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Index > Protein center > HSH2D(Gene name) > Human
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  • HSH2D (Gene name),
  • Hematopoietic SH2 domain-containing protein (Protein name ),  HSH2D_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HSH2D(ALX);
    Protein name:
    Hematopoietic SH2 domain-containing protein(Hematopoietic SH2 protein);
    Alternative:
    Adaptor in lymphocytes of unknown function X;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FES and TNK2.
    Function:
    May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    352
    Sequence:
    50:
    MTEAGKLPLP | LPPRLDWFVH | TQMGQLAQDG | VPEWFHGAIS | REDAENLLES | 
    100:
    QPLGSFLIRV | SHSHVGYTLS | YKAQSSCCHF | MVKLLDDGTF | MIPGEKVAHT | 
    150:
    SLDALVTFHQ | QKPIEPRREL | LTQPCRQKDP | ANVDYEDLFL | YSNAVAEEAA | 
    200:
    CPVSAPEEAS | PKPVLCHQSK | ERKPSAEMNR | ITTKEATSSC | PPKSPLGETR | 
    250:
    QKLWRSLKML | PERGQRVRQQ | LKSHLATVNL | SSLLDVRRST | VISGPGTGKG | 
    300:
    SQDHSGDPTS | GDRGYTDPCV | ATSLKSPSQP | QAPKDRKVPT | RKAERSVSCI | 
    350:
    EVTPGDRSWH | QMVVRALSSQ | ESKPEHQGLA | EPENDQLPEE | YQQPPPFAPG | 
    352:
    YC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hematopoietic SH2 protein
    Cat.:
    E1205m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Hematopoietic SH2 protein
    Cat.:
    E1205h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Hematopoietic SH2 protein
    Cat.:
    U1205m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hematopoietic SH2 protein
    Cat.:
    U1205h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Hematopoietic SH2 protein
    Cat.:
    P1205Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hematopoietic SH2 protein
    Cat.:
    P1205Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Hematopoietic SH2 protein
    Monoclonal Antibody for Human Hematopoietic SH2 protein
    Protein for Human Hematopoietic SH2 protein
    Protein for Human Hematopoietic SH2 protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells."
      Oda T. , Muramatsu M.-A. , Isogai T. , Masuho Y. , Asano S. , Yamashita T.
      Biochem. Biophys. Res. Commun.288:1078-1086(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INTERACTION WITH FES AND TNK2;SUBCELLULAR LOCATION;PHOSPHORYLATION;FUNCTION
    2. 2.
      "Cloning and characterization of ALX, an adaptor downstream of CD28."
      Greene T.A. , Powell P. , Nzerem C. , Shapiro M.J. , Shapiro V.S.
      J. Biol. Chem.278:45128-45134(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;FUNCTION
      tissue: Spleen.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
      tissue: Urinary bladder.
    4. 4.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: B-cell.
    7. 7.
      "The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP."
      Shapiro M.J. , Powell P. , Ndubuizu A. , Nzerem C. , Shapiro V.S.
      J. Biol. Chem.279:40647-40652(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 10-PRO--PRO-13; PRO-116; TYR-135; 192-PRO--PRO-195; TYR-341 AND 346-PRO--PRO-349;FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
    8. 8.
      "The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation."
      Shapiro M.J. , Chen Y.-Y. , Shapiro V.S.
      J. Biol. Chem.280:38242-38246(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Solution structure of the SH2 domain of human HSH2D protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 24-129
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