GCK ELISA Kit for Human(Homo sapiens) | EIAab.comGCK ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GCK(Gene name) > Human

GCK (Gene name),

Glucokinase (Protein name ), HXK4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GCK;

Protein name:

Glucokinase;

Alternative:

Hexokinase-4(HK4);Hexokinase type IV(HK IV);Hexokinase-D;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

465

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

465:

LVSAVACKKA | CMLGQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00349

SMR:

P35557

MIM:

125851

UniGene:

Hs.1270

KEGG:

hsa:2645

String:

P35557

STRING:

9606.ENSP00000223366

Uniprot:

P35557

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ELISA Kit for Human Glucokinase

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E0667h

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96T

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ELISA Kit for Human Glucokinase

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E0667r

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96T

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ELISA Kit for Human Glucokinase

Cat.:

E0667m

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96T

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CLIA Kit for Human Glucokinase

Cat.:

U0667m

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96T

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CLIA Kit for Human Glucokinase

Cat.:

U0667h

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96T

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CLIA Kit for Human Glucokinase

Cat.:

U0667r

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Looking for manual.

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Packing:

96T

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Polyclonal Antibody for Human Glucokinase

Cat.:

P0667Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Glucokinase

Cat.:

P0667Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Glucokinase

Cat.:

P0667Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Glucokinase

Protein for Human Glucokinase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism."
Tanizawa Y. , Matsutani A. , Chiu K.C. , Permutt M.A.
Mol. Endocrinol.6:1070-1081(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs."
Tanizawa Y. , Koranyi L.I. , Welling C.M. , Permutt M.A.
Proc. Natl. Acad. Sci. U.S.A.88:7294-7297(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-107
3.

"Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p13."
Nishi S. , Stoffel M. , Xiang K.S. , Shows T.B. , Bell G.I. , Takeda J.
Diabetologia35:743-747(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Pancreas.
4.

"Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA."
Koranyi L.I. , Tanizawa Y. , Welling C.M. , Rabin D.U. , Permutt M.A.
Diabetes41:807-811(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Pancreas.
5.

"Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus."
Stoffel M. , Froguel P. , Takeda J. , Zouali H. , Vionnet N. , Nishi S. , Weber I.T. , Harrison R.W. , Pilkis S.J. , Lesage S. , Vaxillaire M. , Velho G. , Sun F. , Iris F. , Passa P. , Cohen D. , Bell G.I.
Proc. Natl. Acad. Sci. U.S.A.89:7698-7702(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MODY2 MET-228 AND ARG-261
tissue: Placenta.
6.

Stoffel M. , Froguel P. , Takeda J. , Zouali H. , Vionnet N. , Nishi S. , Weber I.T. , Harrison R.W. , Pilkis S.J. , Lesage S. , Vaxillaire M. , Velho G. , Sun F. , Iris F. , Passa P. , Cohen D. , Bell G.I.
Proc. Natl. Acad. Sci. U.S.A.89:10562-10562(1992)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
7.

"Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus."
Sakura H. , Eto K. , Kadowaki H. , Simokawa K. , Ueno H. , Koda N. , Fukushima Y. , Akanuma Y. , Yazaki Y. , Kadowaki T.
J. Clin. Endocrinol. Metab.75:1571-1573(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-107;VARIANT MODY2 ARG-261
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Liver.
9.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
12.

"Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase."
de la Iglesia N. , Veiga-da-Cunha M. , Van Schaftingen E. , Guinovart J.J. , Ferrer J.C.
FEBS Lett.456:332-338(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;SUBCELLULAR LOCATION
13.

"Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B."
St Charles R. , Harrison R.W. , Bell G.I. , Pilkis S.J. , Weber I.T.
Diabetes43:784-791(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
14.

"Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase."
Kamata K. , Mitsuya M. , Nishimura T. , Eiki J. , Nagata Y.
Structure12:429-438(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 16-465 OF APOPROTEIN AND IN COMPLEX WITH GLUCOSE;SUBUNIT;ENZYME REGULATION
15.

"Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators."
Mitsuya M. , Kamata K. , Bamba M. , Watanabe H. , Sasaki Y. , Sasaki K. , Ohyama S. , Hosaka H. , Nagata Y. , Eiki J. , Nishimura T.
Bioorg. Med. Chem. Lett.19:2718-2721(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 16-465 IN COMPLEX WITH SYNTHETIC ALLOSTERIC ACTIVATOR
16.

"Structural basis for regulation of human glucokinase by glucokinase regulatory protein."
Beck T. , Miller B.G.
Biochemistry52:6232-6239(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF 3-465 IN COMPLEX WITH RAT GKRP
17.

"Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes."
Stoffel M. , Patel P. , Lo Y.-M.D. , Hattersley A.T. , Lucassen A.M. , Page R. , Bell J.I. , Bell G.I. , Turner R.C. , Wainscoat J.S.
Nat. Genet.2:153-156(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MODY2 ARG-299
18.

