IAPP ELISA Kit for Human(Homo sapiens) | EIAab.comIAPP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > IAPP(Gene name) > Human

IAPP (Gene name),

Islet amyloid polypeptide (Protein name ), IAPP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

IAPP;

Protein name:

Islet amyloid polypeptide;

Alternative:

Diabetes-associated peptide(DAP);Amylin;Insulinoma amyloid peptide;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.

Function:

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

Sequence:

50:

89:

HSSNNFGAIL | SSTNVGSNTY | GKRNAVEVLK | REPLNYLPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P10997

Pfam:

PF00214

MIM:

147940

String:

P10997

KEGG:

hsa:3375

UniGene:

Hs.46835

STRING:

9606.ENSP00000240652

Uniprot:

P10997

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ELISA Kit for Human Islet amyloid polypeptide

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E0812h

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96T

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ELISA Kit for Human Islet amyloid polypeptide

Cat.:

E0812r

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96T

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ELISA Kit for Human Islet amyloid polypeptide

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ELISA Kit for Human Islet amyloid polypeptide

Cat.:

E0812m

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ELISA Kit for Human Islet amyloid polypeptide

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E0812b

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ELISA Kit for Human Islet amyloid polypeptide

Cat.:

E0812d

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ELISA Kit for Human Islet amyloid polypeptide

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CLIA Kit for Human Islet amyloid polypeptide

Cat.:

U0812m

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96T

CLIA Kit for Human Islet amyloid polypeptide

MSDS:

Please sign in first.

CLIA Kit for Human Islet amyloid polypeptide

Cat.:

U0812r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human Islet amyloid polypeptide

MSDS:

Please sign in first.

CLIA Kit for Human Islet amyloid polypeptide

Cat.:

U0812h

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

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CLIA Kit for Human Islet amyloid polypeptide

Cat.:

U0812b

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96T

CLIA Kit for Human Islet amyloid polypeptide

Cat.:

U0812d

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96T

Polyclonal Antibody for Human Islet amyloid polypeptide

Cat.:

P0812Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Islet amyloid polypeptide

Cat.:

P0812Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Islet amyloid polypeptide

Cat.:

P0812Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Islet amyloid polypeptide

Protein for Human Islet amyloid polypeptide

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus"

XY Zheng, W Ren, SH Zhang, et al.

From:Acta Diabetol

References

1.

"The complete islet amyloid polypeptide precursor is encoded by two exons."
Mosselman S. , Hoeppener J.W.M. , Lips C.J.M. , Jansz H.S.
FEBS Lett.247:154-158(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];AMIDATION AT TYR-70
2.

"Human islet amyloid polypeptide gene: complete nucleotide sequence, chromosomal localization, and evolutionary history."
Nishi M. , Sanke T. , Seino S. , Eddy R.L. , Fan Y.-S. , Byers M.G. , Shows T.B. , Bell G.I. , Steiner D.F.
Mol. Endocrinol.3:1775-1781(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing."
Sanke T. , Bell G.I. , Sample C. , Rubenstein A.H. , Steiner D.F.
J. Biol. Chem.263:17243-17246(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
4.

"The human islet amyloid polypeptide (IAPP) gene. Organization, chromosomal localization and functional identification of a promoter region."
Christmanson L. , Rorsman F. , Stenman G. , Westermark P. , Betsholtz C.
FEBS Lett.267:160-166(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man."
van Mansfeld A.D.M. , Mosselman S. , Hoeppener J.W.M. , Zandberg J. , van Teeffelen H.A.A.M. , Baas P.D. , Lips C.J.M. , Jansz H.S.
Biochim. Biophys. Acta1087:235-240(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site."
Hoeppener J.W.M. , Oosterwijk C. , Visser-Vernooy H.J. , Lips C.J.M. , Jansz H.S.
Biochem. Biophys. Res. Commun.189:1569-1577(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Cloning and expression of human islet amyloid polypeptide in cultured cells."
Bhattacharya S. , Naveena Lavanya Latha J. , Kumresan R. , Singh S.
Biochem. Biophys. Res. Commun.356:622-628(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;DOMAIN;MASS SPECTROMETRY
tissue: Fetal pancreas.
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"Islet amyloid polypeptide: identification and chromosomal localization of the human gene."
Mosselman S. , Hoeppener J.W.M. , Zandberg J. , van Mansfeld A.D.M. , Geurts van Kessel A.H.M. , Lips C.J.M. , Jansz H.S.
FEBS Lett.239:227-232(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-89
10.

"Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients."
Cooper G.J. , Willis A.C. , Clark A. , Turner R.C. , Sim R.B. , Reid K.B.
Proc. Natl. Acad. Sci. U.S.A.84:8628-8632(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-70;DISULFIDE BOND
11.

"Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."
Betsholtz C. , Christmansson L. , Engstroem U. , Rorsman F. , Svensson V. , Johnson K.H. , Westermark P.
FEBS Lett.251:261-264(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-70;SYNTHESIS OF 53-62
12.

"Isolation and identification of islet amyloid polypeptide in normal human pancreas."
Nakazato M. , Asai J. , Miyazato M. , Matsukura S. , Kangawa K. , Matsuo H.
Regul. Pept.31:179-186(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-70
13.

"A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas."
Westermark P. , Wernstedt C. , Wilander E. , Sletten K.
Biochem. Biophys. Res. Commun.140:827-831(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-52
14.

"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells."
Westermark P. , Wernstedt C. , Wilander E. , Hayden D.W. , O'Brien T.D. , Johnson K.H.
Proc. Natl. Acad. Sci. U.S.A.84:3881-3885(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 34-70
15.

"Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus."
Roberts A.N. , Leighton B. , Todd J.A. , Cockburn D. , Schofield P.N. , Sutton R. , Holt S. , Boyd Y. , Day A.J. , Foot E.A. , Willis A.C. , Reid K.B.M. , Cooper G.J.S.
Proc. Natl. Acad. Sci. U.S.A.86:9662-9666(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-89
16.

"Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin."
Hubbard J.A.M. , Martin S.R. , Chaplin L.C. , Bose C. , Kelly S.M. , Price N.C.
Biochem. J.275:785-788(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF IAPP
17.

"Conformational preferences of the amylin nucleation site in SDS micelles: an NMR study."
Mascioni A. , Porcelli F. , Ilangovan U. , Ramamoorthy A. , Veglia G.
Biopolymers69:29-41(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 53-62 IN DETERGENT MICELLES
18.

"Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism."
Shen Y. , Joachimiak A. , Rosner M.R. , Tang W.-J.
Nature443:870-874(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 34-70 IN COMPLEX WITH IDE;INTERACTION WITH IDE
19.

"Dynamic alpha-helix structure of micelle-bound human amylin."
Patil S.M. , Xu S. , Sheftic S.R. , Alexandrescu A.T.
J. Biol. Chem.284:11982-11991(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 34-70 IN DETERGENT MICELLES;DOMAIN;DISULFIDE BOND
20.

"Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process."
Wiltzius J.J. , Sievers S.A. , Sawaya M.R. , Eisenberg D.
Protein Sci.18:1521-1530(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.86 ANGSTROMS) IN COMPLEX WITH INS;DISULFIDE BOND;MUTAGENESIS OF PHE-48;DOMAIN
21.

"Missense mutation of amylin gene (S20G) in Japanese NIDDM patients."
Sakagashira S. , Sanke T. , Hanabusa T. , Shimomura H. , Ohagi S. , Kumagaye K.Y. , Nakajima K. , Nanjo K.
Diabetes45:1279-1281(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-53
22.

"Role of S20G mutation of amylin gene in insulin secretion, insulin sensitivity, and type II diabetes mellitus in Taiwanese patients."
Chuang L.M. , Lee K.C. , Huang C.N. , Wu H.P. , Tai T.Y. , Lin B.J.
Diabetologia41:1250-1251(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-53

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