HRG ELISA Kit for Human(Homo sapiens) | EIAab.comHRG ELISA Kit for Human(Homo sapiens)

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HRG (Gene name),

Histidine-rich glycoprotein (Protein name ), HRG_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

HRG;

Protein name:

Histidine-rich glycoprotein;

Alternative:

Histidine-proline-rich glycoprotein(HPRG);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts (via the HRR domain) with TPM1; the interaction appears to contribute to the antiangiogenic properties of the HRR domain. Interacts with THBS2; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Interacts with THBS1 (via the TSP type I repeats); the interaction blocks the antiangiogenic effect of THBS1 with CD3. Interacts with PLG (via its Kringle domains); the interaction tethers PLG to the cell surface and enhances its activation. Interacts with HPSE; the interaction is enhanced at acidic pH, partially inhibits binding of HPSE to cell surface receptors and modulates its enzymatic activity. Interacts (via the HRR domain) with TMP1; the interaction partially mediates the antiangiogenic properties of HRG. Interacts with kappa and lambda light chains of IgG molecules. Interacts with ATP5A1; the interaction occurs on the surface of T-cells and alters their cell morphology in concert with CONA. Binds IgG molecules containing kappa and lambda light chains and inhibits the formation of insoluble immunoglobulin complexes. Interacts with F12; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding to HRG, inhibits factor XII autoactivation and contact-initiated coagulation.

Function:

Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in an heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

525

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

525:

SESCPGKFKS | GFPQVSMFFT | HTFPK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1498

SMR:

P04196

KEGG:

hsa:3273

MIM:

142640

String:

P04196

STRING:

9606.ENSP00000232003

Pfam:

PF00031

Uniprot:

P04196

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ELISA Kit for Human Histidine-rich glycoprotein

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E2267h

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96T

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ELISA Kit for Human Histidine-rich glycoprotein

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E2267m

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96T

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ELISA Kit for Human Histidine-rich glycoprotein

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E2267r

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ELISA Kit for Human Histidine-rich glycoprotein

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ELISA Kit for Human Histidine-rich glycoprotein

Cat.:

E2267b

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96T

CLIA Kit for Human Histidine-rich glycoprotein

Cat.:

U2267r

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96T

CLIA Kit for Human Histidine-rich glycoprotein

Cat.:

U2267b

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96T

CLIA Kit for Human Histidine-rich glycoprotein

Cat.:

U2267h

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MSDS:

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Packing:

96T

CLIA Kit for Human Histidine-rich glycoprotein

Cat.:

U2267m

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96T

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CLIA Kit for Human Histidine-rich glycoprotein

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Polyclonal Antibody for Human Histidine-rich glycoprotein

Cat.:

P2267Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Histidine-rich glycoprotein

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P2267Rb-r

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Polyclonal Antibody for Human Histidine-rich glycoprotein

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P2267Rb-m

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Monoclonal Antibody for Human Histidine-rich glycoprotein

Protein for Human Histidine-rich glycoprotein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Amino acid sequence of human histidine-rich glycoprotein derived from the nucleotide sequence of its cDNA."
Koide T. , Foster D.C. , Yoshitake S. , Davie E.W.
Biochemistry25:2220-2225(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

Wakabayashi S. , Takahashi K. , Tokunaga F. , Koide T.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
5.

"Evidence for the absence of intron H of the histidine-rich glycoprotein (HRG) gene: genetic mapping and in situ localization of HRG to chromosome 3q28-q29."
Hennis B.C. , Frants R.R. , Bakker E. , Vossen R.H. , van der Poort E.W. , Blonden L.A. , Cox S. , Khan P.M. , Spurr N.K. , Kluft C.
Genomics19:195-197(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 214-247
6.

"Plasma protein map: an update by microsequencing."
Hughes G.J. , Frutiger S. , Paquet N. , Ravier F. , Pasquali C. , Sanchez J.-C. , James R. , Tissot J.-D. , Bjellqvist B. , Hochstrasser D.F.
Electrophoresis13:707-714(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-27
tissue: Plasma.
7.

"Human serum histidine-rich glycoprotein. I. Interactions with heme, metal ions and organic ligands."
Morgan W.T.
Biochim. Biophys. Acta535:319-333(1978) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEME- AND METAL-BINDING
8.

"Differential binding of histidine-rich glycoprotein (HRG) to human IgG subclasses and IgG molecules containing kappa and lambda light chains."
Gorgani N.N. , Parish C.R. , Altin J.G.
J. Biol. Chem.274:29633-29640(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IMMUNOGLOBULIN G SUBCLASSES
9.

"Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1."
Simantov R. , Febbraio M. , Crombie R. , Asch A.S. , Nachman R.L. , Silverstein R.L.
J. Clin. Invest.107:45-52(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THBS1;FUNCTION
10.

"Histidine-proline-rich glycoprotein has potent antiangiogenic activity mediated through the histidine-proline-rich domain."
Juarez J.C. , Guan X. , Shipulina N.V. , Plunkett M.L. , Parry G.C. , Shaw D.E. , Zhang J.C. , Rabbani S.A. , McCrae K.R. , Mazar A.P. , Morgan W.T. , Donate F.
Cancer Res.62:5344-5350(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF HIS/PRO-RICH DOMAIN
11.

"A fragment of histidine-rich glycoprotein is a potent inhibitor of tumor vascularization."
Olsson A.K. , Larsson H. , Dixelius J. , Johansson I. , Lee C. , Oellig C. , Bjork I. , Claesson-Welsh L.
Cancer Res.64:599-605(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A NEGATIVE REGULATOR OF ANGIOGENESIS;PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY
12.

