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Index > Protein center > HYAL1(Gene name) > Human
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  • HYAL1 (Gene name),
  • Hyaluronidase-1 (Protein name ),  HYAL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HYAL1(LUCA1);
    Protein name:
    Hyaluronidase-1(Hyal-1);
    Alternative:
    Lung carcinoma protein 1(LuCa-1);Hyaluronoglucosaminidase-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
    Subcellular Location:
    Secreted Lysosome
    Protein Attributes:
    Sequence length:
    435
    Sequence:
    50:
    MAAHLLPICA | LFLTLLDMAQ | GFRGPLLPNR | PFTTVWNANT | QWCLERHGVD | 
    100:
    VDVSVFDVVA | NPGQTFRGPD | MTIFYSSQLG | TYPYYTPTGE | PVFGGLPQNA | 
    150:
    SLIAHLARTF | QDILAAIPAP | DFSGLAVIDW | EAWRPRWAFN | WDTKDIYRQR | 
    200:
    SRALVQAQHP | DWPAPQVEAV | AQDQFQGAAR | AWMAGTLQLG | RALRPRGLWG | 
    250:
    FYGFPDCYNY | DFLSPNYTGQ | CPSGIRAQND | QLGWLWGQSR | ALYPSIYMPA | 
    300:
    VLEGTGKSQM | YVQHRVAEAF | RVAVAAGDPN | LPVLPYVQIF | YDTTNHFLPL | 
    350:
    DELEHSLGES | AAQGAAGVVL | WVSWENTRTK | ESCQAIKEYM | DTTLGPFILN | 
    400:
    VTSGALLCSQ | ALCSGHGRCV | RRTSHPKALL | LLNPASFSIQ | LTPGGGPLSL | 
    435:
    RGALSLEDQA | QMAVEFKCRC | YPGWQAPWCE | RKSMW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    Pfam:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hyal-1
    Cat.:
    E1217h
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    Packing:
    96T
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    ELISA Kit for Human Hyal-1
    Cat.:
    E1217b
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    Packing:
    96T
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    ELISA Kit for Human Hyal-1
    Cat.:
    E1217p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Hyal-1
    Cat.:
    E1217m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Hyal-1
    Cat.:
    E1217r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Hyal-1
    Cat.:
    U1217r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Hyal-1
    Cat.:
    U1217p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-1
    Cat.:
    U1217m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-1
    Cat.:
    U1217b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Hyal-1
    Cat.:
    U1217h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Hyal-1
    Cat.:
    P1217Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hyal-1
    Cat.:
    P1217Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hyal-1
    Polyclonal Antibody for Human Hyal-1
    Cat.:
    P1217Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Hyal-1
    Monoclonal Antibody for Human Hyal-1
    Monoclonal Antibody for Human Hyal-1
    Monoclonal Antibody for Human Hyal-1
    Monoclonal Antibody for Human Hyal-1
    Monoclonal Antibody for Human Hyal-1
    Protein for Human Hyal-1
    Protein for Human Hyal-1
    Protein for Human Hyal-1
    Protein for Human Hyal-1
    Protein for Human Hyal-1

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG."
      Wei M.H. , Latif F. , Bader S. , Kashuba V. , Chen J.Y. , Duh F.-M. , Sekido Y. , Lee C.C. , Geil L. , Kuzmin I. , Zabarovsky E. , Klein G. , Zbar B. , Minna J.D. , Lerman M.I.
      Cancer Res.56:1487-1492(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Heart.
      tissue: Lung cancer.
    2. 2.
      "Purification, cloning, and expression of human plasma hyaluronidase."
      Frost G.I. , Csoka A.B. , Wong T. , Stern R.
      Biochem. Biophys. Res. Commun.236:10-15(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 22-37; 72-84; 248-259 AND 261-273;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Plasma.
    3. 3.
      "HYAL1(LUCA-1), a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA."
      Frost G.I. , Mohapatra G. , Wong T.M. , Csoka A.B. , Gray J.W. , Stern R.
      Oncogene19:870-877(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Regulation of hyaluronidase activity by alternative mRNA splicing."
      Lokeshwar V.B. , Schroeder G.L. , Carey R.I. , Soloway M.S. , Iida N.
      J. Biol. Chem.277:33654-33663(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6);FUNCTION;TISSUE SPECIFICITY
    5. 5.
      Forgacs E. , Sekido Y. , Bader S. , Cundiff S. , Compton L. , Latif F. , Lerman M.I. , Minna J.D.
      Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    7. 7.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 7)
      tissue: Colon.
      tissue: Pancreas.
    9. 9.
      "Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis."
      Chao K.L. , Muthukumar L. , Herzberg O.
      Biochemistry46:6911-6920(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 20-435; IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION AT ASN-99; ASN-216 AND ASN-350;DISULFIDE BONDS
    10. 10.
      "Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX."
      Triggs-Raine B. , Salo T.J. , Zhang H. , Wicklow B.A. , Natowicz M.R.
      Proc. Natl. Acad. Sci. U.S.A.96:6296-6300(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPS9 LYS-268;TISSUE SPECIFICITY
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