"Glucokinase gene variants in the common form of NIDDM."
Chiu K.C. , Tanizawa Y. , Permutt M.A.
Diabetes42:579-582(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-11
19.

"Identification of glucokinase mutations in subjects with gestational diabetes mellitus."
Stoffel M. , Bell K.L. , Blackburn C.L. , Powell K.L. , Seo T.S. , Takeda J. , Vionnet N. , Xiang K.-S. , Gidh-Jain M. , Pilkis S.J. , Ober C. , Bell G.I.
Diabetes42:937-940(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MODY2 PRO-131
20.

"Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants."
Takeda J. , Gidh-Jain M. , Xu L.Z. , Froguel P. , Velho G. , Vaxillaire M. , Cohen D. , Shimada F. , Makino H. , Nishi S. , Stoffel M. , Vionnet N. , St Charles R. , Harrison R.W. , Weber I.T. , Bell G.I. , Pilkis S.J.
J. Biol. Chem.268:15200-15204(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-4;VARIANTS MODY2 LYS-70; PRO-131; THR-188; ARG-257 AND GLU-414
21.

"Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships."
Gidh-Jain M. , Takeda J. , Xu L.Z. , Lange A.J. , Vionnet N. , Stoffel M. , Froguel P. , Velho G. , Sun D. , Cohen D. , Patel P. , Lo Y.-M.D. , Hattersley A.T. , Luthman H. , Wedell A. , St Charles R. , Harrison R.W. , Weber I.T. , more...
Proc. Natl. Acad. Sci. U.S.A.90:1932-1936(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS MODY2
22.

"Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique."
Hager J. , Blanche H. , Sun F. , Vionnet N. , Vaxillaire M. , Poller W. , Cohen D. , Czernichow P. , Velho G. , Robert J.-J. , Cohen N. , Froguel P.
Diabetes43:730-733(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2 TRP-36; MET-209 AND GLU-261
23.

"Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families."
Velho G. , Blanche H. , Vaxillaire M. , Bellanne-Chantelot C. , Pardini V.C. , Timsit J. , Passa P. , Deschamps I. , Robert J.-J. , Weber I.T. , Marotta D. , Pilkis S.J. , Lipkind G.M. , Bell G.I. , Froguel P.
Diabetologia40:217-224(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2
24.

"Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY)."
Guazzini B. , Gaffi D. , Mainieri D. , Multari G. , Cordera R. , Bertolini S. , Pozza G. , Meschi F. , Barbetti F.
Hum. Mutat.12:136-136(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2 SER-80; LYS-221 AND CYS-227
25.

"Mutations in the glucokinase gene of the fetus result in reduced birth weight."
Hattersley A.T. , Beards F. , Ballantyne E. , Appleton M. , Harvey R. , Ellard S.
Nat. Genet.19:268-270(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2 HIS-108; SER-150; THR-259; ARG-299; TYR-382; THR-384 AND CYS-392
26.

"Familial hyperinsulinism caused by an activating glucokinase mutation."
Glaser B. , Kesavan P. , Heyman M. , Davis E. , Cuesta A. , Buchs A. , Stanley C.A. , Thornton P.S. , Permutt M.A. , Matschinsky F.M. , Herold K.C.
N. Engl. J. Med.338:226-230(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HHF3 MET-455
27.

"Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY."
Ng M.C.Y. , Cockburn B.N. , Lindner T.H. , Yeung V.T.F. , Chow C.-C. , So W.-Y. , Li J.K.Y. , Lo Y.M.D. , Lee Z.S.K. , Cockram C.S. , Critchley J.A.J.H. , Bell G.I. , Chan J.C.N.
Diabet. Med.16:956-963(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2 THR-110; ASP-119 AND VAL-385
28.

"Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus."
Nam J.H. , Lee H.C. , Kim Y.H. , Cha B.S. , Song Y.D. , Lim S.K. , Kim K.R. , Huh K.B.
Diabetes Res. Clin. Pract.50:169-176(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MODY2 PRO-164
29.

"Neonatal diabetes mellitus due to complete glucokinase deficiency."
Njoelstad P.R. , Soevik O. , Cuesta-Munoz A. , Bjoerkhaug L. , Massa O. , Barbetti F. , Undlien D.E. , Shiota C. , Magnuson M.A. , Molven A. , Matschinsky F.M. , Bell G.I.
N. Engl. J. Med.344:1588-1592(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY2 LYS-210 AND MET-228
30.

"The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY."
Steele A.M. , Tribble N.D. , Caswell R. , Wensley K.J. , Hattersley A.T. , Gloyn A.L. , Ellard S.
Diabetologia54:2202-2205(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-342

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