"Peptides derived from the histidine-proline domain of the histidine-proline-rich glycoprotein bind to tropomyosin and have antiangiogenic and antitumor activities."
Donate F. , Juarez J.C. , Guan X. , Shipulina N.V. , Plunkett M.L. , Tel-Tsur Z. , Shaw D.E. , Morgan W.T. , Mazar A.P.
Cancer Res.64:5812-5817(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE HIS/PRO-RICH REGION;INTERACTION WITH TPM1
13.

"Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn2+ chelation."
Jones A.L. , Hulett M.D. , Parish C.R.
J. Biol. Chem.279:30114-30122(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARAN SULFATE-BINDING;METAL-BINDING
14.

"Plasminogen is tethered with high affinity to the cell surface by the plasma protein, histidine-rich glycoprotein."
Jones A.L. , Hulett M.D. , Altin J.G. , Hogg P. , Parish C.R.
J. Biol. Chem.279:38267-38276(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLG;FUNCTION
15.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-63; ASN-125 AND ASN-344
tissue: Plasma.
16.

"Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein."
Dixelius J. , Olsson A.K. , Thulin A. , Lee C. , Johansson I. , Claesson-Welsh L.
Cancer Res.66:2089-2097(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE HIS/PRO-RICH REGION AS A NEGATIVE REGULATOR OF ANGIOGENESIS
17.

"The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner."
Vanwildemeersch M. , Olsson A.K. , Gottfridsson E. , Claesson-Welsh L. , Lindahl U. , Spillmann D.
J. Biol. Chem.281:10298-10304(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE HIS/PRO-RICH REGION AS A NEGATIVE REGULATOR OF ANGIOGENESIS;COFACTOR;ZINC-BINDING;HEPARIN- AND HEPARAN SULFATE-BINDING
18.

"Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage."
Poon I.K. , Olsson A.K. , Hulett M.D. , Parish C.R.
Biochem. J.424:27-37(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;HEPARAN SULFATE-BINDING;INTERACTION WITH PLG;FUNCTION
19.

"High affinity interaction between histidine-rich glycoprotein and the cell surface type ATP synthase on T-cells."
Ohta T. , Ikemoto Y. , Usami A. , Koide T. , Wakabayashi S.
Biochim. Biophys. Acta1788:1099-1107(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATP5A1;FUNCTION;GLYCOSYLATION AT ASN-63;IDENTIFICATION BY MASS SPECTROMETRY
20.

"Histidine-rich glycoprotein and concanavalin A synergistically stimulate the phosphatidylinositol 3-kinase-independent signaling pathway in leukocytes leading to increased cell adhesion and changes in cell morphology."
Ohta T. , Ikemoto Y. , Saeki K. , Koide T. , Wakabayashi S.
Cell. Immunol.259:5-12(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Probing the Cu(2+) and Zn(2+) binding affinity of histidine-rich glycoprotein."
Jancso A. , Kolozsi A. , Gyurcsik B. , Nagy N.V. , Gajda T.
J. Inorg. Biochem.103:1634-1643(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METAL-BINDING
22.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-125
tissue: Liver.
23.

"Activated platelets provide a functional microenvironment for the antiangiogenic fragment of histidine-rich glycoprotein."
Thulin A. , Ringvall M. , Dimberg A. , Karehed K. , Vaisanen T. , Vaisanen M.R. , Hamad O. , Wang J. , Bjerkvig R. , Nilsson B. , Pihlajaniemi T. , Akerud H. , Pietras K. , Jahnen-Dechent W. , Siegbahn A. , Olsson A.K.
Mol. Cancer Res.7:1792-1802(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PROTEOLYTIC PROCESSING;IDENTIFICATION BY MASS SPECTROMETRY;TISSUE SPECIFICITY
24.

"Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions."
Poon I.K. , Yee D.Y. , Jones A.L. , Wood R.J. , Davis D.S. , Freeman C. , Parish C.R. , Hulett M.D.
Int. J. Biochem. Cell Biol.42:1507-1516(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HPSE
25.

"Histidine-rich glycoprotein functions cooperatively with cell surface heparan sulfate on phagocytes to promote necrotic cell uptake."
Poon I.K. , Parish C.R. , Hulett M.D.
J. Leukoc. Biol.88:559-569(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HEPARIN- AND HEPARAN SULFATE-BINDING
26.

"Histidine-rich glycoprotein binds factor XIIa with high affinity and inhibits contact-initiated coagulation."
Macquarrie J.L. , Stafford A.R. , Yau J.W. , Leslie B.A. , Vu T.T. , Fredenburgh J.C. , Weitz J.I.
Blood117:4134-4141(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH F12;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
27.

"HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF."
Rolny C. , Mazzone M. , Tugues S. , Laoui D. , Johansson I. , Coulon C. , Squadrito M.L. , Segura I. , Li X. , Knevels E. , Costa S. , Vinckier S. , Dresselaer T. , Akerud P. , De Mol M. , Salomaki H. , Phillipson M. , Wyns S. , more...
Cancer Cell19:31-44(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS A TUMOR SUPPRESSOR;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
28.

"HRG Tokushima: molecular and cellular characterization of histidine-rich glycoprotein (HRG) deficiency."
Shigekiyo T. , Yoshida H. , Matsumoto K. , Azuma H. , Wakabayashi S. , Saito S. , Fujikawa K. , Koide T.
Blood91:128-133(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH11 GLU-103;CHARACTERIZATION OF VARIANT THPH11 GLU-103
29.

"Histidine-rich glycoprotein (HRG) Tokushima 2: novel HRG deficiency, molecular and cellular characterization."
Shigekiyo T. , Yoshida H. , Kanagawa Y. , Satoh K. , Wakabayashi S. , Matsumoto T. , Koide T.
Thromb. Haemost.84:675-679(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THPH11 ARG-241;CHARACTERIZATION OF VARIANT THPH11 ARG-241

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