1, EIF2C2, TBP and TXNL4/DIM1.
    Function:
    Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state.
    Subcellular Location:
    Nucleus nucleoplasm
    Protein Attributes:
    Sequence length:
    415
    Sequence:
    50:
    MMLGPEGGEG | FVVKLRGLPW | SCSVEDVQNF | LSDCTIHDGA | AGVHFIYTRE | 
    100:
    GRQSGEAFVE | LGSEDDVKMA | LKKDRESMGH | RYIEVFKSHR | TEMDWVLKHS | 
    150:
    GPNSADSAND | GFVRLRGLPF | GCTKEEIVQF | FSGLEIVPNG | ITLPVDPEGK | 
    200:
    ITGEAFVQFA | SQELAEKALG | KHKERIGHRY | IEVFKSSQEE | VRSYSDPPLK | 
    250:
    FMSVQRPGPY | DRPGTARRYI | GIVKQAGLER | MRPGAYSTGY | GGYEEYSGLS | 
    300:
    DGYGFTTDLF | GRDLSYCLSG | MYDHRYGDSE | FTVQSTTGHC | VHMRGLPYKA | 
    350:
    TENDIYNFFS | PLNPVRVHIE | IGPDGRVTGE | ADVEFATHEE | AVAAMSKDRA | 
    400:
    NMQHRYIELF | LNSTTGASNG | AYSSQVMQGM | GVSAAQATYS | GLESQSVSGC | 
    415:
    YGAGYSGQNS | MGGYD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human hnRNP F
    MSDS:
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    ELISA Kit for Human hnRNP F
    Cat.:
    E11569h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human hnRNP F
    Cat.:
    E11569m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human hnRNP F
    Cat.:
    E11569r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human hnRNP F
    Cat.:
    U11569h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human hnRNP F
    MSDS:
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    CLIA Kit for Human hnRNP F
    Cat.:
    U11569r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human hnRNP F
    Cat.:
    U11569m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human hnRNP F
    Cat.:
    P11569Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hnRNP F
    Polyclonal Antibody for Human hnRNP F
    Polyclonal Antibody for Human hnRNP F
    Monoclonal Antibody for Human hnRNP F
    Monoclonal Antibody for Human hnRNP F
    Monoclonal Antibody for Human hnRNP F
    Monoclonal Antibody for Human hnRNP F
    Protein for Human hnRNP F
    Protein for Human hnRNP F
    Protein for Human hnRNP F
    Protein for Human hnRNP F

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization."
      Matunis M.J. , Xing J. , Dreyfuss G.
      Nucleic Acids Res.22:1059-1067(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 52-61; 78-83 AND 128-136
    2. 2.
      "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes."
      Honore B. , Rasmussen H.H. , Vorum H. , Dejgaard K. , Liu X. , Gromov P. , Madsen P. , Gesser B. , Tommerup N. , Celis J.E.
      J. Biol. Chem.270:28780-28789(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    3. 3.
      "Identification and characterization of a gene at D10S94 in the MEN2A region."
      McDonald H. , Smailus D. , Jenkins H. , Adams K. , Simpson N.E. , Goodfellow P.J.
      Genomics13:344-348(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ARG-87
      tissue: Bone marrow.
      tissue: Lung.
      tissue: Ovary.
      tissue: Placenta.
      tissue: Uterus.
    8. 8.
      Bienvenut W.V. , Zebisch A. , Kolch W.
      Submitted (2008-10) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-14; 53-68; 82-87; 99-114; 151-167; 180-185 AND 300-347;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT MET-1 AND MET-2;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
      tissue: Colon carcinoma.
    9. 9.
      "Evidence that Dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for Dim1 interactions with hnRNP F and Npw38/PQBP-1."
      Zhang Y.-Z. , Lindblom T. , Chang A. , Sudol M. , Sluder A.E. , Golemis E.A.
      Gene257:33-43(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TXNL4
    10. 10.
      "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S. , Licklider L.J. , Gygi S.P. , Grigorieff N. , Moore M.J.
      RNA8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
    11. 11.
      "Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis."
      Li T. , Evdokimov E. , Shen R.F. , Chao C.C. , Tekle E. , Wang T. , Stadtman E.R. , Yang D.C. , Chock P.B.
      Proc. Natl. Acad. Sci. U.S.A.101:8551-8556(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-72
    12. 12.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells."
      Hoeck J. , Weinmann L. , Ender C. , Ruedel S. , Kremmer E. , Raabe M. , Urlaub H. , Meister G.
      EMBO Rep.8:1052-1060(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGO1 AND AGO2
    14. 14.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    15. 15.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND MET-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-224;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND SER-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND MET-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition."
      Dominguez C. , Allain F.H.
      Nucleic Acids Res.34:3634-3645(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-102; 103-194 AND 277-381 IN COMPLEX WITH BCL-X RNA;MUTAGENESIS OF PHE-120; PHE-156; HIS-178 AND TYR-180
    24. 24.
      "Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs."
      Dominguez C. , Fisette J.F. , Chabot B. , Allain F.H.
      Nat. Struct. Mol. Biol.17:853-861(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-194 AND 277-381 IN COMPLEXES WITH AGGGAU RNA OLIGONUCLEOTIDE;FUNCTION;MUTAGENESIS OF TRP-20; GLU-84; ARG-116; PHE-120; LYS-150; LYS-173; ARG-179; TYR-180; GLU-182 AND PHE-184
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