Protein name:
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) ;
Alternative:
Adaptor in lymphocytes of unknown function X ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with FES and TNK2.
Function:
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MTEAGKLPLP | LPPRLDWFVH | TQMGQLAQDG | VPEWFHGAIS | REDAENLLES |
100:
QPLGSFLIRV | SHSHVGYTLS | YKAQSSCCHF | MVKLLDDGTF | MIPGEKVAHT |
150:
SLDALVTFHQ | QKPIEPRREL | LTQPCRQKDP | ANVDYEDLFL | YSNAVAEEAA |
200:
CPVSAPEEAS | PKPVLCHQSK | ERKPSAEMNR | ITTKEATSSC | PPKSPLGETR |
250:
QKLWRSLKML | PERGQRVRQQ | LKSHLATVNL | SSLLDVRRST | VISGPGTGKG |
300:
SQDHSGDPTS | GDRGYTDPCV | ATSLKSPSQP | QAPKDRKVPT | RKAERSVSCI |
350:
EVTPGDRSWH | QMVVRALSSQ | ESKPEHQGLA | EPENDQLPEE | YQQPPPFAPG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Hematopoietic SH2 protein
ELISA Kit for Human Hematopoietic SH2 protein
CLIA Kit for Human Hematopoietic SH2 protein
CLIA Kit for Human Hematopoietic SH2 protein
Polyclonal Antibody for Human Hematopoietic SH2 protein
Polyclonal Antibody for Human Hematopoietic SH2 protein
Monoclonal Antibody for Human Hematopoietic SH2 protein
Monoclonal Antibody for Human Hematopoietic SH2 protein
Protein for Human Hematopoietic SH2 protein
Protein for Human Hematopoietic SH2 protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH FES AND TNK2;SUBCELLULAR LOCATION;PHOSPHORYLATION;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
B-cell .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF 10-PRO--PRO-13; PRO-116; TYR-135; 192-PRO--PRO-195; TYR-341 AND 346-PRO--PRO-349;FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 24-129